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Prevalence of comorbidities and evaluation of their screening in spondyloarthritis : results of the international cross-sectional ASAS-COMOSPA study

(2015) ANNALS OF THE RHEUMATIC DISEASES. 75(6). p.1016-1023
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Abstract
Background: Increased risk of some comorbidities has been reported in spondyloarthritis (SpA). Recommendations for detection/management of some of these comorbidities have been proposed, and it is known that a gap exists between these and their implementation in practice. Objective: To evaluate (1) the prevalence of comorbidities and risk factors in different countries worldwide, (2) the gap between available recommendations and daily practice for management of these comorbidities and (3) the prevalence of previously unknown risk factors detected as a result of the present initiative. Methods: Cross-sectional international study with 22 participating countries (from four continents), including 3984 patients with SpA according to the rheumatologist. Statistical analysis: The prevalence of comorbidities (cardiovascular, infection, cancer, osteoporosis and gastrointestinal) and risk factors; percentage of patients optimally monitored for comorbidities according to available recommendations and percentage of patients for whom a risk factor was detected due to this study. Results: The most frequent comorbidities were osteoporosis (13%) and gastroduodenal ulcer (11%). The most frequent risk factors were hypertension (34%), smoking (29%) and hypercholesterolaemia (27%). Substantial intercountry variability was observed for screening of comorbidities (eg, for LDL cholesterol measurement: from 8% (Taiwan) to 98% (Germany)). Systematic evaluation (eg, blood pressure (BP), cholesterol) during this study unveiled previously unknown risk factors (eg, elevated BP (14%)), emphasising the suboptimal monitoring of comorbidities. Conclusions: A high prevalence of comorbidities in SpA has been shown. Rigorous application of systematic evaluation of comorbidities may permit earlier detection, which may ultimately result in an improved outcome of patients with SpA.
Keywords
OF-THE-LITERATURE, POPULATION-BASED COHORT, BONE-MINERAL DENSITY, ANKYLOSING-SPONDYLITIS, RHEUMATOID-ARTHRITIS, BODY-COMPOSITION, CANCER INCIDENCE, HEART-DISEASE, RISK, RECOMMENDATIONS

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Chicago
Moltó, Anna, Adrien Etcheto, Désirée van der Heijde, Robert Landewé, Filip Van den Bosch, Wilson Bautista Molano, Ruben Burgos-Vargas, et al. 2015. “Prevalence of Comorbidities and Evaluation of Their Screening in Spondyloarthritis : Results of the International Cross-sectional ASAS-COMOSPA Study.” Annals of the Rheumatic Diseases 75 (6): 1016–1023.
APA
Moltó, A., Etcheto, A., van der Heijde, D., Landewé, R., Van den Bosch, F., Bautista Molano, W., Burgos-Vargas, R., et al. (2015). Prevalence of comorbidities and evaluation of their screening in spondyloarthritis : results of the international cross-sectional ASAS-COMOSPA study. ANNALS OF THE RHEUMATIC DISEASES, 75(6), 1016–1023.
Vancouver
1.
Moltó A, Etcheto A, van der Heijde D, Landewé R, Van den Bosch F, Bautista Molano W, et al. Prevalence of comorbidities and evaluation of their screening in spondyloarthritis : results of the international cross-sectional ASAS-COMOSPA study. ANNALS OF THE RHEUMATIC DISEASES. 2015;75(6):1016–23.
MLA
Moltó, Anna, Adrien Etcheto, Désirée van der Heijde, et al. “Prevalence of Comorbidities and Evaluation of Their Screening in Spondyloarthritis : Results of the International Cross-sectional ASAS-COMOSPA Study.” ANNALS OF THE RHEUMATIC DISEASES 75.6 (2015): 1016–1023. Print.
@article{8501062,
  abstract     = {Background: Increased risk of some comorbidities has been reported in spondyloarthritis (SpA). Recommendations for detection/management of some of these comorbidities have been proposed, and it is known that a gap exists between these and their implementation in practice. 
Objective: To evaluate (1) the prevalence of comorbidities and risk factors in different countries worldwide, (2) the gap between available recommendations and daily practice for management of these comorbidities and (3) the prevalence of previously unknown risk factors detected as a result of the present initiative. 
Methods: Cross-sectional international study with 22 participating countries (from four continents), including 3984 patients with SpA according to the rheumatologist. 
Statistical analysis: The prevalence of comorbidities (cardiovascular, infection, cancer, osteoporosis and gastrointestinal) and risk factors; percentage of patients optimally monitored for comorbidities according to available recommendations and percentage of patients for whom a risk factor was detected due to this study. 
Results: The most frequent comorbidities were osteoporosis (13\%) and gastroduodenal ulcer (11\%). The most frequent risk factors were hypertension (34\%), smoking (29\%) and hypercholesterolaemia (27\%). Substantial intercountry variability was observed for screening of comorbidities (eg, for LDL cholesterol measurement: from 8\% (Taiwan) to 98\% (Germany)). Systematic evaluation (eg, blood pressure (BP), cholesterol) during this study unveiled previously unknown risk factors (eg, elevated BP (14\%)), emphasising the suboptimal monitoring of comorbidities. 
Conclusions: A high prevalence of comorbidities in SpA has been shown. Rigorous application of systematic evaluation of comorbidities may permit earlier detection, which may ultimately result in an improved outcome of patients with SpA.},
  author       = {Molt{\'o}, Anna and Etcheto, Adrien and van der Heijde, D{\'e}sir{\'e}e and Landew{\'e}, Robert and Van den Bosch, Filip and Bautista Molano, Wilson and Burgos-Vargas, Ruben and Cheung, Peter P and Collantes-Estevez, Eduardo and Deodhar, Atul and El-Zorkany, Bassel and Erdes, Shandor and Gu, Jieruo and Hajjaj-Hassouni, Najia and Kiltz, Uta and Kim, Tae-Hwan and Kishimoto, Mitsumasa and Luo, Shue-Fen and Machado, Pedro M and Maksymowych, Walter P and Maldonado-Cocco, Jos{\'e} and Marzo-Ortega, Helena and Montecucco, Carlo-Maurizio and Ozgo\c{c}men, Salih and van Gaalen, Floris and Dougados, Maxime},
  issn         = {0003-4967},
  journal      = {ANNALS OF THE RHEUMATIC DISEASES},
  keyword      = {OF-THE-LITERATURE,POPULATION-BASED COHORT,BONE-MINERAL DENSITY,ANKYLOSING-SPONDYLITIS,RHEUMATOID-ARTHRITIS,BODY-COMPOSITION,CANCER INCIDENCE,HEART-DISEASE,RISK,RECOMMENDATIONS},
  language     = {eng},
  number       = {6},
  pages        = {1016--1023},
  title        = {Prevalence of comorbidities and evaluation of their screening in spondyloarthritis : results of the international cross-sectional ASAS-COMOSPA study},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2015-208174},
  volume       = {75},
  year         = {2015},
}

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