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Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans : joint RENEB and EURADOS inter-laboratory comparisons

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Abstract
Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.
Keywords
Biodosimetry, physical retrospective dosimetry, radiation accidents, RENEB, PERIPHERAL-BLOOD LYMPHOCYTES, DICENTRIC CHROMOSOMES, IONIZING-RADIATION, GENE-EXPRESSION, IN-VITRO, TRIAGE, SPECTROSCOPY, TELOMERE, NETWORK, TOOL

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Chicago
Ainsbury, Elizabeth, Christophe Badie, Stephen Barnard, Grainne Manning, Jayne Moquet, Michael Abend, Ana Catarina Antunes, et al. 2017. “Integration of New Biological and Physical Retrospective Dosimetry Methods into EU Emergency Response Plans : Joint RENEB and EURADOS Inter-laboratory Comparisons.” International Journal of Radiation Biology 93 (1): 99–109.
APA
Ainsbury, Elizabeth, Badie, C., Barnard, S., Manning, G., Moquet, J., Abend, M., Antunes, A. C., et al. (2017). Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans : joint RENEB and EURADOS inter-laboratory comparisons. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 93(1), 99–109.
Vancouver
1.
Ainsbury E, Badie C, Barnard S, Manning G, Moquet J, Abend M, et al. Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans : joint RENEB and EURADOS inter-laboratory comparisons. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2017;93(1):99–109.
MLA
Ainsbury, Elizabeth, Christophe Badie, Stephen Barnard, et al. “Integration of New Biological and Physical Retrospective Dosimetry Methods into EU Emergency Response Plans : Joint RENEB and EURADOS Inter-laboratory Comparisons.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 93.1 (2017): 99–109. Print.
@article{8504061,
  abstract     = {Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. 
Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation induced thermoluminescent signals in glass screens taken from mobile phones. 
Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. 
Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.},
  author       = {Ainsbury, Elizabeth and Badie, Christophe and Barnard, Stephen and Manning, Grainne and Moquet, Jayne and Abend, Michael and Antunes, Ana Catarina and Barrios, Lleonard and Bassinet, Celine and Beinke, Christina and Bortolin, Emanuela and Bossin, Lily and Bricknell, Clare and Brzoska, Kamil and Buraczewska, Iwona and Casta{\~n}o, Carlos Huertas and \v{C}emusov{\'a}, Zina and Christiansson, Maria and Cordero, Santiago Mateos and Cosler, Guillaume and Della Monaca, Sara and Desangles, Fran\c{c}ois and Discher, Michael and Dominguez, Inmaculada and Doucha-Senf, Sven and Eakins, Jon and Fattibene, Paola and Filippi, Silvia and Frenzel, Monika and Georgieva, Dimka and Gregoire, Eric and Guogyte, Kamile and Hadjidekova, Valeria and Hadjiiska, Ljubomira and Hristova, Rositsa and Karakosta, Maria and Kis, Enik\unmatched{0151} and Kriehuber, Ralf and Lee, Jungil and Lloyd, David and Lumniczky, Katalin and Lyng, Fiona and Macaeva, Ellina and Majewski, Matthaeus and Vanda Martins, S and McKeever, Stephen WS and Meade, Aidan and Medipally, Dinesh and Meschini, Roberta and M{\textquoteright}kacher, Radhia and Gil, Oct{\'a}via Monteiro and Montero, Alegria and Moreno, Mercedes and Noditi, Mihaela and Oestreicher, Ursula and Oskamp, Dominik and Palitti, Fabrizio and Palma, Valentina and Pantelias, Gabriel and Pateux, Jerome and Patrono, Clarice and Pepe, Gaetano and Port, Matthias and Prieto, Mar{\'i}a Jes{\'u}s and Quattrini, Maria Cristina and Quintens, Roel and Ricoul, Michelle and Roy, Laurence and Sabatier, Laure and Sebasti{\`a}, Natividad and Sholom, Sergey and Sommer, Sylwester and Staynova, Albena and Strunz, Sonja and Terzoudi, Georgia and Testa, Antonella and Trompier, Fran\c{c}ois and Valente, Marco and Van Hoey, Olivier and Veronese, Ivan and Wojcik, Andrzej and Woda, Clemens},
  issn         = {0955-3002},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {99--109},
  title        = {Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans : joint RENEB and EURADOS inter-laboratory comparisons},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1206233},
  volume       = {93},
  year         = {2017},
}

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