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HCV animal models : a journey of more than 30 years

Philip Meuleman (UGent) and Geert Leroux-Roels (UGent)
(2009) VIRUSES-BASEL. 1(2). p.222-240
Author
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Abstract
In the 1970s and 1980s it became increasingly clear that blood transfusions could induce a form of chronic hepatitis that could not be ascribed to any of the viruses known to cause liver inflammation. In 1989, the hepatitis C virus (HCV) was discovered and found to be the major causative agent of these infections. Because of its narrow tropism, the in vivo study of this virus was, especially in the early days, limited to the chimpanzee. In the past decade, several alternative animal models have been created. In this review we review these novel animal models and their contribution to our current understanding of the biology of HCV.
Keywords
NON-A-HEPATITIS, CHIMERIC HUMAN LIVERS, UPA-SCID MOUSE, TRANSGENIC MICE, CELL-CULTURE, HEPATOCELLULAR-CARCINOMA, HCV, animal model, chimpanzee, chimeric mice, uPA-SCID, hepatitis C, antiviral therapy, neutralizing antibodies, HEPATITIS-C-VIRUS, NON-B-HEPATITIS, INFECTIOUS IN-VIVO, PLASMINOGEN-ACTIVATOR MOUSE

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Citation

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MLA
Meuleman, Philip, and Geert Leroux-Roels. “HCV Animal Models : A Journey of More than 30 Years.” VIRUSES-BASEL, vol. 1, no. 2, 2009, pp. 222–40, doi:10.3390/v1020222.
APA
Meuleman, P., & Leroux-Roels, G. (2009). HCV animal models : a journey of more than 30 years. VIRUSES-BASEL, 1(2), 222–240. https://doi.org/10.3390/v1020222
Chicago author-date
Meuleman, Philip, and Geert Leroux-Roels. 2009. “HCV Animal Models : A Journey of More than 30 Years.” VIRUSES-BASEL 1 (2): 222–40. https://doi.org/10.3390/v1020222.
Chicago author-date (all authors)
Meuleman, Philip, and Geert Leroux-Roels. 2009. “HCV Animal Models : A Journey of More than 30 Years.” VIRUSES-BASEL 1 (2): 222–240. doi:10.3390/v1020222.
Vancouver
1.
Meuleman P, Leroux-Roels G. HCV animal models : a journey of more than 30 years. VIRUSES-BASEL. 2009;1(2):222–40.
IEEE
[1]
P. Meuleman and G. Leroux-Roels, “HCV animal models : a journey of more than 30 years,” VIRUSES-BASEL, vol. 1, no. 2, pp. 222–240, 2009.
@article{843335,
  abstract     = {{In the 1970s and 1980s it became increasingly clear that blood transfusions could induce a form of chronic hepatitis that could not be ascribed to any of the viruses known to cause liver inflammation. In 1989, the hepatitis C virus (HCV) was discovered and found to be the major causative agent of these infections. Because of its narrow tropism, the in vivo study of this virus was, especially in the early days, limited to the chimpanzee. In the past decade, several alternative animal models have been created. In this review we review these novel animal models and their contribution to our current understanding of the biology of HCV.}},
  author       = {{Meuleman, Philip and Leroux-Roels, Geert}},
  issn         = {{1999-4915}},
  journal      = {{VIRUSES-BASEL}},
  keywords     = {{NON-A-HEPATITIS,CHIMERIC HUMAN LIVERS,UPA-SCID MOUSE,TRANSGENIC MICE,CELL-CULTURE,HEPATOCELLULAR-CARCINOMA,HCV,animal model,chimpanzee,chimeric mice,uPA-SCID,hepatitis C,antiviral therapy,neutralizing antibodies,HEPATITIS-C-VIRUS,NON-B-HEPATITIS,INFECTIOUS IN-VIVO,PLASMINOGEN-ACTIVATOR MOUSE}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{222--240}},
  title        = {{HCV animal models : a journey of more than 30 years}},
  url          = {{http://doi.org/10.3390/v1020222}},
  volume       = {{1}},
  year         = {{2009}},
}
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