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Spared internal but impaired external reward prediction error signals in major depressive disorder during reinforcement learning

Jasmina Bakic, Gilles Pourtois UGent, Marieke Jepma, Romain Duprat UGent, Rudi De Raedt UGent and Chris Baeken UGent (2017) DEPRESSION AND ANXIETY . 34(1). p.89-96
abstract
Background: Major depressive disorder (MDD) creates debilitating effects on a wide range of cognitive functions, including reinforcement learning (RL). In this study, we sought to assess whether reward processing as such, or alternatively the complex interplay between motivation and reward might potentially account for the abnormal reward-based learning in MDD. Methods: A total of 35 treatment resistant MDD patients and 44 age matched healthy controls (HCs) performed a standard probabilistic learning task. RL was titrated using behavioral, computational modeling and event-related brain potentials (ERPs) data. Results: MDD patients showed comparable learning rate compared to HCs. However, they showed decreased lose-shift responses as well as blunted subjective evaluations of the reinforcers used during the task, relative to HCs. Moreover, MDD patients showed normal internal (at the level of error-related negativity, ERN) but abnormal external (at the level of feedback-related negativity, FRN) reward prediction error (RPE) signals during RL, selectively when additional efforts had to be made to establish learning. Conclusions: Collectively, these results lend support to the assumption that MDD does not impair reward processing per se during RL. Instead, it seems to alter the processing of the emotional value of (external) reinforcers during RL, when additional intrinsic motivational processes have to be engaged.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cognition, depression, EEG, evoked potentials, MONITORING FUNCTIONS, DECISION-MAKING, TASK, NEGATIVITY, ANHEDONIA, DOPAMINE, PLEASURE, MODEL, SCALE, ERN
journal title
DEPRESSION AND ANXIETY
Depress Anxiety
volume
34
issue
1
pages
89 - 96
publisher
Wiley-Blackwell
Web of Science type
Article
Web of Science id
000393774000009
ISSN
1091-4269
DOI
10.1002/da.22576
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8500481
handle
http://hdl.handle.net/1854/LU-8500481
date created
2017-01-05 11:39:39
date last changed
2017-03-16 13:04:34
@article{8500481,
  abstract     = {Background: Major depressive disorder (MDD) creates debilitating effects on a wide range of cognitive functions, including reinforcement learning (RL). In this study, we sought to assess whether reward processing as such, or alternatively the complex interplay between motivation and reward might potentially account for the abnormal reward-based learning in MDD. 
Methods: A total of 35 treatment resistant MDD patients and 44 age matched healthy controls (HCs) performed a standard probabilistic learning task. RL was titrated using behavioral, computational modeling and event-related brain potentials (ERPs) data. 
Results: MDD patients showed comparable learning rate compared to HCs. However, they showed decreased lose-shift responses as well as blunted subjective evaluations of the reinforcers used during the task, relative to HCs. Moreover, MDD patients showed normal internal (at the level of error-related negativity, ERN) but abnormal external (at the level of feedback-related negativity, FRN) reward prediction error (RPE) signals during RL, selectively when additional efforts had to be made to establish learning. 
Conclusions: Collectively, these results lend support to the assumption that MDD does not impair reward processing per se during RL. Instead, it seems to alter the processing of the emotional value of (external) reinforcers during RL, when additional intrinsic motivational processes have to be engaged.},
  author       = {Bakic, Jasmina and Pourtois, Gilles and Jepma, Marieke and Duprat, Romain and De Raedt, Rudi and Baeken, Chris},
  issn         = {1091-4269},
  journal      = {DEPRESSION AND ANXIETY                                            },
  keyword      = {cognition,depression,EEG,evoked potentials,MONITORING FUNCTIONS,DECISION-MAKING,TASK,NEGATIVITY,ANHEDONIA,DOPAMINE,PLEASURE,MODEL,SCALE,ERN},
  language     = {eng},
  number       = {1},
  pages        = {89--96},
  publisher    = {Wiley-Blackwell},
  title        = {Spared internal but impaired external reward prediction error signals in major depressive disorder during reinforcement learning},
  url          = {http://dx.doi.org/10.1002/da.22576},
  volume       = {34},
  year         = {2017},
}

Chicago
Bakic, Jasmina, Gilles Pourtois, Marieke Jepma, Romain Duprat, Rudi De Raedt, and Chris Baeken. 2017. “Spared Internal but Impaired External Reward Prediction Error Signals in Major Depressive Disorder During Reinforcement Learning.” Depression and Anxiety  34 (1): 89–96.
APA
Bakic, J., Pourtois, G., Jepma, M., Duprat, R., De Raedt, R., & Baeken, C. (2017). Spared internal but impaired external reward prediction error signals in major depressive disorder during reinforcement learning. DEPRESSION AND ANXIETY  , 34(1), 89–96.
Vancouver
1.
Bakic J, Pourtois G, Jepma M, Duprat R, De Raedt R, Baeken C. Spared internal but impaired external reward prediction error signals in major depressive disorder during reinforcement learning. DEPRESSION AND ANXIETY  . Wiley-Blackwell; 2017;34(1):89–96.
MLA
Bakic, Jasmina, Gilles Pourtois, Marieke Jepma, et al. “Spared Internal but Impaired External Reward Prediction Error Signals in Major Depressive Disorder During Reinforcement Learning.” DEPRESSION AND ANXIETY  34.1 (2017): 89–96. Print.