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Diagnosis of cardiac surgery-associated acute kidney injury from functional to damage biomarkers

WIM VANDENBERGHE, JORIEN DE LOOR and Eric Hoste UGent (2017) CURRENT OPINION IN ANAESTHESIOLOGY. 30(1). p.66-75
abstract
Purpose of review : Acute kidney injury (AKI) occurs in up to 30% after cardiac surgery and is associated with adverse outcome. Currently, cardiac surgery-associated acute kidney injury (CSA-AKI) is diagnosed by Kidney Disease: Improving Global Outcomes criteria based on creatinine and urine output. To detect and treat AKI earlier, various biomarkers have been evaluated. This review addresses the current position of the two damage biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and [TIMP-2] [IGFBP7] in clinical practice. Recent findings : We present an updated review on the use of blood and urinary NGAL in CSA-AKI. NGAL is a good predictor, and performs better in children than adults. There is a large variation in predictive ability, possibly caused by diversity of AKI definitions used, different time of measurement of NGAL, and lack of specificity of NGAL assays. Similarly, there are conflicting data on the predictive ability of urinary [TIMP-2] [IGFBP7] for CSA-AKI. Recently, both for NGAL and for urinary [TIMP-2] [IGFBP7], a set of actions, based on pretest assessment of risk for CSA-AKI and biomarker test results, was developed. These scores should be evaluated in prospective trials. Summary : NGAL and urinary [TIMP-2] [IGFBP7], in combination with pretest assessment, are promising tools for early detection and treatment in CSA-AKI.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
[TIMP-2] [IGFBP7], acute kidney injury, biomarkers, cardiac surgery, cardiac surgery-associated acute kidney injury, NGAL, GELATINASE-ASSOCIATED LIPOCALIN, CRITICALLY-ILL PATIENTS, CELL-CYCLE ARREST, CARDIOPULMONARY BYPASS-SURGERY, LONG-TERM SURVIVAL, ACUTE RENAL INJURY, SERUM URIC-ACID, URINARY BIOMARKERS, CYSTATIN-C, SUBCLINICAL AKI
journal title
CURRENT OPINION IN ANAESTHESIOLOGY
Curr. Opin. Anaesthesiol.
volume
30
issue
1
pages
66 - 75
Web of Science type
Review
Web of Science id
000392082200011
ISSN
0952-7907
DOI
10.1097/aco.0000000000000419
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8506963
handle
http://hdl.handle.net/1854/LU-8506963
date created
2017-02-02 11:06:14
date last changed
2017-11-13 14:20:34
@article{8506963,
  abstract     = {Purpose of review : Acute kidney injury (AKI) occurs in up to 30\% after cardiac surgery and is associated with adverse outcome. Currently, cardiac surgery-associated acute kidney injury (CSA-AKI) is diagnosed by Kidney Disease: Improving Global Outcomes criteria based on creatinine and urine output. To detect and treat AKI earlier, various biomarkers have been evaluated. This review addresses the current position of the two damage biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and [TIMP-2] [IGFBP7] in clinical practice. 
Recent findings : We present an updated review on the use of blood and urinary NGAL in CSA-AKI. NGAL is a good predictor, and performs better in children than adults. There is a large variation in predictive ability, possibly caused by diversity of AKI definitions used, different time of measurement of NGAL, and lack of specificity of NGAL assays. Similarly, there are conflicting data on the predictive ability of urinary [TIMP-2] [IGFBP7] for CSA-AKI. Recently, both for NGAL and for urinary [TIMP-2] [IGFBP7], a set of actions, based on pretest assessment of risk for CSA-AKI and biomarker test results, was developed. These scores should be evaluated in prospective trials. 
Summary : NGAL and urinary [TIMP-2] [IGFBP7], in combination with pretest assessment, are promising tools for early detection and treatment in CSA-AKI.},
  author       = {VANDENBERGHE, WIM and DE LOOR, JORIEN and Hoste, Eric},
  issn         = {0952-7907},
  journal      = {CURRENT OPINION IN ANAESTHESIOLOGY},
  keyword      = {[TIMP-2] [IGFBP7],acute kidney injury,biomarkers,cardiac surgery,cardiac surgery-associated acute kidney injury,NGAL,GELATINASE-ASSOCIATED LIPOCALIN,CRITICALLY-ILL PATIENTS,CELL-CYCLE ARREST,CARDIOPULMONARY BYPASS-SURGERY,LONG-TERM SURVIVAL,ACUTE RENAL INJURY,SERUM URIC-ACID,URINARY BIOMARKERS,CYSTATIN-C,SUBCLINICAL AKI},
  language     = {eng},
  number       = {1},
  pages        = {66--75},
  title        = {Diagnosis of cardiac surgery-associated acute kidney injury from functional to damage biomarkers},
  url          = {http://dx.doi.org/10.1097/aco.0000000000000419},
  volume       = {30},
  year         = {2017},
}

Chicago
VANDENBERGHE, WIM, JORIEN DE LOOR, and Eric Hoste. 2017. “Diagnosis of Cardiac Surgery-associated Acute Kidney Injury from Functional to Damage Biomarkers.” Current Opinion in Anaesthesiology 30 (1): 66–75.
APA
VANDENBERGHE, WIM, DE LOOR, J., & Hoste, E. (2017). Diagnosis of cardiac surgery-associated acute kidney injury from functional to damage biomarkers. CURRENT OPINION IN ANAESTHESIOLOGY, 30(1), 66–75.
Vancouver
1.
VANDENBERGHE W, DE LOOR J, Hoste E. Diagnosis of cardiac surgery-associated acute kidney injury from functional to damage biomarkers. CURRENT OPINION IN ANAESTHESIOLOGY. 2017;30(1):66–75.
MLA
VANDENBERGHE, WIM, JORIEN DE LOOR, and Eric Hoste. “Diagnosis of Cardiac Surgery-associated Acute Kidney Injury from Functional to Damage Biomarkers.” CURRENT OPINION IN ANAESTHESIOLOGY 30.1 (2017): 66–75. Print.