Ghent University Academic Bibliography

Advanced

Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression

RS Soleman, AS Staphorsius, PT Cohen-Kettenis, Cornelis Lambalk UGent, DJ Veltman, MAA van Trotsenburg, PGA Hompes, ML Drent, WP de Ronde and BPC Kreukels (2016) CEREBRAL CORTEX. 26(2). p.510-516
abstract
Although the prevailing opinion is that emotional processes are influenced by sex hormones, the literature is still inconclusive. The aim of the current study was to examine the effects of gonadal suppression on brain activity during affective picture processing. Twenty-one female-to-male (FtM) transsexuals and 19 control women were recruited and underwent functional magnetic resonance imaging scanning while rating emotional pictures adapted from the International Affective Picture System. The gonadal hormone production of the FtMs was suppressed for 8 weeks, the control group did not receive any treatment before scanning. Under gonadal suppression, FtMs showed less brain activation in the superior temporal lobe compared with female controls during perception of positive affective pictures. Regression analysis showed that during processing of positive affective images, brain activity within the right superior temporal lobe was not correlated with levels of estradiol, luteinizing hormone, and follicle-stimulating hormone. In the absence of associations with hormonal levels, the difference in activation in the superior temporal lobe during positive emotional stimuli between FtMs and control women may be attributed to a priori differences between the 2 groups. Future studies should clarify if these differences are a result of atypical sexual differentiation of the brain in FtMs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SEX-DIFFERENCES, GENDER-DIFFERENCES, NEURAL RESPONSES, HORMONAL CYCLE, VISUAL-STIMULI, ACTIVATION, EMPATHY, HUMANS, CORTEX, PERCEPTION, emotional processing, functional MRI, gender dysphoria, gender identity, disorder, GnRH suppression, sex steroids
journal title
CEREBRAL CORTEX
Cereb. Cortex
volume
26
issue
2
pages
510 - 516
Web of Science type
Article
Web of Science id
000371522500005
JCR category
NEUROSCIENCES
JCR impact factor
6.559 (2016)
JCR rank
20/258 (2016)
JCR quartile
1 (2016)
ISSN
1047-3211
1460-2199
DOI
10.1093/cercor/bhu201
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8500491
handle
http://hdl.handle.net/1854/LU-8500491
date created
2017-01-05 12:41:44
date last changed
2017-01-11 12:51:01
@article{8500491,
  abstract     = {Although the prevailing opinion is that emotional processes are influenced by sex hormones, the literature is still inconclusive. The aim of the current study was to examine the effects of gonadal suppression on brain activity during affective picture processing. Twenty-one female-to-male (FtM) transsexuals and 19 control women were recruited and underwent functional magnetic resonance imaging scanning while rating emotional pictures adapted from the International Affective Picture System. The gonadal hormone production of the FtMs was suppressed for 8 weeks, the control group did not receive any treatment before scanning. Under gonadal suppression, FtMs showed less brain activation in the superior temporal lobe compared with female controls during perception of positive affective pictures. Regression analysis showed that during processing of positive affective images, brain activity within the right superior temporal lobe was not correlated with levels of estradiol, luteinizing hormone, and follicle-stimulating hormone. In the absence of associations with hormonal levels, the difference in activation in the superior temporal lobe during positive emotional stimuli between FtMs and control women may be attributed to a priori differences between the 2 groups. Future studies should clarify if these differences are a result of atypical sexual differentiation of the brain in FtMs.},
  author       = {Soleman, RS and Staphorsius, AS and Cohen-Kettenis, PT and Lambalk, Cornelis and Veltman, DJ and van Trotsenburg, MAA and Hompes, PGA and Drent, ML and de Ronde, WP and Kreukels, BPC},
  issn         = {1047-3211},
  journal      = {CEREBRAL CORTEX},
  keyword      = {SEX-DIFFERENCES,GENDER-DIFFERENCES,NEURAL RESPONSES,HORMONAL CYCLE,VISUAL-STIMULI,ACTIVATION,EMPATHY,HUMANS,CORTEX,PERCEPTION,emotional processing,functional MRI,gender dysphoria,gender identity,disorder,GnRH suppression,sex steroids},
  language     = {eng},
  number       = {2},
  pages        = {510--516},
  title        = {Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression},
  url          = {http://dx.doi.org/10.1093/cercor/bhu201},
  volume       = {26},
  year         = {2016},
}

Chicago
Soleman, RS, AS Staphorsius, PT Cohen-Kettenis, Cornelis Lambalk, DJ Veltman, MAA van Trotsenburg, PGA Hompes, ML Drent, WP de Ronde, and BPC Kreukels. 2016. “Oestrogens Are Not Related to Emotional Processing : a Study of Regional Brain Activity in Female-to-male Transsexuals Under Gonadal Suppression.” Cerebral Cortex 26 (2): 510–516.
APA
Soleman, R., Staphorsius, A., Cohen-Kettenis, P., Lambalk, C., Veltman, D., van Trotsenburg, M., Hompes, P., et al. (2016). Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression. CEREBRAL CORTEX, 26(2), 510–516.
Vancouver
1.
Soleman R, Staphorsius A, Cohen-Kettenis P, Lambalk C, Veltman D, van Trotsenburg M, et al. Oestrogens are not related to emotional processing : a study of regional brain activity in female-to-male transsexuals under gonadal suppression. CEREBRAL CORTEX. 2016;26(2):510–6.
MLA
Soleman, RS, AS Staphorsius, PT Cohen-Kettenis, et al. “Oestrogens Are Not Related to Emotional Processing : a Study of Regional Brain Activity in Female-to-male Transsexuals Under Gonadal Suppression.” CEREBRAL CORTEX 26.2 (2016): 510–516. Print.