Advanced search
1 file | 416.83 KB

The reservoir pressure concept: the 3-element windkessel model revisited?: application to the Asklepios population study

SEBASTIAN VERMEERSCH (UGent) , Ernst Rietzschel (UGent) , Marc De Buyzere (UGent) , Lucas Van Bortel (UGent) , Thierry Gillebert (UGent) , Pascal Verdonck (UGent) and Patrick Segers (UGent)
Author
Organization
Abstract
Traditionally the arterial system is either modeled as a lumped-parameter windkessel or a wave system. Recently, a hybrid model has been proposed in which the arterial system is considered to be a reservoir allowing for superimposed wave phenomena. This approach was applied to non-invasively obtained carotid pressure waveforms from 2019 subjects from the Asklepios population to investigate the contribution of reservoir pressure (PP (res,WS)) to carotid pulse pressure (PP (car)) with age and gender. Additionally, reservoir pressures were compared to the reservoir pressure (PP (res,WK)) obtained from a 3-element windkessel model. PP (res,WK) and PP (res,WS) were determined by applying a 3-element windkessel model and the wave separation model to scaled carotid artery tonometry readings. The evolution of PP (car), PP (res,WK) and PP (res,WS) was examined for men and women after stratification into age quartiles. PP (car) increased with age regardless of sex, but was more pronounced in women, with significant (P < 0.001) age-gender interaction. PP (res) increases with age (P < 0.001), regardless of the model used for its determination, but more significantly for women. In men it only increases markedly in the oldest age group. Overall, the reservoir pressure concept showed large similarities to the classical 3-element windkessel model, especially in subjects characterized by a high reflection magnitude and high "windkesselness" of their arterial system. When applied to the Asklepios population, both models show the increase of pulse pressure with age to be largely due to increasing reservoir pressures.
Keywords
Arterial system, Arterial stiffness, Hemodynamics, Modeling, Pulse pressure, Wave reflection, SYSTEMIC ARTERIAL TREE, NONINVASIVE ASSESSMENT, PULSE PRESSURE, BLOOD-PRESSURE, HEALTHY, WAVES, TONOMETRY, VELOCITY, DESIGN, FLOW

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 416.83 KB

Citation

Please use this url to cite or link to this publication:

Chicago
VERMEERSCH, SEBASTIAN, Ernst Rietzschel, MARC DE BUYZERE, Lucas Van Bortel, Thierry Gillebert, Pascal Verdonck, and Patrick Segers. 2009. “The Reservoir Pressure Concept: The 3-element Windkessel Model Revisited?: Application to the Asklepios Population Study.” Journal of Engineering Mathematics 64 (4): 417–428.
APA
VERMEERSCH, SEBASTIAN, Rietzschel, E., DE BUYZERE, M., Van Bortel, L., Gillebert, T., Verdonck, P., & Segers, P. (2009). The reservoir pressure concept: the 3-element windkessel model revisited?: application to the Asklepios population study. JOURNAL OF ENGINEERING MATHEMATICS, 64(4), 417–428.
Vancouver
1.
VERMEERSCH S, Rietzschel E, DE BUYZERE M, Van Bortel L, Gillebert T, Verdonck P, et al. The reservoir pressure concept: the 3-element windkessel model revisited?: application to the Asklepios population study. JOURNAL OF ENGINEERING MATHEMATICS. 2009;64(4):417–28.
MLA
VERMEERSCH, SEBASTIAN, Ernst Rietzschel, MARC DE BUYZERE, et al. “The Reservoir Pressure Concept: The 3-element Windkessel Model Revisited?: Application to the Asklepios Population Study.” JOURNAL OF ENGINEERING MATHEMATICS 64.4 (2009): 417–428. Print.
@article{846332,
  abstract     = {Traditionally the arterial system is either modeled as a lumped-parameter windkessel or a wave system. Recently, a hybrid model has been proposed in which the arterial system is considered to be a reservoir allowing for superimposed wave phenomena. This approach was applied to non-invasively obtained carotid pressure waveforms from 2019 subjects from the Asklepios population to investigate the contribution of reservoir pressure (PP (res,WS)) to carotid pulse pressure (PP (car)) with age and gender. Additionally, reservoir pressures were compared to the reservoir pressure (PP (res,WK)) obtained from a 3-element windkessel model. PP (res,WK) and PP (res,WS) were determined by applying a 3-element windkessel model and the wave separation model to scaled carotid artery tonometry readings. The evolution of PP (car), PP (res,WK) and PP (res,WS) was examined for men and women after stratification into age quartiles. PP (car) increased with age regardless of sex, but was more pronounced in women, with significant (P {\textlangle} 0.001) age-gender interaction. PP (res) increases with age (P {\textlangle}  0.001), regardless of the model used for its determination, but more significantly for women. In men it only increases markedly in the oldest age group. Overall, the reservoir pressure concept showed large similarities to the classical 3-element windkessel model, especially in subjects characterized by a high reflection magnitude and high {\textacutedbl}windkesselness{\textacutedbl} of their arterial system. When applied to the Asklepios population, both models show the increase of pulse pressure with age to be largely due to increasing reservoir pressures.},
  author       = {VERMEERSCH, SEBASTIAN and Rietzschel, Ernst and De Buyzere, Marc and Van Bortel, Lucas and Gillebert, Thierry and Verdonck, Pascal and Segers, Patrick},
  issn         = {0022-0833},
  journal      = {JOURNAL OF ENGINEERING MATHEMATICS},
  keyword      = {Arterial system,Arterial stiffness,Hemodynamics,Modeling,Pulse pressure,Wave reflection,SYSTEMIC ARTERIAL TREE,NONINVASIVE ASSESSMENT,PULSE PRESSURE,BLOOD-PRESSURE,HEALTHY,WAVES,TONOMETRY,VELOCITY,DESIGN,FLOW},
  language     = {eng},
  number       = {4},
  pages        = {417--428},
  title        = {The reservoir pressure concept: the 3-element windkessel model revisited?: application to the Asklepios population study},
  url          = {http://dx.doi.org/10.1007/s10665-009-9286-y},
  volume       = {64},
  year         = {2009},
}

Altmetric
View in Altmetric
Web of Science
Times cited: