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Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts

Joke Tommelein, Félix Gremonprez UGent, Laurine Verset, Elly De Vlieghere UGent, Glenn Wagemans UGent, Christian Gespach, Tom Boterberg UGent, Pieter Demetter, Wim Ceelen UGent, Marc Bracke UGent, et al. (2016) ONCOTARGET. 7(46). p.75603-75615
abstract
In patients with rectal prolapse is the prevalence of colorectal cancer increased, suggesting that a colorectal tumor may induce rectal prolapse. Establishment of tumor xenografts in immunodeficient mice after orthotopic inoculations of human colorectal cancer cells into the caecal wall is a widely used approach for the study of human colorectal cancer progression and preclinical evaluation of therapeutics. Remarkably, 70% of young mice carrying a COLO320DM caecal tumor showed symptoms of intussusception of the large bowel associated with intestinal lumen obstruction and rectal prolapse. The quantity of the COLO320DM bioluminescent signal of the first three weeks post-inoculation predicts prolapse in young mice. Rectal prolapse was not observed in adult mice carrying a COLO320DM caecal tumor or young mice carrying a HT29 caecal tumor. In contrast to HT29 tumors, which showed local invasion and metastasis, COLO320DM tumors demonstrated a non-invasive tumor with pushing borders without presence of metastasis. In conclusion, rectal prolapse can be linked to a non-invasive, space-occupying COLO320DM tumor in the gastrointestinal tract of young immunodeficient mice. These data reveal a model that can clarify the association of patients showing rectal prolapse with colorectal cancer.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
rectal prolapse, COLO320DM, colorectal cancer, orthotopic, mouse model, HUMAN-COLON-CARCINOMA, GROWTH-FACTOR RECEPTOR, NUDE-MICE, ENDOTHELIAL-CELLS, ULCER SYNDROME, IN-VIVO, METASTASIS, INTUSSUSCEPTION, INHIBITION, THERAPY
journal title
ONCOTARGET
Oncotarget
volume
7
issue
46
pages
75603 - 75615
Web of Science type
Article
Web of Science id
000389632800092
JCR category
ONCOLOGY
JCR impact factor
5.168 (2016)
JCR rank
44/217 (2016)
JCR quartile
1 (2016)
ISSN
1949-2553
DOI
10.18632/oncotarget.12312
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8502786
handle
http://hdl.handle.net/1854/LU-8502786
date created
2017-01-18 13:40:55
date last changed
2017-04-13 09:16:07
@article{8502786,
  abstract     = {In patients with rectal prolapse is the prevalence of colorectal cancer increased, suggesting that a colorectal tumor may induce rectal prolapse. Establishment of tumor xenografts in immunodeficient mice after orthotopic inoculations of human colorectal cancer cells into the caecal wall is a widely used approach for the study of human colorectal cancer progression and preclinical evaluation of therapeutics. Remarkably, 70\% of young mice carrying a COLO320DM caecal tumor showed symptoms of intussusception of the large bowel associated with intestinal lumen obstruction and rectal prolapse. The quantity of the COLO320DM bioluminescent signal of the first three weeks post-inoculation predicts prolapse in young mice. Rectal prolapse was not observed in adult mice carrying a COLO320DM caecal tumor or young mice carrying a HT29 caecal tumor. In contrast to HT29 tumors, which showed local invasion and metastasis, COLO320DM tumors demonstrated a non-invasive tumor with pushing borders without presence of metastasis. In conclusion, rectal prolapse can be linked to a non-invasive, space-occupying COLO320DM tumor in the gastrointestinal tract of young immunodeficient mice. These data reveal a model that can clarify the association of patients showing rectal prolapse with colorectal cancer.},
  author       = {Tommelein, Joke and Gremonprez, F{\'e}lix and Verset, Laurine and De Vlieghere, Elly and Wagemans, Glenn and Gespach, Christian and Boterberg, Tom and Demetter, Pieter and Ceelen, Wim and Bracke, Marc and De Wever, Olivier},
  issn         = {1949-2553},
  journal      = {ONCOTARGET},
  keyword      = {rectal prolapse,COLO320DM,colorectal cancer,orthotopic,mouse model,HUMAN-COLON-CARCINOMA,GROWTH-FACTOR RECEPTOR,NUDE-MICE,ENDOTHELIAL-CELLS,ULCER SYNDROME,IN-VIVO,METASTASIS,INTUSSUSCEPTION,INHIBITION,THERAPY},
  language     = {eng},
  number       = {46},
  pages        = {75603--75615},
  title        = {Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts},
  url          = {http://dx.doi.org/10.18632/oncotarget.12312},
  volume       = {7},
  year         = {2016},
}

Chicago
Tommelein, Joke, Félix Gremonprez, Laurine Verset, Elly De Vlieghere, Glenn Wagemans, Christian Gespach, Tom Boterberg, et al. 2016. “Age and Cellular Context Influence Rectal Prolapse Formation in Mice with Caecal Wall Colorectal Cancer Xenografts.” Oncotarget 7 (46): 75603–75615.
APA
Tommelein, J., Gremonprez, F., Verset, L., De Vlieghere, E., Wagemans, G., Gespach, C., Boterberg, T., et al. (2016). Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts. ONCOTARGET, 7(46), 75603–75615.
Vancouver
1.
Tommelein J, Gremonprez F, Verset L, De Vlieghere E, Wagemans G, Gespach C, et al. Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts. ONCOTARGET. 2016;7(46):75603–15.
MLA
Tommelein, Joke, Félix Gremonprez, Laurine Verset, et al. “Age and Cellular Context Influence Rectal Prolapse Formation in Mice with Caecal Wall Colorectal Cancer Xenografts.” ONCOTARGET 7.46 (2016): 75603–75615. Print.