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AURORA : bariatric surgery registration in women of reproductive age : a multicenter prospective cohort study

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Abstract
Background: The expansion of the obesity epidemic is accompanied with an increase in bariatric procedures, in particular in women of reproductive age. The weight loss induced by the surgery is believed to reverse the negative impact of overweight and obesity on female reproduction, however, research is limited to in particular retrospective cohort studies and a growing number of small case-series and case-(control) studies. Methods/design: AURORA is a multicenter prospective cohort study. The main objective is to collect long-term data on reproductive outcomes before and after bariatric surgery and in a subsequent pregnancy. Women aged 18-45 years are invited to participate at 4 possible inclusion moments: 1) before surgery, 2) after surgery, 3) before 15 weeks of pregnancy and 4) in the immediate postpartum period (day 3-4). Depending on the time of inclusion, data are collected before surgery (T1), 3 weeks and 3, 6, 12 or x months after surgery (T2-T5) and during the first, second and third trimester of pregnancy (T6-T8), at delivery (T9) and 6 weeks and 6 months after delivery (T10-T11). Online questionnaires are send on the different measuring moments. Data are collected on contraception, menstrual cycle, sexuality, intention of becoming pregnant, diet, physical activity, lifestyle, psycho-social characteristics and dietary supplement intake. Fasting blood samples determine levels of vitamin A, D, E, K, B-1, B-12 and folate, albumin, total protein, coagulation parameters, magnesium, calcium, zinc and glucose. Participants are weighted every measuring moment. Fetal ultrasounds and pregnancy course and complications are reported every trimester of pregnancy. Breastfeeding is recorded and breast milk composition in the postpartum period is studied. Discussion: AURORA is a multicenter prospective cohort study extensively monitoring women before undergoing bariatric surgery until a subsequent pregnancy and postpartum period.
Keywords
GASTRIC BYPASS-SURGERY, PHYSICAL-ACTIVITY SURVEY, BREAST-MILK, NEONATAL, OUTCOMES, PREGNANT-WOMEN, MACRONUTRIENT COMPOSITION, VALIDATION, DEFICIENCY, COMPLICATIONS, QUESTIONNAIRE, Obesity, Bariatric surgery, Reproduction, Fertility, Contraception, Pregnancy, Breast feeding

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Chicago
Jans, Goele, Christophe Matthys, Sarah Bel, Lieveke Ameye, Matthias Lannoo, Bart Van der Schueren, Bruno Dillemans, et al. 2016. “AURORA : Bariatric Surgery Registration in Women of Reproductive Age : a Multicenter Prospective Cohort Study.” Bmc Pregnancy and Childbirth 16.
APA
Jans, G., Matthys, C., Bel, S., Ameye, L., Lannoo, M., Van der Schueren, B., Dillemans, B., et al. (2016). AURORA : bariatric surgery registration in women of reproductive age : a multicenter prospective cohort study. BMC PREGNANCY AND CHILDBIRTH, 16.
Vancouver
1.
Jans G, Matthys C, Bel S, Ameye L, Lannoo M, Van der Schueren B, et al. AURORA : bariatric surgery registration in women of reproductive age : a multicenter prospective cohort study. BMC PREGNANCY AND CHILDBIRTH. 2016;16.
MLA
Jans, Goele et al. “AURORA : Bariatric Surgery Registration in Women of Reproductive Age : a Multicenter Prospective Cohort Study.” BMC PREGNANCY AND CHILDBIRTH 16 (2016): n. pag. Print.
@article{8500641,
  abstract     = {Background: The expansion of the obesity epidemic is accompanied with an increase in bariatric procedures, in particular in women of reproductive age. The weight loss induced by the surgery is believed to reverse the negative impact of overweight and obesity on female reproduction, however, research is limited to in particular retrospective cohort studies and a growing number of small case-series and case-(control) studies. 
Methods/design: AURORA is a multicenter prospective cohort study. The main objective is to collect long-term data on reproductive outcomes before and after bariatric surgery and in a subsequent pregnancy. Women aged 18-45 years are invited to participate at 4 possible inclusion moments: 1) before surgery, 2) after surgery, 3) before 15 weeks of pregnancy and 4) in the immediate postpartum period (day 3-4). Depending on the time of inclusion, data are collected before surgery (T1), 3 weeks and 3, 6, 12 or x months after surgery (T2-T5) and during the first, second and third trimester of pregnancy (T6-T8), at delivery (T9) and 6 weeks and 6 months after delivery (T10-T11). Online questionnaires are send on the different measuring moments. Data are collected on contraception, menstrual cycle, sexuality, intention of becoming pregnant, diet, physical activity, lifestyle, psycho-social characteristics and dietary supplement intake. Fasting blood samples determine levels of vitamin A, D, E, K, B-1, B-12 and folate, albumin, total protein, coagulation parameters, magnesium, calcium, zinc and glucose. Participants are weighted every measuring moment. Fetal ultrasounds and pregnancy course and complications are reported every trimester of pregnancy. Breastfeeding is recorded and breast milk composition in the postpartum period is studied. 
Discussion: AURORA is a multicenter prospective cohort study extensively monitoring women before undergoing bariatric surgery until a subsequent pregnancy and postpartum period.},
  articleno    = {195},
  author       = {Jans, Goele and Matthys, Christophe and Bel, Sarah and Ameye, Lieveke and Lannoo, Matthias and Van der Schueren, Bart and Dillemans, Bruno and Lemmens, Luc and Saey, Jean-Pierre and Van Nieuwenhove, Yves and Grandjean, Pascale and De Becker, Ben and Logghe, Hilde and Coppens, Marc and Roelens, Kristien and Loccufier, Anne and Verhaeghe, Johan and Devlieger, Roland},
  issn         = {1471-2393},
  journal      = {BMC PREGNANCY AND CHILDBIRTH},
  keywords     = {GASTRIC BYPASS-SURGERY,PHYSICAL-ACTIVITY SURVEY,BREAST-MILK,NEONATAL,OUTCOMES,PREGNANT-WOMEN,MACRONUTRIENT COMPOSITION,VALIDATION,DEFICIENCY,COMPLICATIONS,QUESTIONNAIRE,Obesity,Bariatric surgery,Reproduction,Fertility,Contraception,Pregnancy,Breast feeding},
  language     = {eng},
  pages        = {11},
  title        = {AURORA : bariatric surgery registration in women of reproductive age : a multicenter prospective cohort study},
  url          = {http://dx.doi.org/10.1186/s12884-016-0992-y},
  volume       = {16},
  year         = {2016},
}

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