Advanced search
1 file | 877.52 KB Add to list

Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Author
Organization
Abstract
Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.
Keywords
CHILDHOOD OBESITY, HEIGHT, BMI, HERITABILITY, COUNTRIES, WEIGHT, AGE, BMI, children, genetics, international comparisons, twins

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 877.52 KB

Citation

Please use this url to cite or link to this publication:

MLA
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, et al. “Genetic and Environmental Effects on Body Mass Index from Infancy to the Onset of Adulthood : an Individual-based Pooled Analysis of 45 Twin Cohorts Participating in the COllaborative Project of Development of Anthropometrical Measures in Twins (CODATwins) Study.” AMERICAN JOURNAL OF CLINICAL NUTRITION 104.2 (2016): 371–379. Print.
APA
Silventoinen, K., Jelenkovic, A., Sund, R., Hur, Y.-M., Yokoyama, Y., Honda, C., Hjelmborg, J. vB, et al. (2016). Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. AMERICAN JOURNAL OF CLINICAL NUTRITION, 104(2), 371–379.
Chicago author-date
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Chika Honda, Jacob vb Hjelmborg, et al. 2016. “Genetic and Environmental Effects on Body Mass Index from Infancy to the Onset of Adulthood : an Individual-based Pooled Analysis of 45 Twin Cohorts Participating in the COllaborative Project of Development of Anthropometrical Measures in Twins (CODATwins) Study.” American Journal of Clinical Nutrition 104 (2): 371–379.
Chicago author-date (all authors)
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Chika Honda, Jacob vb Hjelmborg, Sören Möller, Syuichi Ooki, Sari Aaltonen, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Andreas Busjahn, Christian Kandler, Kimberly J Saudino, Kerry L Jang, Wendy Cozen, Amie E Hwang, Thomas M Mack, Wenjing Gao, Canqing Yu, Liming Li, Robin P Corley, Brooke M Huibregtse, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Catherine Derom, Robert F Vlietinck, Ruth JF Loos, Kauko Heikkila, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Tom A McAdams, Thalia C Eley, Alice M Gregory, Mingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, Maria A Stazi, Corrado Fagnani, Cristina D’Ippolito, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Robert F Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A Butler, Meike Bartels, Toos CEM van Beijsterveldt, Jeffrey M Craig, Richard Saffery, Duarte L Freitas, José Antonio Maia, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Youngsook Chong, Gary E Swan, Ruth Krasnow, Patrik KE Magnusson, Nancy L Pedersen, Per Tynelius, Paul Lichtenstein, Claire MA Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, K Paige Harden, Elliot M Tucker-Drob, Sevgi Y Öncel, Fazil Aliev, Timothy Spector, Massimo Mangino, Genevieve Lachance, Laura A Baker, Catherine Tuvblad, Glen E Duncan, Dedra Buchwald, Gonneke Willemsen, Finn Rasmussen, Jack H Goldberg, Thorkild IA Sørensen, Dorret I Boomsma, and Jaakko Kaprio. 2016. “Genetic and Environmental Effects on Body Mass Index from Infancy to the Onset of Adulthood : an Individual-based Pooled Analysis of 45 Twin Cohorts Participating in the COllaborative Project of Development of Anthropometrical Measures in Twins (CODATwins) Study.” American Journal of Clinical Nutrition 104 (2): 371–379.
Vancouver
1.
Silventoinen K, Jelenkovic A, Sund R, Hur Y-M, Yokoyama Y, Honda C, et al. Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. AMERICAN JOURNAL OF CLINICAL NUTRITION. 2016;104(2):371–9.
IEEE
[1]
K. Silventoinen et al., “Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study,” AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 104, no. 2, pp. 371–379, 2016.
@article{8500582,
  abstract     = {Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. 
Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. 
Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. 
Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a(2) = 0.42) and girls (a(2) = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. 
Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.},
  author       = {Silventoinen, Karri and Jelenkovic, Aline and Sund, Reijo and Hur, Yoon-Mi and Yokoyama, Yoshie and Honda, Chika and Hjelmborg, Jacob vB and Möller, Sören and Ooki, Syuichi and Aaltonen, Sari and Ji, Fuling and Ning, Feng and Pang, Zengchang and Rebato, Esther and Busjahn, Andreas and Kandler, Christian and Saudino, Kimberly J and Jang, Kerry L and Cozen, Wendy and Hwang, Amie E and Mack, Thomas M and Gao, Wenjing and Yu, Canqing and Li, Liming and Corley, Robin P and Huibregtse, Brooke M and Christensen, Kaare and Skytthe, Axel and Kyvik, Kirsten O and Derom, Catherine and Vlietinck, Robert F and Loos, Ruth JF and Heikkila, Kauko and Wardle, Jane and Llewellyn, Clare H and Fisher, Abigail and McAdams, Tom A and Eley, Thalia C and Gregory, Alice M and He, Mingguang and Ding, Xiaohu and Bjerregaard-Andersen, Morten and Beck-Nielsen, Henning and Sodemann, Morten and Tarnoki, Adam D and Tarnoki, David L and Stazi, Maria A and Fagnani, Corrado and D'Ippolito, Cristina and Knafo-Noam, Ariel and Mankuta, David and Abramson, Lior and Burt, S Alexandra and Klump, Kelly L and Silberg, Judy L and Eaves, Lindon J and Maes, Hermine H and Krueger, Robert F and McGue, Matt and Pahlen, Shandell and Gatz, Margaret and Butler, David A and Bartels, Meike and van Beijsterveldt, Toos CEM and Craig, Jeffrey M and Saffery, Richard and Freitas, Duarte L and Maia, José Antonio and Dubois, Lise and Boivin, Michel and Brendgen, Mara and Dionne, Ginette and Vitaro, Frank and Martin, Nicholas G and Medland, Sarah E and Montgomery, Grant W and Chong, Youngsook and Swan, Gary E and Krasnow, Ruth and Magnusson, Patrik KE and Pedersen, Nancy L and Tynelius, Per and Lichtenstein, Paul and Haworth, Claire MA and Plomin, Robert and Bayasgalan, Gombojav and Narandalai, Danshiitsoodol and Harden, K Paige and Tucker-Drob, Elliot M and Öncel, Sevgi Y and Aliev, Fazil and Spector, Timothy and Mangino, Massimo and Lachance, Genevieve and Baker, Laura A and Tuvblad, Catherine and Duncan, Glen E and Buchwald, Dedra and Willemsen, Gonneke and Rasmussen, Finn and Goldberg, Jack H and Sørensen, Thorkild IA and Boomsma, Dorret I and Kaprio, Jaakko},
  issn         = {0002-9165},
  journal      = {AMERICAN JOURNAL OF CLINICAL NUTRITION},
  keywords     = {CHILDHOOD OBESITY,HEIGHT,BMI,HERITABILITY,COUNTRIES,WEIGHT,AGE,BMI,children,genetics,international comparisons,twins},
  language     = {eng},
  number       = {2},
  pages        = {371--379},
  title        = {Genetic and environmental effects on body mass index from infancy to the onset of adulthood : an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study},
  url          = {http://dx.doi.org/10.3945/ajcn.116.130252},
  volume       = {104},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: