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Efficacy of tiotropium-olodaterol fixed-dose combination in COPD

Eric Derom (UGent) , Guy Brusselle (UGent) and Guy Joos (UGent)
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Abstract
Tiotropium-olodaterol, formulated in the Respimat soft-mist inhaler, is an inhaled fixed-dose combination (FDC) of a long-acting muscarinic antagonist (LAMA) and a long-acting beta(2)-agonist (LABA), commercialized under the name of Spiolto or Stiolto. The efficacy of tiotropium-olodaterol 5-5 mu g once daily in adult patients with COPD was documented in eleven large, multicenter trials of up to 52 weeks duration. Tiotropium-olodaterol 5-5 mu g not only improved spirometric values to a significantly greater extent than placebo but also resulted in statistically significant beneficial effects on dyspnea, markers of hyperinflation, use of rescue medication, health-related quality of life, and exercise endurance. Improvements exceeded the minimal clinically important difference (MCID) for forced expiratory volume in 1 second (FEV1), dyspnea, and quality of life. Differences between tiotropium-olodaterol 5-5 mu g and the respective monocomponents were statistically significant for FEV1, dyspnea, markers of hyperinflation, use of rescue medication, and health-related quality of life, but did not reach the MCID. However, dual bronchodilatation significantly increased the number of patients who exceeded the MCID for dyspnea and quality of life. Moreover, tiotropium-olodaterol 5-5 mu g was significantly more effective than salmeterol-fluticasone (FDC) twice daily at improving pulmonary function. Differences between tiotropium-olodaterol and other LAMA/LABA FDCs were not observed for FEV1 or other efficacy markers. Therefore, tiotropium-olodaterol is a valuable option in the treatment of COPD patients who remain symptomatic under monotherapy.
Keywords
COPD, bronchodilatation, dyspnea, exacerbation, exercise tolerance, LABA, LAMA, spirometry, OBSTRUCTIVE PULMONARY-DISEASE, ACLIDINIUM BROMIDE/FORMOTEROL FUMARATE, UMECLIDINIUM/VILANTEROL 62.5/25 MCG, RANDOMIZED CONTROLLED-TRIALS, ONCE-DAILY TIOTROPIUM, LUNG-FUNCTION, DOUBLE-BLIND, EXERCISE TOLERANCE, PLUS OLODATEROL, PHARMACOLOGICAL TRIALS

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Chicago
Derom, Eric, Guy Brusselle, and Guy Joos. 2016. “Efficacy of Tiotropium-olodaterol Fixed-dose Combination in COPD.” International Journal of Chronic Obstructive Pulmonary Disease 11: 3163–3177.
APA
Derom, E., Brusselle, G., & Joos, G. (2016). Efficacy of tiotropium-olodaterol fixed-dose combination in COPD. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 3163–3177.
Vancouver
1.
Derom E, Brusselle G, Joos G. Efficacy of tiotropium-olodaterol fixed-dose combination in COPD. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2016;11:3163–77.
MLA
Derom, Eric, Guy Brusselle, and Guy Joos. “Efficacy of Tiotropium-olodaterol Fixed-dose Combination in COPD.” INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 11 (2016): 3163–3177. Print.
@article{8500411,
  abstract     = {Tiotropium-olodaterol, formulated in the Respimat soft-mist inhaler, is an inhaled fixed-dose combination (FDC) of a long-acting muscarinic antagonist (LAMA) and a long-acting beta(2)-agonist (LABA), commercialized under the name of Spiolto or Stiolto. The efficacy of tiotropium-olodaterol 5-5 mu g once daily in adult patients with COPD was documented in eleven large, multicenter trials of up to 52 weeks duration. Tiotropium-olodaterol 5-5 mu g not only improved spirometric values to a significantly greater extent than placebo but also resulted in statistically significant beneficial effects on dyspnea, markers of hyperinflation, use of rescue medication, health-related quality of life, and exercise endurance. Improvements exceeded the minimal clinically important difference (MCID) for forced expiratory volume in 1 second (FEV1), dyspnea, and quality of life. Differences between tiotropium-olodaterol 5-5 mu g and the respective monocomponents were statistically significant for FEV1, dyspnea, markers of hyperinflation, use of rescue medication, and health-related quality of life, but did not reach the MCID. However, dual bronchodilatation significantly increased the number of patients who exceeded the MCID for dyspnea and quality of life. Moreover, tiotropium-olodaterol 5-5 mu g was significantly more effective than salmeterol-fluticasone (FDC) twice daily at improving pulmonary function. Differences between tiotropium-olodaterol and other LAMA/LABA FDCs were not observed for FEV1 or other efficacy markers. Therefore, tiotropium-olodaterol is a valuable option in the treatment of COPD patients who remain symptomatic under monotherapy.},
  author       = {Derom, Eric and Brusselle, Guy and Joos, Guy},
  issn         = {1178-2005},
  journal      = {INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE},
  keyword      = {COPD,bronchodilatation,dyspnea,exacerbation,exercise tolerance,LABA,LAMA,spirometry,OBSTRUCTIVE PULMONARY-DISEASE,ACLIDINIUM BROMIDE/FORMOTEROL FUMARATE,UMECLIDINIUM/VILANTEROL 62.5/25 MCG,RANDOMIZED CONTROLLED-TRIALS,ONCE-DAILY TIOTROPIUM,LUNG-FUNCTION,DOUBLE-BLIND,EXERCISE TOLERANCE,PLUS OLODATEROL,PHARMACOLOGICAL TRIALS},
  language     = {eng},
  pages        = {3163--3177},
  title        = {Efficacy of tiotropium-olodaterol fixed-dose combination in COPD},
  url          = {http://dx.doi.org/10.2147/copd.s92840},
  volume       = {11},
  year         = {2016},
}

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