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Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis

(2010) JOURNAL OF UROLOGY. 183(1). p.297-301
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Abstract
Purpose: We evaluated the incidence of hypercalciuria, defined as urinary calcium-to-creatinine ratio greater than 0.21 mg/mg, in children with nocturnal enuresis, and the association with concurrent values of diuresis and osmolar excretion. Materials and Methods: A total of 550 children admitted to a tertiary university center were included in the study. A 24-hour urine collection was performed in 8 sampling periods for measurement of calcium excretion, osmolality and diuresis. Results: Of the children with nocturnal enuresis 12% had 24-hour hypercalciuria. Up to 29% of the timed urine samples exhibited hypercalciuria. There was a significant correlation between calcium excretion and nocturnal diuresis volume (polyuria), low urinary osmolality, and increased sodium and osmolar excretion of nighttime urine samples (all p < 0.001). Conclusions: Patients referred to a tertiary enuresis center have a high incidence of hypercalciuria. However, the significant correlation between hypercalciuria and osmolar excretion and diuresis suggests that it is a comorbid factor rather than a primary pathogenic factor. As such, we cannot confirm the data from Italian studies relating nocturnal enuresis to primary hypercalciuria, and suggest instead an association with nutritional intake.
Keywords
VASOPRESSIN, HEALTHY-CHILDREN, POLYURIA, hypercalciuria, deamino arginine vasopressin, polyuria, kidney concentrating ability, nocturnal enuresis, CIRCADIAN-RHYTHM, ENURETIC CHILDREN, PATHOGENESIS

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MLA
Raes, Ann et al. “Hypercalciuria Is Related to Osmolar Excretion in Children with Nocturnal Enuresis.” JOURNAL OF UROLOGY 183.1 (2010): 297–301. Print.
APA
Raes, Ann, Dossche, L., Hertegonne, N., Nuytemans, L., Hoebeke, P., Van Laecke, E., Donckerwolcke, R. A., et al. (2010). Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis. JOURNAL OF UROLOGY, 183(1), 297–301.
Chicago author-date
Raes, Ann, Lien Dossche, Nele Hertegonne, Laure Nuytemans, Piet Hoebeke, Erik Van Laecke, Raymond AMG Donckerwolcke, and Johan Vande Walle. 2010. “Hypercalciuria Is Related to Osmolar Excretion in Children with Nocturnal Enuresis.” Journal of Urology 183 (1): 297–301.
Chicago author-date (all authors)
Raes, Ann, Lien Dossche, Nele Hertegonne, Laure Nuytemans, Piet Hoebeke, Erik Van Laecke, Raymond AMG Donckerwolcke, and Johan Vande Walle. 2010. “Hypercalciuria Is Related to Osmolar Excretion in Children with Nocturnal Enuresis.” Journal of Urology 183 (1): 297–301.
Vancouver
1.
Raes A, Dossche L, Hertegonne N, Nuytemans L, Hoebeke P, Van Laecke E, et al. Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis. JOURNAL OF UROLOGY. 2010;183(1):297–301.
IEEE
[1]
A. Raes et al., “Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis,” JOURNAL OF UROLOGY, vol. 183, no. 1, pp. 297–301, 2010.
@article{848184,
  abstract     = {Purpose: We evaluated the incidence of hypercalciuria, defined as urinary calcium-to-creatinine ratio greater than 0.21 mg/mg, in children with nocturnal enuresis, and the association with concurrent values of diuresis and osmolar excretion.
Materials and Methods: A total of 550 children admitted to a tertiary university center were included in the study. A 24-hour urine collection was performed in 8 sampling periods for measurement of calcium excretion, osmolality and diuresis.
Results: Of the children with nocturnal enuresis 12% had 24-hour hypercalciuria. Up to 29% of the timed urine samples exhibited hypercalciuria. There was a significant correlation between calcium excretion and nocturnal diuresis volume (polyuria), low urinary osmolality, and increased sodium and osmolar excretion of nighttime urine samples (all p < 0.001).
Conclusions: Patients referred to a tertiary enuresis center have a high incidence of hypercalciuria. However, the significant correlation between hypercalciuria and osmolar excretion and diuresis suggests that it is a comorbid factor rather than a primary pathogenic factor. As such, we cannot confirm the data from Italian studies relating nocturnal enuresis to primary hypercalciuria, and suggest instead an association with nutritional intake.},
  author       = {Raes, Ann and Dossche, Lien and Hertegonne, Nele and Nuytemans, Laure and Hoebeke, Piet and Van Laecke, Erik and Donckerwolcke, Raymond AMG and Vande Walle, Johan},
  issn         = {0022-5347},
  journal      = {JOURNAL OF UROLOGY},
  keywords     = {VASOPRESSIN,HEALTHY-CHILDREN,POLYURIA,hypercalciuria,deamino arginine vasopressin,polyuria,kidney concentrating ability,nocturnal enuresis,CIRCADIAN-RHYTHM,ENURETIC CHILDREN,PATHOGENESIS},
  language     = {eng},
  number       = {1},
  pages        = {297--301},
  title        = {Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis},
  url          = {http://dx.doi.org/10.1016/j.juro.2009.08.175},
  volume       = {183},
  year         = {2010},
}

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