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Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania

Xiangdong Wang, Nan Zhang UGent, Mingyu Bo, Gabriële Holtappels UGent, Ming Zheng, Hongfei Lou, Hong Wang, Luo Zhang and Claus Bachert UGent (2016) JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 138(5). p.1344-1353
abstract
Background: To date, no study has evaluated the diversity of T-H cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different continents using identical methods. Objective: We sought to assess T-H cytokine profiles in patients with CRS from Europe, Asia, and Australia. Methods: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP; n 5 435) and control subjects (n 5 138) were recruited from centers in Adelaide, Benelux, Berlin, Beijing, Chengdu, and Tochigi. Nasal mucosal concentrations of T(H)2, T(H)17, and T(H)1 cytokines; eosinophilic cationic protein (ECP); myeloperoxidase (MPO); IL-8; and tissue total and Staphylococcus aureus enterotoxin (SE)-specific IgE were measured by using identical tools. Results: Combinations of T(H)1/T(H)2/T(H)17 cytokine profiles in patients with CRSwNP varied considerably between regions. CRSwNP tissues from patients from Benelux, Berlin, Adelaide, and Tochigi were T(H)2 biased, whereas those from Beijing mainly demonstrated T(H)2/T(H)1/T(H)17 mixed patterns, and patients from Chengdu showed an even lower T(H)2 expression. Concentrations of IL-8 and tissue total IgE in patients with CRSwNP were significantly higher than those in control subjects in all regions. More than 50% of patients with CRSwNP in Benelux, Berlin, Adelaide, and Tochigi showed a predominantly eosinophilic endotype compared with less than 30% of patients in Beijing and Chengdu. SE-specific IgE was found in significantly greater numbers in patients with CRSwNP from Benelux, Adelaide, and Tochigi and significantly lower numbers in patients from Beijing and Chengdu. Moreover, the T(H)1/T(H)2/T(H)17 cytokine profiles in patients with CRSsNP showed diversity among the 6 regions. Conclusion: T-H cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
T-H cytokines, IgE, ECP, chronic rhinosinusitis, pheno-type, endotype, Europe, Asia, Australia, CHINESE CHRONIC RHINOSINUSITIS, NASAL POLYPS, SINUS DISEASE, ASTHMA, INFLAMMATION, IGE, ENTEROTOXINS, PHENOTYPES, ENDOTYPES, RESPONSES
journal title
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
J. Allergy Clin. Immunol.
volume
138
issue
5
pages
1344 - 1353
Web of Science type
Article
Web of Science id
000389542700013
JCR category
ALLERGY
JCR impact factor
13.081 (2016)
JCR rank
1/26 (2016)
JCR quartile
1 (2016)
ISSN
0091-6749
DOI
10.1016/j.jaci.2016.05.041
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8506461
handle
http://hdl.handle.net/1854/LU-8506461
date created
2017-01-31 15:29:20
date last changed
2017-02-28 09:03:48
@article{8506461,
  abstract     = {Background: To date, no study has evaluated the diversity of T-H cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different continents using identical methods. 
Objective: We sought to assess T-H cytokine profiles in patients with CRS from Europe, Asia, and Australia. 
Methods: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP; n 5 435) and control subjects (n 5 138) were recruited from centers in Adelaide, Benelux, Berlin, Beijing, Chengdu, and Tochigi. Nasal mucosal concentrations of T(H)2, T(H)17, and T(H)1 cytokines; eosinophilic cationic protein (ECP); myeloperoxidase (MPO); IL-8; and tissue total and Staphylococcus aureus enterotoxin (SE)-specific IgE were measured by using identical tools. 
Results: Combinations of T(H)1/T(H)2/T(H)17 cytokine profiles in patients with CRSwNP varied considerably between regions. CRSwNP tissues from patients from Benelux, Berlin, Adelaide, and Tochigi were T(H)2 biased, whereas those from Beijing mainly demonstrated T(H)2/T(H)1/T(H)17 mixed patterns, and patients from Chengdu showed an even lower T(H)2 expression. Concentrations of IL-8 and tissue total IgE in patients with CRSwNP were significantly higher than those in control subjects in all regions. More than 50\% of patients with CRSwNP in Benelux, Berlin, Adelaide, and Tochigi showed a predominantly eosinophilic endotype compared with less than 30\% of patients in Beijing and Chengdu. SE-specific IgE was found in significantly greater numbers in patients with CRSwNP from Benelux, Adelaide, and Tochigi and significantly lower numbers in patients from Beijing and Chengdu. Moreover, the T(H)1/T(H)2/T(H)17 cytokine profiles in patients with CRSsNP showed diversity among the 6 regions. 
Conclusion: T-H cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.},
  author       = {Wang, Xiangdong and Zhang, Nan and Bo, Mingyu and Holtappels, Gabri{\"e}le and Zheng, Ming and Lou, Hongfei and Wang, Hong and Zhang, Luo and Bachert, Claus},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keyword      = {T-H cytokines,IgE,ECP,chronic rhinosinusitis,pheno-type,endotype,Europe,Asia,Australia,CHINESE CHRONIC RHINOSINUSITIS,NASAL POLYPS,SINUS DISEASE,ASTHMA,INFLAMMATION,IGE,ENTEROTOXINS,PHENOTYPES,ENDOTYPES,RESPONSES},
  language     = {eng},
  number       = {5},
  pages        = {1344--1353},
  title        = {Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a~multicenter study in Europe, Asia, and Oceania},
  url          = {http://dx.doi.org/10.1016/j.jaci.2016.05.041},
  volume       = {138},
  year         = {2016},
}

Chicago
Wang, Xiangdong, Nan Zhang, Mingyu Bo, Gabriële Holtappels, Ming Zheng, Hongfei Lou, Hong Wang, Luo Zhang, and Claus Bachert. 2016. “Diversity of TH Cytokine Profiles in Patients with Chronic Rhinosinusitis : a Multicenter Study in Europe, Asia, and Oceania.” Journal of Allergy and Clinical Immunology 138 (5): 1344–1353.
APA
Wang, Xiangdong, Zhang, N., Bo, M., Holtappels, G., Zheng, M., Lou, H., Wang, H., et al. (2016). Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(5), 1344–1353.
Vancouver
1.
Wang X, Zhang N, Bo M, Holtappels G, Zheng M, Lou H, et al. Diversity of TH cytokine profiles in patients with chronic rhinosinusitis : a multicenter study in Europe, Asia, and Oceania. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;138(5):1344–53.
MLA
Wang, Xiangdong, Nan Zhang, Mingyu Bo, et al. “Diversity of TH Cytokine Profiles in Patients with Chronic Rhinosinusitis : a Multicenter Study in Europe, Asia, and Oceania.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 138.5 (2016): 1344–1353. Print.