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Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Chika Honda, Jacob vB Hjelmborg, Sören Möller, Syuichi Ooki, Sari Aaltonen, et al. (2016) AMERICAN JOURNAL OF CLINICAL NUTRITION. 104(2). p.371-379
abstract
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CHILDHOOD OBESITY, HEIGHT, BMI, HERITABILITY, COUNTRIES, WEIGHT, AGE, BMI, children, genetics, international comparisons, twins
journal title
AMERICAN JOURNAL OF CLINICAL NUTRITION
Am. J. Clin. Nutr.
volume
104
issue
2
pages
371 - 379
Web of Science type
Article
Web of Science id
000381870200017
JCR category
NUTRITION & DIETETICS
JCR impact factor
6.926 (2016)
JCR rank
3/81 (2016)
JCR quartile
1 (2016)
ISSN
0002-9165
1938-3207
DOI
10.3945/ajcn.116.130252
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8500582
handle
http://hdl.handle.net/1854/LU-8500582
date created
2017-01-06 08:59:37
date last changed
2017-03-07 15:12:02
@article{8500582,
  abstract     = {Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. 
Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. 
Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. 
Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. 
Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.},
  author       = {Silventoinen, Karri and Jelenkovic, Aline and Sund, Reijo and Hur, Yoon-Mi and Yokoyama, Yoshie and Honda, Chika and Hjelmborg, Jacob vB and M{\"o}ller, S{\"o}ren and Ooki, Syuichi and Aaltonen, Sari and Ji, Fuling and Ning, Feng and Pang, Zengchang and Rebato, Esther and Busjahn, Andreas and Kandler, Christian and Saudino, Kimberly J and Jang, Kerry L and Cozen, Wendy and Hwang, Amie E and Mack, Thomas M and Gao, Wenjing and Yu, Canqing and Li, Liming and Corley, Robin P and Huibregtse, Brooke M and Christensen, Kaare and Skytthe, Axel and Kyvik, Kirsten O and Derom, Catherine and Vlietinck, Robert F and Loos, Ruth JF and Heikkila, Kauko and Wardle, Jane and Llewellyn, Clare H and Fisher, Abigail and McAdams, Tom A and Eley, Thalia C and Gregory, Alice M and He, Mingguang and Ding, Xiaohu and Bjerregaard-Andersen, Morten and Beck-Nielsen, Henning and Sodemann, Morten and Tarnoki, Adam D and Tarnoki, David L and Stazi, Maria A and Fagnani, Corrado and D'Ippolito, Cristina and Knafo-Noam, Ariel and Mankuta, David and Abramson, Lior and Burt, S Alexandra and Klump, Kelly L and Silberg, Judy L and Eaves, Lindon J and Maes, Hermine H and Krueger, Robert F and McGue, Matt and Pahlen, Shandell and Gatz, Margaret and Butler, David A and Bartels, Meike and van Beijsterveldt, Toos CEM and Craig, Jeffrey M and Saffery, Richard and Freitas, Duarte L and Maia, Jos{\'e} Antonio and Dubois, Lise and Boivin, Michel and Brendgen, Mara and Dionne, Ginette and Vitaro, Frank and Martin, Nicholas G and Medland, Sarah E and Montgomery, Grant W and Chong, Youngsook and Swan, Gary E and Krasnow, Ruth and Magnusson, Patrik KE and Pedersen, Nancy L and Tynelius, Per and Lichtenstein, Paul and Haworth, Claire MA and Plomin, Robert and Bayasgalan, Gombojav and Narandalai, Danshiitsoodol and Harden, K Paige and Tucker-Drob, Elliot M and {\"O}ncel, Sevgi Y and Aliev, Fazil and Spector, Timothy and Mangino, Massimo and Lachance, Genevieve and Baker, Laura A and Tuvblad, Catherine and Duncan, Glen E and Buchwald, Dedra and Willemsen, Gonneke and Rasmussen, Finn and Goldberg, Jack H and S{\o}rensen, Thorkild IA and Boomsma, Dorret I and Kaprio, Jaakko},
  issn         = {0002-9165},
  journal      = {AMERICAN JOURNAL OF CLINICAL NUTRITION},
  keyword      = {CHILDHOOD OBESITY,HEIGHT,BMI,HERITABILITY,COUNTRIES,WEIGHT,AGE,BMI,children,genetics,international comparisons,twins},
  language     = {eng},
  number       = {2},
  pages        = {371--379},
  title        = {Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study},
  url          = {http://dx.doi.org/10.3945/ajcn.116.130252},
  volume       = {104},
  year         = {2016},
}

Chicago
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Chika Honda, Jacob vb Hjelmborg, et al. 2016. “Genetic and Environmental Effects on Body Mass Index from Infancy to the Onset of Adulthood : an Individual-based Pooled Analysis of 45 Twin Cohorts Participating in the COllaborative Project of Development of Anthropometrical Measures in Twins (CODATwins) Study.” American Journal of Clinical Nutrition 104 (2): 371–379.
APA
Silventoinen, K., Jelenkovic, A., Sund, R., Hur, Y.-M., Yokoyama, Y., Honda, C., Hjelmborg, J. vB, et al. (2016). Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. AMERICAN JOURNAL OF CLINICAL NUTRITION, 104(2), 371–379.
Vancouver
1.
Silventoinen K, Jelenkovic A, Sund R, Hur Y-M, Yokoyama Y, Honda C, et al. Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 2016;104(2):371–9.
MLA
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, et al. “Genetic and Environmental Effects on Body Mass Index from Infancy to the Onset of Adulthood : an Individual-based Pooled Analysis of 45 Twin Cohorts Participating in the COllaborative Project of Development of Anthropometrical Measures in Twins (CODATwins) Study.” AMERICAN JOURNAL OF CLINICAL NUTRITION 104.2 (2016): 371–379. Print.