Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes
- Author
- Décio L Eizirik, Fabrice Moore, Daisy Flamez (UGent) and Fernanda Ortis
- Organization
- Abstract
- Accumulating evidence indicates that p-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that p-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcription factors such as NF-kappa B (nuclear factor kappa B) and STAT-1 (signal transducer and activator of transcription 1). Understanding the regulation of these gene networks, and how they modulate P-cell death and the 'dialogue' between beta-cells and the immune system, will require a systems biology approach to the problem. This will hopefully allow the search for a cure for T1DM to move from a 'trial-and-error' approach to one that is really mechanistically driven.
- Keywords
- INDUCED APOPTOSIS, SIGNAL TRANSDUCER, GENE-TRANSFER, NOD MICE, ISLET TRANSPLANTATION, INSULIN-PRODUCING CELLS, ENDOPLASMIC-RETICULUM STRESS, DOUBLE-STRANDED-RNA, pancreatic beta-cell, systems biology, NF-KAPPA-B, endoplasmic reticulum stress, diabetes mellitus, apoptosis, cytokine, INTERFERON-GAMMA
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-847042
- Chicago
- Eizirik, Décio L, Fabrice Moore, Daisy Flamez, and Fernanda Ortis. 2008. “Use of a Systems Biology Approach to Understand Pancreatic Beta-cell Death in Type 1 Diabetes.” Biochemical Society Transactions 36 (3): 321–327.
- APA
- Eizirik, D. L., Moore, F., Flamez, D., & Ortis, F. (2008). Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. BIOCHEMICAL SOCIETY TRANSACTIONS, 36(3), 321–327. Presented at the Biochemical-Society-Irish-Area-Section Annual Meeting on Ubiquitin and Ubiquitin-Like Modification in Health and Disease.
- Vancouver
- 1.Eizirik DL, Moore F, Flamez D, Ortis F. Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. BIOCHEMICAL SOCIETY TRANSACTIONS. 2008;36(3):321–7.
- MLA
- Eizirik, Décio L et al. “Use of a Systems Biology Approach to Understand Pancreatic Beta-cell Death in Type 1 Diabetes.” BIOCHEMICAL SOCIETY TRANSACTIONS 36.3 (2008): 321–327. Print.
@article{847042,
abstract = {Accumulating evidence indicates that p-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that p-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcription factors such as NF-kappa B (nuclear factor kappa B) and STAT-1 (signal transducer and activator of transcription 1). Understanding the regulation of these gene networks, and how they modulate P-cell death and the 'dialogue' between beta-cells and the immune system, will require a systems biology approach to the problem. This will hopefully allow the search for a cure for T1DM to move from a 'trial-and-error' approach to one that is really mechanistically driven.},
author = {Eizirik, Décio L and Moore, Fabrice and Flamez, Daisy and Ortis, Fernanda},
issn = {0300-5127},
journal = {BIOCHEMICAL SOCIETY TRANSACTIONS},
keywords = {INDUCED APOPTOSIS,SIGNAL TRANSDUCER,GENE-TRANSFER,NOD MICE,ISLET TRANSPLANTATION,INSULIN-PRODUCING CELLS,ENDOPLASMIC-RETICULUM STRESS,DOUBLE-STRANDED-RNA,pancreatic beta-cell,systems biology,NF-KAPPA-B,endoplasmic reticulum stress,diabetes mellitus,apoptosis,cytokine,INTERFERON-GAMMA},
language = {eng},
location = {Dublin, Ireland},
number = {3},
pages = {321--327},
title = {Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes},
url = {http://dx.doi.org/10.1042/BST0360321},
volume = {36},
year = {2008},
}
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