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Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles

(2017) SYNLETT. 28(2). p.207-213
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Abstract
A variety of different N-[2-chloro-4-(chloromethyl)pent-4-enylidene]amines and N-(2,6-dichlorohex-4-enylidene)amines was prepared for the first time, and their reactivity as eligible building blocks for the synthesis of biologically relevant nitrogen-containing heterocyclic compounds was studied. In this way, a convenient entry into functionalized 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles, and tetrahydroindoles was developed, pointing to the broad synthetic flexibility of these dichlorinated imine substrates.
Keywords
-dichloroketimines, 1-azabicyclo[3_1_ 0]hexanes, piperidines, pyridines, pyrroles, tetrahydroindoles, HALOGENATED IMINO COMPOUNDS, DIELS-ALDER REACTIONS, STEREOSELECTIVE-SYNTHESIS, ALPHA-CYANOAZIRIDINES, BETA-LACTAMS, KETIMINES, CHLOROIMINES, AZIRIDINES, CHEMISTRY, REARRANGEMENT

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Citation

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Chicago
Piens, Nicola, Wim Aelterman, Matthias D’hooghe, and Norbert De Kimpe. 2017. “Use of Α,ω-dichloroketimine Building Blocks for the Construction of 1-azabicyclo[3.1.0]hexanes, Piperidines, Pyridines, Pyrroles and Tetrahydroindoles.” Synlett 28 (2): 207–213.
APA
Piens, N., Aelterman, W., D’hooghe, M., & De Kimpe, N. (2017). Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles. SYNLETT, 28(2), 207–213.
Vancouver
1.
Piens N, Aelterman W, D’hooghe M, De Kimpe N. Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles. SYNLETT. 2017;28(2):207–13.
MLA
Piens, Nicola et al. “Use of Α,ω-dichloroketimine Building Blocks for the Construction of 1-azabicyclo[3.1.0]hexanes, Piperidines, Pyridines, Pyrroles and Tetrahydroindoles.” SYNLETT 28.2 (2017): 207–213. Print.
@article{8502089,
  abstract     = {A variety of different N-[2-chloro-4-(chloromethyl)pent-4-enylidene]amines and N-(2,6-dichlorohex-4-enylidene)amines was prepared for the first time, and their reactivity as eligible building blocks for the synthesis of biologically relevant nitrogen-containing heterocyclic compounds was studied. In this way, a convenient entry into functionalized 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles, and tetrahydroindoles was developed, pointing to the broad synthetic flexibility of these dichlorinated imine substrates.},
  author       = {Piens, Nicola and Aelterman, Wim and D'hooghe, Matthias and De Kimpe, Norbert},
  issn         = {0936-5214},
  journal      = {SYNLETT},
  keywords     = {-dichloroketimines,1-azabicyclo[3_1_ 0]hexanes,piperidines,pyridines,pyrroles,tetrahydroindoles,HALOGENATED IMINO COMPOUNDS,DIELS-ALDER REACTIONS,STEREOSELECTIVE-SYNTHESIS,ALPHA-CYANOAZIRIDINES,BETA-LACTAMS,KETIMINES,CHLOROIMINES,AZIRIDINES,CHEMISTRY,REARRANGEMENT},
  language     = {eng},
  number       = {2},
  pages        = {207--213},
  title        = {Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles},
  url          = {http://dx.doi.org/10.1055/s-0036-1588882},
  volume       = {28},
  year         = {2017},
}

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