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  2. Wars2 is a determinant of angiogenesis

Wars2 is a determinant of angiogenesis

Mao Wang, Patrick Sips (UGent) , Ester Khin, Maxime Rotival, Ximing Sun, Rizwan Ahmed, Anissa Anindya Widjaja, Sebastian Schafer, Permeen Yusoff, Pervinder Kaur Choksi, et al.
(2016) NATURE COMMUNICATIONS. 7.
Author
Organization
Abstract
Coronary flow (CF) measured ex vivo is largely determined by capillary density that reflects angiogenic vessel formation in the heart in vivo. Here we exploit this relationship and show that CF in the rat is influenced by a locus on rat chromosome 2 that is also associated with cardiac capillary density. Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F protein variant within the ATP-binding motif, is prioritized as the candidate at the locus by integrating genomic data sets. WARS2(L53F) has low enzyme activity and inhibition of WARS2 in endothelial cells reduces angiogenesis. In the zebrafish, inhibition of wars2 results in trunk vessel deficiencies, disordered endocardial-myocardial contact and impaired heart function. Inhibition of Wars2 in the rat causes cardiac angiogenesis defects and diminished cardiac capillary density. Our data demonstrate a pro-angiogenic function for Wars2 both within and outside the heart that may have translational relevance given the association of WARS2 with common human diseases.
Keywords
TRANSFER-RNA-SYNTHETASE, SPONTANEOUSLY HYPERTENSIVE-RAT, CORONARY VASCULATURE, CARDIAC-HYPERTROPHY, HEART-FAILURE, ZEBRAFISH, BLOOD, DEFICIENCY, REVEALS, GROWTH

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Citation

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MLA
Wang, Mao, et al. “Wars2 Is a Determinant of Angiogenesis.” NATURE COMMUNICATIONS, vol. 7, 2016, doi:10.1038/ncomms12061.
APA
Wang, M., Sips, P., Khin, E., Rotival, M., Sun, X., Ahmed, R., … Cook, S. A. (2016). Wars2 is a determinant of angiogenesis. NATURE COMMUNICATIONS, 7. https://doi.org/10.1038/ncomms12061
Chicago author-date
Wang, Mao, Patrick Sips, Ester Khin, Maxime Rotival, Ximing Sun, Rizwan Ahmed, Anissa Anindya Widjaja, et al. 2016. “Wars2 Is a Determinant of Angiogenesis.” NATURE COMMUNICATIONS 7. https://doi.org/10.1038/ncomms12061.
Chicago author-date (all authors)
Wang, Mao, Patrick Sips, Ester Khin, Maxime Rotival, Ximing Sun, Rizwan Ahmed, Anissa Anindya Widjaja, Sebastian Schafer, Permeen Yusoff, Pervinder Kaur Choksi, Nicole Shi Jie Ko, Manvendra K Singh, David Epstein, Yuguang Guan, Josef Houštěk, Tomas Mracek, Hana Nuskova, Brittney Mikell, Jessie Tan, Francesco Pesce, Frantisek Kolar, Leonardo Bottolo, Massimiliano Mancini, Norbert Hubner, Michal Pravenec, Enrico Petretto, Calum MacRae, and Stuart A Cook. 2016. “Wars2 Is a Determinant of Angiogenesis.” NATURE COMMUNICATIONS 7. doi:10.1038/ncomms12061.
Vancouver
1.
Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, et al. Wars2 is a determinant of angiogenesis. NATURE COMMUNICATIONS. 2016;7.
IEEE
[1]
M. Wang et al., “Wars2 is a determinant of angiogenesis,” NATURE COMMUNICATIONS, vol. 7, 2016.
@article{8502692,
  abstract     = {{Coronary flow (CF) measured ex vivo is largely determined by capillary density that reflects angiogenic vessel formation in the heart in vivo. Here we exploit this relationship and show that CF in the rat is influenced by a locus on rat chromosome 2 that is also associated with cardiac capillary density. Mitochondrial tryptophanyl-tRNA synthetase (Wars2), encoding an L53F protein variant within the ATP-binding motif, is prioritized as the candidate at the locus by integrating genomic data sets. WARS2(L53F) has low enzyme activity and inhibition of WARS2 in endothelial cells reduces angiogenesis. In the zebrafish, inhibition of wars2 results in trunk vessel deficiencies, disordered endocardial-myocardial contact and impaired heart function. Inhibition of Wars2 in the rat causes cardiac angiogenesis defects and diminished cardiac capillary density. Our data demonstrate a pro-angiogenic function for Wars2 both within and outside the heart that may have translational relevance given the association of WARS2 with common human diseases.}},
  articleno    = {{12061}},
  author       = {{Wang, Mao and Sips, Patrick and Khin, Ester and Rotival, Maxime and Sun, Ximing and Ahmed, Rizwan and Widjaja, Anissa Anindya and Schafer, Sebastian and Yusoff, Permeen and Choksi, Pervinder Kaur and Ko, Nicole Shi Jie and Singh, Manvendra K and Epstein, David and Guan, Yuguang and Houštěk, Josef and Mracek, Tomas and Nuskova, Hana and Mikell, Brittney and Tan, Jessie and Pesce, Francesco and Kolar, Frantisek and Bottolo, Leonardo and Mancini, Massimiliano and Hubner, Norbert and Pravenec, Michal and Petretto, Enrico and MacRae, Calum and Cook, Stuart A}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{TRANSFER-RNA-SYNTHETASE,SPONTANEOUSLY HYPERTENSIVE-RAT,CORONARY VASCULATURE,CARDIAC-HYPERTROPHY,HEART-FAILURE,ZEBRAFISH,BLOOD,DEFICIENCY,REVEALS,GROWTH}},
  language     = {{eng}},
  pages        = {{12}},
  title        = {{Wars2 is a determinant of angiogenesis}},
  url          = {{http://doi.org/10.1038/ncomms12061}},
  volume       = {{7}},
  year         = {{2016}},
}
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