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Allostatic load and preterm birth

David M Olson, Emily M Severson, Barbara Verstraeten UGent, Jane WY Ng, J Keiko McCreary and Gerlinde AS Metz (2015) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 16(12). p.29856-29874
abstract
Preterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when pregnancy begins or when women will actually deliver. Until these problems are addressed, there will be no interventions to reduce the risk because those who should be treated will not be known. Considerable evidence now exists that chronic life, generational or accumulated stress is a risk factor for preterm delivery in animal models and in women. This wear and tear on the body and mind is called allostatic load. This review explores the evidence that chronic stress contributes to preterm birth and other adverse pregnancy outcomes in animal and human studies. It explores how allostatic load can be used to, firstly, model stress and preterm birth in animal models and, secondly, how it can be used to develop a predictive model to assess relative risk among women in early pregnancy. Once care providers know who is in the highest risk group, interventions can be developed and applied to mitigate their risk.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2, EPIGENETIC, TRANSGENERATIONAL INHERITANCE, 2-HIT HYPOTHESIS, WEIGHT INFANTS, CHRONIC, STRESS, PREGNANCY, DISEASE, OUTCOMES, HEALTH, MEDIATORS, allostatic load, allostasis, chronic stress, preterm birth, inflammation, two hits, multiple hit hypothesis, adverse pregnancy, outcomes
journal title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Int. J. Mol. Sci.
volume
16
issue
12
pages
29856 - 29874
Web of Science type
Review
Web of Science id
000367535600122
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
3.257 (2015)
JCR rank
51/163 (2015)
JCR quartile
2 (2015)
ISSN
1422-0067
DOI
10.3390/ijms161226209
language
English
UGent publication?
no
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
8500471
handle
http://hdl.handle.net/1854/LU-8500471
date created
2017-01-05 10:20:15
date last changed
2017-05-12 08:08:07
@article{8500471,
  abstract     = {Preterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when pregnancy begins or when women will actually deliver. Until these problems are addressed, there will be no interventions to reduce the risk because those who should be treated will not be known. Considerable evidence now exists that chronic life, generational or accumulated stress is a risk factor for preterm delivery in animal models and in women. This wear and tear on the body and mind is called allostatic load. This review explores the evidence that chronic stress contributes to preterm birth and other adverse pregnancy outcomes in animal and human studies. It explores how allostatic load can be used to, firstly, model stress and preterm birth in animal models and, secondly, how it can be used to develop a predictive model to assess relative risk among women in early pregnancy. Once care providers know who is in the highest risk group, interventions can be developed and applied to mitigate their risk.},
  author       = {Olson, David M and Severson, Emily M and Verstraeten, Barbara and Ng, Jane WY and McCreary, J Keiko and Metz, Gerlinde AS},
  issn         = {1422-0067},
  journal      = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
  keyword      = {11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2,EPIGENETIC,TRANSGENERATIONAL INHERITANCE,2-HIT HYPOTHESIS,WEIGHT INFANTS,CHRONIC,STRESS,PREGNANCY,DISEASE,OUTCOMES,HEALTH,MEDIATORS,allostatic load,allostasis,chronic stress,preterm birth,inflammation,two hits,multiple hit hypothesis,adverse pregnancy,outcomes},
  language     = {eng},
  number       = {12},
  pages        = {29856--29874},
  title        = {Allostatic load and preterm birth},
  url          = {http://dx.doi.org/10.3390/ijms161226209},
  volume       = {16},
  year         = {2015},
}

Chicago
Olson, David M, Emily M Severson, Barbara Verstraeten, Jane WY Ng, J Keiko McCreary, and Gerlinde AS Metz. 2015. “Allostatic Load and Preterm Birth.” International Journal of Molecular Sciences 16 (12): 29856–29874.
APA
Olson, D. M., Severson, E. M., Verstraeten, B., Ng, J. W., McCreary, J. K., & Metz, G. A. (2015). Allostatic load and preterm birth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16(12), 29856–29874.
Vancouver
1.
Olson DM, Severson EM, Verstraeten B, Ng JW, McCreary JK, Metz GA. Allostatic load and preterm birth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015;16(12):29856–74.
MLA
Olson, David M, Emily M Severson, Barbara Verstraeten, et al. “Allostatic Load and Preterm Birth.” INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.12 (2015): 29856–29874. Print.