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Are antihistamines effective in children? : a review of the evidence

Pauline De Bruyne UGent, Thierry Christiaens UGent, Koen Boussery UGent, Els Mehuys UGent and Myriam Van Winckel UGent (2017) ARCHIVES OF DISEASE IN CHILDHOOD. 102(1). p.56-60
abstract
BACKGROUND AND AIMS: During the last decades, much attention has been paid to off-label and unlicensed prescriptions in paediatrics. However, on-label prescribing can also cause health issues. In this paper, the case of first-generation H1-antihistamines is investigated, notably the range of indications for which products are licensed in different European countries and the evidence base (or lack thereof) for each indication, as well as reported adverse drug reactions. METHODS: Review of the Summary of Product Characteristics of first-generation H1-antihistamines with a focus on paediatric use. This is plotted against the evidence available in the literature. RESULTS: This investigation shows a large variability in labelled indications and licensing ages when compared in five different European countries. Moreover, most of the indications are not based on clinical trials evaluating efficacy and safety of these drugs in children. CONCLUSIONS: Many of the licensed indications of first-generation antihistamines do not appear to be evidence based.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ntihistamines, Children, Over-the-counter medication, Paediatrics
journal title
ARCHIVES OF DISEASE IN CHILDHOOD
Arch. Dis. Child.
volume
102
issue
1
pages
56 - 60
ISSN
0003-9888
DOI
10.1136/archdischild-2015-310416
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8501451
handle
http://hdl.handle.net/1854/LU-8501451
date created
2017-01-11 12:07:17
date last changed
2017-02-06 15:01:03
@article{8501451,
  abstract     = {BACKGROUND AND AIMS: During the last decades, much attention has been paid to off-label and unlicensed prescriptions in paediatrics. However, on-label prescribing can also cause health issues. In this paper, the case of first-generation H1-antihistamines is investigated, notably the range of indications for which products are licensed in different European countries and the evidence base (or lack thereof) for each indication, as well as reported adverse drug reactions.
METHODS: Review of the Summary of Product Characteristics of first-generation H1-antihistamines with a focus on paediatric use. This is plotted against the evidence available in the literature.
RESULTS: This investigation shows a large variability in labelled indications and licensing ages when compared in five different European countries. Moreover, most of the indications are not based on clinical trials evaluating efficacy and safety of these drugs in children.
CONCLUSIONS: Many of the licensed indications of first-generation antihistamines do not appear to be evidence based.},
  author       = {De Bruyne, Pauline and Christiaens, Thierry and Boussery, Koen and Mehuys, Els and Van Winckel, Myriam},
  issn         = { 0003-9888},
  journal      = {ARCHIVES OF DISEASE IN CHILDHOOD},
  keyword      = {ntihistamines,Children,Over-the-counter medication,Paediatrics},
  language     = {eng},
  number       = {1},
  pages        = {56--60},
  title        = {Are antihistamines effective in children? : a review of the evidence},
  url          = {http://dx.doi.org/10.1136/archdischild-2015-310416},
  volume       = {102},
  year         = {2017},
}

Chicago
De Bruyne, Pauline, Thierry Christiaens, Koen Boussery, Els Mehuys, and Myriam Van Winckel. 2017. “Are Antihistamines Effective in Children? : a Review of the Evidence.” Archives of Disease in Childhood 102 (1): 56–60.
APA
De Bruyne, P., Christiaens, T., Boussery, K., Mehuys, E., & Van Winckel, M. (2017). Are antihistamines effective in children? : a review of the evidence. ARCHIVES OF DISEASE IN CHILDHOOD, 102(1), 56–60.
Vancouver
1.
De Bruyne P, Christiaens T, Boussery K, Mehuys E, Van Winckel M. Are antihistamines effective in children? : a review of the evidence. ARCHIVES OF DISEASE IN CHILDHOOD. 2017;102(1):56–60.
MLA
De Bruyne, Pauline, Thierry Christiaens, Koen Boussery, et al. “Are Antihistamines Effective in Children? : a Review of the Evidence.” ARCHIVES OF DISEASE IN CHILDHOOD 102.1 (2017): 56–60. Print.