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A globin in the nucleus!

Eva Geuens, Inge Brouns, Daisy Flamez UGent, Sylvia Dewilde, Jean-Pierre Timmermans and Luc Moens (2003) JOURNAL OF BIOLOGICAL CHEMISTRY. 278(33). p.30417-30420
abstract
Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues. In the present study, polyclonal antibodies were raised against both proteins and the distribution of them was studied by immunocytochemistry at tissue and subcellular level. Cytoglobin immunoreactivity was uniformly distributed and found in all tissues studied. At the subcellular level, cytoglobin immunoreactivity was exclusively detected in the cell nucleus. In contrast, neuroglobin immunoreactivity was detected in specific brain regions with varying intensities and in the islet of Langerhans in the pancreas. The immunoreactivity was restricted to the cytoplasm of neurons and endocrine beta cells. The nuclear localization of cytoglobin opens new perspectives for possible function(s) of globin-folded proteins as transcriptional regulators.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
LIGAND-BINDING PROPERTIES, ACTIVATION-ASSOCIATED PROTEIN, HEME-BASED SENSORS, NONVERTEBRATE HEMOGLOBINS, HEXACOORDINATE HEMOGLOBIN, TRANSCRIPTION FACTOR, OXYGEN SENSOR, DNA-BINDING, NEUROGLOBIN, LOCALIZATION
journal title
JOURNAL OF BIOLOGICAL CHEMISTRY
J. Biol. Chem.
volume
278
issue
33
pages
30417 - 30420
Web of Science type
Article
Web of Science id
000184658800002
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
6.482 (2003)
JCR rank
31/261 (2003)
JCR quartile
1 (2003)
ISSN
0021-9258
DOI
10.1074/jbc.C300203200
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
847267
handle
http://hdl.handle.net/1854/LU-847267
date created
2010-02-01 10:42:12
date last changed
2010-02-08 12:53:05
@article{847267,
  abstract     = {Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues. In the present study, polyclonal antibodies were raised against both proteins and the distribution of them was studied by immunocytochemistry at tissue and subcellular level. Cytoglobin immunoreactivity was uniformly distributed and found in all tissues studied. At the subcellular level, cytoglobin immunoreactivity was exclusively detected in the cell nucleus. In contrast, neuroglobin immunoreactivity was detected in specific brain regions with varying intensities and in the islet of Langerhans in the pancreas. The immunoreactivity was restricted to the cytoplasm of neurons and endocrine beta cells. The nuclear localization of cytoglobin opens new perspectives for possible function(s) of globin-folded proteins as transcriptional regulators.},
  author       = {Geuens, Eva and Brouns, Inge and Flamez, Daisy and Dewilde, Sylvia and Timmermans, Jean-Pierre and Moens, Luc},
  issn         = {0021-9258},
  journal      = {JOURNAL OF BIOLOGICAL CHEMISTRY},
  keyword      = {LIGAND-BINDING PROPERTIES,ACTIVATION-ASSOCIATED PROTEIN,HEME-BASED SENSORS,NONVERTEBRATE HEMOGLOBINS,HEXACOORDINATE HEMOGLOBIN,TRANSCRIPTION FACTOR,OXYGEN SENSOR,DNA-BINDING,NEUROGLOBIN,LOCALIZATION},
  language     = {eng},
  number       = {33},
  pages        = {30417--30420},
  title        = {A globin in the nucleus!},
  url          = {http://dx.doi.org/10.1074/jbc.C300203200},
  volume       = {278},
  year         = {2003},
}

Chicago
Geuens, Eva, Inge Brouns, Daisy Flamez, Sylvia Dewilde, Jean-Pierre Timmermans, and Luc Moens. 2003. “A Globin in the Nucleus!” Journal of Biological Chemistry 278 (33): 30417–30420.
APA
Geuens, E., Brouns, I., Flamez, D., Dewilde, S., Timmermans, J.-P., & Moens, L. (2003). A globin in the nucleus! JOURNAL OF BIOLOGICAL CHEMISTRY, 278(33), 30417–30420.
Vancouver
1.
Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans J-P, Moens L. A globin in the nucleus! JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(33):30417–20.
MLA
Geuens, Eva, Inge Brouns, Daisy Flamez, et al. “A Globin in the Nucleus!” JOURNAL OF BIOLOGICAL CHEMISTRY 278.33 (2003): 30417–30420. Print.