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Athlome Project Consortium : a concerted effort to discover genomic and other 'omic' markers of athletic performance

(2016) PHYSIOLOGICAL GENOMICS. 48(3). p.183-190
Author
Organization
Abstract
Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large sample sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14-17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium.
Keywords
Genetics, Physiology, genetics, performance, sports genomics, Exercise Physiology and Nutrition, CONSENT, BIOBANKS, ETHICS

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MLA
Pitsiladis, Yannis P et al. “Athlome Project Consortium : a Concerted Effort to Discover Genomic and Other ‘Omic’ Markers of Athletic Performance.” PHYSIOLOGICAL GENOMICS 48.3 (2016): 183–190. Print.
APA
Pitsiladis, Y. P., Tanaka, M., Eynon, N., Bouchard, C., North, K. N., Williams, A. G., Collins, M., et al. (2016). Athlome Project Consortium : a concerted effort to discover genomic and other “omic” markers of athletic performance. PHYSIOLOGICAL GENOMICS, 48(3), 183–190.
Chicago author-date
Pitsiladis, Yannis P, Masashi Tanaka, Nir Eynon, Claude Bouchard, Kathryn N North, Alun G Williams, Malcolm Collins, et al. 2016. “Athlome Project Consortium : a Concerted Effort to Discover Genomic and Other ‘Omic’ Markers of Athletic Performance.” Physiological Genomics 48 (3): 183–190.
Chicago author-date (all authors)
Pitsiladis, Yannis P, Masashi Tanaka, Nir Eynon, Claude Bouchard, Kathryn N North, Alun G Williams, Malcolm Collins, Colin N Moran, Steven L Britton, Noriyuki Fuku, Euan A Ashley, Vassilis Klissouras, Alejandro Lucia, Ildus I Ahmetov, Eco de Geus, Mohammed Alsayrafi, the Athlome Project Consortium, Wim Derave, and Audrey Baguet. 2016. “Athlome Project Consortium : a Concerted Effort to Discover Genomic and Other ‘Omic’ Markers of Athletic Performance.” Physiological Genomics 48 (3): 183–190.
Vancouver
1.
Pitsiladis YP, Tanaka M, Eynon N, Bouchard C, North KN, Williams AG, et al. Athlome Project Consortium : a concerted effort to discover genomic and other “omic” markers of athletic performance. PHYSIOLOGICAL GENOMICS. 2016;48(3):183–90.
IEEE
[1]
Y. P. Pitsiladis et al., “Athlome Project Consortium : a concerted effort to discover genomic and other ‘omic’ markers of athletic performance,” PHYSIOLOGICAL GENOMICS, vol. 48, no. 3, pp. 183–190, 2016.
@article{8500408,
  abstract     = {Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large sample sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14-17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium.},
  author       = {Pitsiladis, Yannis P and Tanaka, Masashi and Eynon, Nir and Bouchard, Claude and North, Kathryn N and Williams, Alun G and Collins, Malcolm and Moran, Colin N and Britton, Steven L and Fuku, Noriyuki and Ashley, Euan A and Klissouras, Vassilis and Lucia, Alejandro and Ahmetov, Ildus I and de Geus, Eco and Alsayrafi, Mohammed and Athlome Project Consortium, the and Derave, Wim and Baguet, Audrey},
  issn         = {1094-8341},
  journal      = {PHYSIOLOGICAL GENOMICS},
  keywords     = {Genetics,Physiology,genetics,performance,sports genomics,Exercise Physiology and Nutrition,CONSENT,BIOBANKS,ETHICS},
  language     = {eng},
  number       = {3},
  pages        = {183--190},
  title        = {Athlome Project Consortium : a concerted effort to discover genomic and other 'omic' markers of athletic performance},
  url          = {http://dx.doi.org/10.1152/physiolgenomics.00105.2015},
  volume       = {48},
  year         = {2016},
}

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