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Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression

(2016) CEREBRAL CORTEX. 26(2). p.510-516
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Abstract
Although the prevailing opinion is that emotional processes are influenced by sex hormones, the literature is still inconclusive. The aim of the current study was to examine the effects of gonadal suppression on brain activity during affective picture processing. Twenty-one female-to-male (FtM) transsexuals and 19 control women were recruited and underwent functional magnetic resonance imaging scanning while rating emotional pictures adapted from the International Affective Picture System. The gonadal hormone production of the FtMs was suppressed for 8 weeks, the control group did not receive any treatment before scanning. Under gonadal suppression, FtMs showed less brain activation in the superior temporal lobe compared with female controls during perception of positive affective pictures. Regression analysis showed that during processing of positive affective images, brain activity within the right superior temporal lobe was not correlated with levels of estradiol, luteinizing hormone, and follicle-stimulating hormone. In the absence of associations with hormonal levels, the difference in activation in the superior temporal lobe during positive emotional stimuli between FtMs and control women may be attributed to a priori differences between the 2 groups. Future studies should clarify if these differences are a result of atypical sexual differentiation of the brain in FtMs.
Keywords
SEX-DIFFERENCES, GENDER-DIFFERENCES, NEURAL RESPONSES, HORMONAL CYCLE, VISUAL-STIMULI, ACTIVATION, EMPATHY, HUMANS, CORTEX, PERCEPTION, emotional processing, functional MRI, gender dysphoria, gender identity, disorder, GnRH suppression, sex steroids

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Chicago
Soleman, RS, AS Staphorsius, PT Cohen-Kettenis, Cornelis Lambalk, DJ Veltman, MAA van Trotsenburg, PGA Hompes, ML Drent, WP de Ronde, and BPC Kreukels. 2016. “Oestrogens Are Not Related to Emotional Processing : a Study of Regional Brain Activity in Female-to-male Transsexuals Under Gonadal Suppression.” Cerebral Cortex 26 (2): 510–516.
APA
Soleman, R., Staphorsius, A., Cohen-Kettenis, P., Lambalk, C., Veltman, D., van Trotsenburg, M., Hompes, P., et al. (2016). Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression. CEREBRAL CORTEX, 26(2), 510–516.
Vancouver
1.
Soleman R, Staphorsius A, Cohen-Kettenis P, Lambalk C, Veltman D, van Trotsenburg M, et al. Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression. CEREBRAL CORTEX. 2016;26(2):510–6.
MLA
Soleman, RS, AS Staphorsius, PT Cohen-Kettenis, et al. “Oestrogens Are Not Related to Emotional Processing : a Study of Regional Brain Activity in Female-to-male Transsexuals Under Gonadal Suppression.” CEREBRAL CORTEX 26.2 (2016): 510–516. Print.
@article{8500491,
  abstract     = {Although the prevailing opinion is that emotional processes are influenced by sex hormones, the literature is still inconclusive. The aim of the current study was to examine the effects of gonadal suppression on brain activity during affective picture processing. Twenty-one female-to-male (FtM) transsexuals and 19 control women were recruited and underwent functional magnetic resonance imaging scanning while rating emotional pictures adapted from the International Affective Picture System. The gonadal hormone production of the FtMs was suppressed for 8 weeks, the control group did not receive any treatment before scanning. Under gonadal suppression, FtMs showed less brain activation in the superior temporal lobe compared with female controls during perception of positive affective pictures. Regression analysis showed that during processing of positive affective images, brain activity within the right superior temporal lobe was not correlated with levels of estradiol, luteinizing hormone, and follicle-stimulating hormone. In the absence of associations with hormonal levels, the difference in activation in the superior temporal lobe during positive emotional stimuli between FtMs and control women may be attributed to a priori differences between the 2 groups. Future studies should clarify if these differences are a result of atypical sexual differentiation of the brain in FtMs.},
  author       = {Soleman, RS and Staphorsius, AS and Cohen-Kettenis, PT and Lambalk, Cornelis and Veltman, DJ and van Trotsenburg, MAA and Hompes, PGA and Drent, ML and de Ronde, WP and Kreukels, BPC},
  issn         = {1047-3211},
  journal      = {CEREBRAL CORTEX},
  keyword      = {SEX-DIFFERENCES,GENDER-DIFFERENCES,NEURAL RESPONSES,HORMONAL CYCLE,VISUAL-STIMULI,ACTIVATION,EMPATHY,HUMANS,CORTEX,PERCEPTION,emotional processing,functional MRI,gender dysphoria,gender identity,disorder,GnRH suppression,sex steroids},
  language     = {eng},
  number       = {2},
  pages        = {510--516},
  title        = {Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression},
  url          = {http://dx.doi.org/10.1093/cercor/bhu201},
  volume       = {26},
  year         = {2016},
}

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