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Evolution of protein-bound uraemic solutes during predilution haemofiltration

Natalie Meert, Charles Beerenhout, Eva Schepers, Griet Glorieux UGent, Jeroen Kooman and Raymond Vanholder UGent (2009) JOURNAL OF NEPHROLOGY. 22(3). p.352-357
abstract
Background: Protein-bound uraemic toxins provoke multiple biological changes involved in uraemia. Few if any dialytic strategies remove these compounds. Methods: In this post hoc analysis of remnant samples from a randomised controlled trial, we evaluate whether predilution haemofiltration ( HF) decreases the pretreatment concentration of protein-bound uraemic solutes. Patients treated with low-flux haemodialysis ( HD) were enrolled into a group continuing this strategy ( group A, n=8) over 6 months, whereas group B ( n=12) was switched to predilution online HF. Blood was sampled at baseline and after 6 months to determine total and free concentration and percentage binding of indoxyl sulfate ( IS), indole-3-acetic acid ( IAA), hippuric acid ( HA), p-cresol ( PC) and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid ( CMPF). Results: Comparing concentrations at start versus 6 months of treatment by paired analysis, HD had no impact. In contrast, at the end of the HF period, we found a decrease in total and free PC, free IAA and total CMPF. In addition, the percentage protein binding of IAA increased significantly. However, unpaired analysis revealed no statistical difference between HD and HF, both at baseline and after 6 months of treatment for all compounds. Conclusions: Paired analysis showed a beneficial impact of predilution online HF for several protein-bound uraemic solutes. Unpaired analysis, however, showed no statistical difference.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
keyword
FURANCARBOXYLIC ACID, TOXINS, P-CRESOL, CONVECTIVE-TRANSPORT, PERITONEAL-DIALYSIS, EFFICIENT REMOVAL, MIDDLE MOLECULES, HEMODIAFILTRATION, MORTALITY, HEMODIALYSIS
journal title
JOURNAL OF NEPHROLOGY
J. Nephrol.
volume
22
issue
3
pages
6 pages
publisher
WICHTIG EDITORE
place of publication
MILAN
Web of Science type
Article
Web of Science id
000269101200007
JCR category
UROLOGY & NEPHROLOGY
JCR impact factor
1.252 (2009)
JCR rank
44/61 (2009)
JCR quartile
3 (2009)
ISSN
1121-8428
language
English
UGent publication?
yes
classification
A1
id
849695
handle
http://hdl.handle.net/1854/LU-849695
date created
2010-02-02 15:50:01
date last changed
2017-01-02 09:54:46
@article{849695,
  abstract     = {Background: Protein-bound uraemic toxins provoke multiple biological changes involved in uraemia. Few if any dialytic strategies remove these compounds.

Methods: In this post hoc analysis of remnant samples from a randomised controlled trial, we evaluate whether predilution haemofiltration ( HF) decreases the pretreatment concentration of protein-bound uraemic solutes. Patients treated with low-flux haemodialysis ( HD) were enrolled into a group continuing this strategy ( group A, n=8) over 6 months, whereas group B ( n=12) was switched to predilution online HF. Blood was sampled at baseline and after 6 months to determine total and free concentration and percentage binding of indoxyl sulfate ( IS), indole-3-acetic acid ( IAA), hippuric acid ( HA), p-cresol ( PC) and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid ( CMPF).

Results: Comparing concentrations at start versus 6 months of treatment by paired analysis, HD had no impact. In contrast, at the end of the HF period, we found a decrease in total and free PC, free IAA and total CMPF. In addition, the percentage protein binding of IAA increased significantly. However, unpaired analysis revealed no statistical difference between HD and HF, both at baseline and after 6 months of treatment for all compounds.

Conclusions: Paired analysis showed a beneficial impact of predilution online HF for several protein-bound uraemic solutes. Unpaired analysis, however, showed no statistical difference.},
  author       = {Meert, Natalie and Beerenhout, Charles and Schepers, Eva and Glorieux, Griet and Kooman, Jeroen and Vanholder, Raymond},
  issn         = {1121-8428},
  journal      = {JOURNAL OF NEPHROLOGY},
  keyword      = {FURANCARBOXYLIC ACID,TOXINS,P-CRESOL,CONVECTIVE-TRANSPORT,PERITONEAL-DIALYSIS,EFFICIENT REMOVAL,MIDDLE MOLECULES,HEMODIAFILTRATION,MORTALITY,HEMODIALYSIS},
  language     = {eng},
  number       = {3},
  pages        = {352--357},
  publisher    = {WICHTIG EDITORE},
  title        = {Evolution of protein-bound uraemic solutes during predilution haemofiltration},
  volume       = {22},
  year         = {2009},
}

Chicago
Meert, Natalie, Charles Beerenhout, Eva Schepers, Griet Glorieux, Jeroen Kooman, and Raymond Vanholder. 2009. “Evolution of Protein-bound Uraemic Solutes During Predilution Haemofiltration.” Journal of Nephrology 22 (3): 352–357.
APA
Meert, N., Beerenhout, C., Schepers, E., Glorieux, G., Kooman, J., & Vanholder, R. (2009). Evolution of protein-bound uraemic solutes during predilution haemofiltration. JOURNAL OF NEPHROLOGY, 22(3), 352–357.
Vancouver
1.
Meert N, Beerenhout C, Schepers E, Glorieux G, Kooman J, Vanholder R. Evolution of protein-bound uraemic solutes during predilution haemofiltration. JOURNAL OF NEPHROLOGY. MILAN: WICHTIG EDITORE; 2009;22(3):352–7.
MLA
Meert, Natalie, Charles Beerenhout, Eva Schepers, et al. “Evolution of Protein-bound Uraemic Solutes During Predilution Haemofiltration.” JOURNAL OF NEPHROLOGY 22.3 (2009): 352–357. Print.