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Barrier function of the nasal mucosa in health and type-2 biased airway diseases

Nan Zhang (UGent), Koen Van Crombruggen (UGent), Elien Gevaert (UGent) and Claus Bachert (UGent)
(2016) ALLERGY. 71(3). p.295-307
Author
Organization
Abstract
The mucosal lining of the upper airways represents the outer surface of the body to the ambient air and its contents and is prepared for it as the first line of defense. Apart from the well-described physical barrier and the mucociliary clearance, a variety of systems, including the airway microbiome, antimicrobial proteins, damage-associated molecular patterns, innate lymphoid cells, epithelial-derived cytokines and chemokines, and finally the adaptive immune system, as well as eosinophils as newly appreciated defense cells form different levels of protection against and response to any possible intruder. Of interest especially for allergic airway disease, mucosal germs might not just elicit a classical Th1/Th17-biased inflammatory response, but may directly induce a type-2 mucosal inflammation. Innovative therapeutic interventions may be possible at different levels also; however, whether modulations of the innate or adaptive immune responses will finally be more successful, and how the correction of the adaptive immune response might impact on the innate side, will be determined in the near future.
Keywords
allergic rhinitis, chronic rhinosinusitis with nasal polyps, eosinophil extracellular traps, immune response, nasal epithelial barrier, INNATE LYMPHOID-CELLS, CHRONIC RHINOSINUSITIS PATIENTS, DEFECTIVE EPITHELIAL BARRIER, INDUCED ASTHMATIC RESPONSES, UPPER RESPIRATORY-INFECTION, PARANASAL SINUS MUCOSA, STAPHYLOCOCCUS-AUREUS, ALLERGIC RHINITIS, IMMUNE-RESPONSES, TH2 CYTOKINES

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Citation

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Chicago
Zhang, Nan, Koen Van Crombruggen, Elien Gevaert, and Claus Bachert. 2016. “Barrier Function of the Nasal Mucosa in Health and Type-2 Biased Airway Diseases.” Allergy 71 (3): 295–307.
APA
Zhang, Nan, Van Crombruggen, K., Gevaert, E., & Bachert, C. (2016). Barrier function of the nasal mucosa in health and type-2 biased airway diseases. ALLERGY, 71(3), 295–307.
Vancouver
1.
Zhang N, Van Crombruggen K, Gevaert E, Bachert C. Barrier function of the nasal mucosa in health and type-2 biased airway diseases. ALLERGY. 2016;71(3):295–307.
MLA
Zhang, Nan, Koen Van Crombruggen, Elien Gevaert, et al. “Barrier Function of the Nasal Mucosa in Health and Type-2 Biased Airway Diseases.” ALLERGY 71.3 (2016): 295–307. Print.
@article{8506386,
  abstract     = {The mucosal lining of the upper airways represents the outer surface of the body to the ambient air and its contents and is prepared for it as the first line of defense. Apart from the well-described physical barrier and the mucociliary clearance, a variety of systems, including the airway microbiome, antimicrobial proteins, damage-associated molecular patterns, innate lymphoid cells, epithelial-derived cytokines and chemokines, and finally the adaptive immune system, as well as eosinophils as newly appreciated defense cells form different levels of protection against and response to any possible intruder. Of interest especially for allergic airway disease, mucosal germs might not just elicit a classical Th1/Th17-biased inflammatory response, but may directly induce a type-2 mucosal inflammation. Innovative therapeutic interventions may be possible at different levels also; however, whether modulations of the innate or adaptive immune responses will finally be more successful, and how the correction of the adaptive immune response might impact on the innate side, will be determined in the near future.},
  author       = {Zhang, Nan and Van Crombruggen, Koen and Gevaert, Elien and Bachert, Claus},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {allergic rhinitis,chronic rhinosinusitis with nasal polyps,eosinophil extracellular traps,immune response,nasal epithelial barrier,INNATE LYMPHOID-CELLS,CHRONIC RHINOSINUSITIS PATIENTS,DEFECTIVE EPITHELIAL BARRIER,INDUCED ASTHMATIC RESPONSES,UPPER RESPIRATORY-INFECTION,PARANASAL SINUS MUCOSA,STAPHYLOCOCCUS-AUREUS,ALLERGIC RHINITIS,IMMUNE-RESPONSES,TH2 CYTOKINES},
  language     = {eng},
  number       = {3},
  pages        = {295--307},
  title        = {Barrier function of the nasal mucosa in health and type-2 biased airway diseases},
  url          = {http://dx.doi.org/10.1111/all.12809},
  volume       = {71},
  year         = {2016},
}

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