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Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT

Simon Vermeire (UGent) , Kurt Audenaert (UGent) , André Dobbeleir, Rudy De Meester (UGent) , Eva Vandermeulen (UGent) , Tim Waelbers (UGent) and Kathelijne Peremans (UGent)
(2009) BRAIN IMAGING AND BEHAVIOR. 3(4). p.342-349
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Abstract
Alterations of regional brain activity in the prefrontal cortex and in limbic areas have been reported in humans with anxiety disorders. This animal study reports the results of brain perfusion imaging with single photon emission computed tomography (SPECT) in dogs with anxiety disorders. Based on the human literature, we hypothesized altered prefrontal and higher temporal brain perfusion. SPECT acquisitions were performed using the Tc-99m-labelled tracer ethyl cysteinate dimer (ECD). Eighteen dogs with pathological anxiety were compared with 18 normally behaving reference dogs. We found, in the group of dogs with anxiety disorders, lower perfusion in the left frontal cortex (p = 0.003), in the subcortical region (p = 0.007) and increased perfusion in the right (p = 0.05) temporal cortex. Taken together, our rCBF findings are suggestive for a dysfunction of the prefrontal cortex and the limbic system in canine anxiety disorders.
Keywords
PHOTON-EMISSION-TOMOGRAPHY, Dog, rCBF, Brain perfusion, SPECT, Anxiety disorders, SCHIZOPHRENIA, PTSD, SOCIAL PHOBIA, HEALTHY CONTROLS, RECEPTOR-BINDING, PANIC DISORDER, BRAIN PERFUSION, POSTTRAUMATIC-STRESS-DISORDER, MEDIAL PREFRONTAL CORTEX

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MLA
Vermeire, Simon et al. “Regional Cerebral Blood Flow Changes in Dogs with Anxiety Disorders, Measured with SPECT.” BRAIN IMAGING AND BEHAVIOR 3.4 (2009): 342–349. Print.
APA
Vermeire, Simon, Audenaert, K., Dobbeleir, A., De Meester, R., Vandermeulen, E., Waelbers, T., & Peremans, K. (2009). Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT. BRAIN IMAGING AND BEHAVIOR, 3(4), 342–349.
Chicago author-date
Vermeire, Simon, Kurt Audenaert, André Dobbeleir, Rudy De Meester, Eva Vandermeulen, Tim Waelbers, and Kathelijne Peremans. 2009. “Regional Cerebral Blood Flow Changes in Dogs with Anxiety Disorders, Measured with SPECT.” Brain Imaging and Behavior 3 (4): 342–349.
Chicago author-date (all authors)
Vermeire, Simon, Kurt Audenaert, André Dobbeleir, Rudy De Meester, Eva Vandermeulen, Tim Waelbers, and Kathelijne Peremans. 2009. “Regional Cerebral Blood Flow Changes in Dogs with Anxiety Disorders, Measured with SPECT.” Brain Imaging and Behavior 3 (4): 342–349.
Vancouver
1.
Vermeire S, Audenaert K, Dobbeleir A, De Meester R, Vandermeulen E, Waelbers T, et al. Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT. BRAIN IMAGING AND BEHAVIOR. 2009;3(4):342–9.
IEEE
[1]
S. Vermeire et al., “Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT,” BRAIN IMAGING AND BEHAVIOR, vol. 3, no. 4, pp. 342–349, 2009.
@article{838651,
  abstract     = {Alterations of regional brain activity in the prefrontal cortex and in limbic areas have been reported in humans with anxiety disorders. This animal study reports the results of brain perfusion imaging with single photon emission computed tomography (SPECT) in dogs with anxiety disorders. Based on the human literature, we hypothesized altered prefrontal and higher temporal brain perfusion. SPECT acquisitions were performed using the Tc-99m-labelled tracer ethyl cysteinate dimer (ECD). Eighteen dogs with pathological anxiety were compared with 18 normally behaving reference dogs. We found, in the group of dogs with anxiety disorders, lower perfusion in the left frontal cortex (p = 0.003), in the subcortical region (p = 0.007) and increased perfusion in the right (p = 0.05) temporal cortex. Taken together, our rCBF findings are suggestive for a dysfunction of the prefrontal cortex and the limbic system in canine anxiety disorders.},
  author       = {Vermeire, Simon and Audenaert, Kurt and Dobbeleir, André and De Meester, Rudy and Vandermeulen, Eva and Waelbers, Tim and Peremans, Kathelijne},
  issn         = {1931-7557},
  journal      = {BRAIN IMAGING AND BEHAVIOR},
  keywords     = {PHOTON-EMISSION-TOMOGRAPHY,Dog,rCBF,Brain perfusion,SPECT,Anxiety disorders,SCHIZOPHRENIA,PTSD,SOCIAL PHOBIA,HEALTHY CONTROLS,RECEPTOR-BINDING,PANIC DISORDER,BRAIN PERFUSION,POSTTRAUMATIC-STRESS-DISORDER,MEDIAL PREFRONTAL CORTEX},
  language     = {eng},
  number       = {4},
  pages        = {342--349},
  title        = {Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT},
  url          = {http://dx.doi.org/10.1007/s11682-009-9076-1},
  volume       = {3},
  year         = {2009},
}
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