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Respiratory hypersensitivity reactions to NSAIDs in Europe : the global allergy and asthma network (GA2LEN) survey

(2016) ALLERGY. 71(11). p.1603-1611
Author
Abstract
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders. Methods: The GA(2)LEN survey was conducted in 22 centers in 15 European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled. Questionnaires including questions about age, gender, presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking status, and history of NSAID-induced hypersensitivity reactions were sent to participants by mail. Totally, 62 737 participants completed the questionnaires. Results: The mean prevalence of NSAID-induced dyspnea was 1.9% and was highest in the three Polish centers [Katowice (4.9%), Krakow (4.8%), and Lodz (4.4%)] and lowest in Skopje, (0.9%), Amsterdam (1.1%), and Umea (1.2%). In multivariate analysis, the prevalence of respiratory reactions to NSAIDs was higher in participants with chronic rhinosinusitis symptoms (Odds Ratio 2.12; 95%CI 1.78-2.74), asthma symptoms in last 12 months (2.7; 2.18-3.35), hospitalization due to asthma (1.53; 1.22-1.99), and adults vs children (1.53; 1.24-1.89), but was not associated with allergic rhinitis. Conclusion: Our study documented significant variation between European countries in the prevalence of NSAID-induced respiratory hypersensitivity reactions, and association with chronic airway diseases, but also with environmental factors.
Keywords
drug allergy, epidemiology, GA2LEN, NSAIDs hypersensitivity, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ASPIRIN-INTOLERANT ASTHMA, QUESTIONNAIRE SURVEY, PROVOCATION TESTS, NASAL POLYPOSIS, NATURAL-HISTORY, PREVALENCE, POPULATION, DISEASE, CLASSIFICATION

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MLA
Makowska, JS, P Burney, D Jarvis, et al. “Respiratory Hypersensitivity Reactions to NSAIDs in Europe : the Global Allergy and Asthma Network (GA2LEN) Survey.” ALLERGY 71.11 (2016): 1603–1611. Print.
APA
Makowska, J., Burney, P., Jarvis, D., Keil, T., Tomassen, P., Bislimovska, J., Brozek, G., et al. (2016). Respiratory hypersensitivity reactions to NSAIDs in Europe : the global allergy and asthma network (GA2LEN) survey. ALLERGY, 71(11), 1603–1611.
Chicago author-date
Makowska, JS, P Burney, D Jarvis, T Keil, Peter Tomassen, J Bislimovska, G Brozek, et al. 2016. “Respiratory Hypersensitivity Reactions to NSAIDs in Europe : the Global Allergy and Asthma Network (GA2LEN) Survey.” Allergy 71 (11): 1603–1611.
Chicago author-date (all authors)
Makowska, JS, P Burney, D Jarvis, T Keil, Peter Tomassen, J Bislimovska, G Brozek, Claus Bachert, J Baelum, C Bindslev-Jensen, J Bousquet, PJ Bousquet, C Kai-Håkon, SE Dahlen, B Dahlen, WJ Fokkens, B Forsberg, M Gjomarkaj, P Howarth, E Salagean, C Janson, L Kasper, U Kraemer, C Louiro, B Lundback, J Minov, E Nizankowska-Mogilnicka, N Papadopoulos, AG Sakellariou, A Todo-Bom, E Toskala, JE Zejda, T Zuberbier, and ML Kowalski. 2016. “Respiratory Hypersensitivity Reactions to NSAIDs in Europe : the Global Allergy and Asthma Network (GA2LEN) Survey.” Allergy 71 (11): 1603–1611.
Vancouver
1.
Makowska J, Burney P, Jarvis D, Keil T, Tomassen P, Bislimovska J, et al. Respiratory hypersensitivity reactions to NSAIDs in Europe : the global allergy and asthma network (GA2LEN) survey. ALLERGY. 2016;71(11):1603–11.
IEEE
[1]
J. Makowska et al., “Respiratory hypersensitivity reactions to NSAIDs in Europe : the global allergy and asthma network (GA2LEN) survey,” ALLERGY, vol. 71, no. 11, pp. 1603–1611, 2016.
@article{8502451,
  abstract     = {Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders. 
Methods: The GA(2)LEN survey was conducted in 22 centers in 15 European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled. Questionnaires including questions about age, gender, presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking status, and history of NSAID-induced hypersensitivity reactions were sent to participants by mail. Totally, 62 737 participants completed the questionnaires. 
Results: The mean prevalence of NSAID-induced dyspnea was 1.9% and was highest in the three Polish centers [Katowice (4.9%), Krakow (4.8%), and Lodz (4.4%)] and lowest in Skopje, (0.9%), Amsterdam (1.1%), and Umea (1.2%). In multivariate analysis, the prevalence of respiratory reactions to NSAIDs was higher in participants with chronic rhinosinusitis symptoms (Odds Ratio 2.12; 95%CI 1.78-2.74), asthma symptoms in last 12 months (2.7; 2.18-3.35), hospitalization due to asthma (1.53; 1.22-1.99), and adults vs children (1.53; 1.24-1.89), but was not associated with allergic rhinitis. 
Conclusion: Our study documented significant variation between European countries in the prevalence of NSAID-induced respiratory hypersensitivity reactions, and association with chronic airway diseases, but also with environmental factors.},
  author       = {Makowska, JS and Burney, P and Jarvis, D and Keil, T and Tomassen, Peter and Bislimovska, J and Brozek, G and Bachert, Claus and Baelum, J and Bindslev-Jensen, C and Bousquet, J and Bousquet, PJ and Kai-Håkon, C and Dahlen, SE and Dahlen, B and Fokkens, WJ and Forsberg, B and Gjomarkaj, M and Howarth, P and Salagean, E and Janson, C and Kasper, L and Kraemer, U and Louiro, C and Lundback, B and Minov, J and Nizankowska-Mogilnicka, E and Papadopoulos, N and Sakellariou, AG and Todo-Bom, A and Toskala, E and Zejda, JE and Zuberbier, T and Kowalski, ML},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {drug allergy,epidemiology,GA2LEN,NSAIDs hypersensitivity,NONSTEROIDAL ANTIINFLAMMATORY DRUGS,ASPIRIN-INTOLERANT ASTHMA,QUESTIONNAIRE SURVEY,PROVOCATION TESTS,NASAL POLYPOSIS,NATURAL-HISTORY,PREVALENCE,POPULATION,DISEASE,CLASSIFICATION},
  language     = {eng},
  number       = {11},
  pages        = {1603--1611},
  title        = {Respiratory hypersensitivity reactions to NSAIDs in Europe : the global allergy and asthma network (GA2LEN) survey},
  url          = {http://dx.doi.org/10.1111/all.12941},
  volume       = {71},
  year         = {2016},
}

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