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Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT

Simon Vermeire UGent, Kurt Audenaert UGent, André Dobbeleir, Rudy De Meester UGent, Eva Vandermeulen UGent, Tim Waelbers UGent and Kathelijne Peremans UGent (2009) BRAIN IMAGING AND BEHAVIOR. 3(4). p.342-349
abstract
Alterations of regional brain activity in the prefrontal cortex and in limbic areas have been reported in humans with anxiety disorders. This animal study reports the results of brain perfusion imaging with single photon emission computed tomography (SPECT) in dogs with anxiety disorders. Based on the human literature, we hypothesized altered prefrontal and higher temporal brain perfusion. SPECT acquisitions were performed using the Tc-99m-labelled tracer ethyl cysteinate dimer (ECD). Eighteen dogs with pathological anxiety were compared with 18 normally behaving reference dogs. We found, in the group of dogs with anxiety disorders, lower perfusion in the left frontal cortex (p = 0.003), in the subcortical region (p = 0.007) and increased perfusion in the right (p = 0.05) temporal cortex. Taken together, our rCBF findings are suggestive for a dysfunction of the prefrontal cortex and the limbic system in canine anxiety disorders.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Dog, PHOTON-EMISSION-TOMOGRAPHY, rCBF, Brain perfusion, SPECT, Anxiety disorders, SCHIZOPHRENIA, PTSD, SOCIAL PHOBIA, HEALTHY CONTROLS, RECEPTOR-BINDING, PANIC DISORDER, BRAIN PERFUSION, POSTTRAUMATIC-STRESS-DISORDER, MEDIAL PREFRONTAL CORTEX
journal title
BRAIN IMAGING AND BEHAVIOR
Brain Imaging Behav.
volume
3
issue
4
pages
342 - 349
Web of Science type
Article
Web of Science id
000272173700004
JCR category
NEUROIMAGING
JCR impact factor
1.044 (2009)
JCR rank
11/13 (2009)
JCR quartile
4 (2009)
ISSN
1931-7557
DOI
10.1007/s11682-009-9076-1
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
838651
handle
http://hdl.handle.net/1854/LU-838651
date created
2010-01-26 10:16:31
date last changed
2011-05-09 13:02:13
@article{838651,
  abstract     = {Alterations of regional brain activity in the prefrontal cortex and in limbic areas have been reported in humans with anxiety disorders. This animal study reports the results of brain perfusion imaging with single photon emission computed tomography (SPECT) in dogs with anxiety disorders. Based on the human literature, we hypothesized altered prefrontal and higher temporal brain perfusion. SPECT acquisitions were performed using the Tc-99m-labelled tracer ethyl cysteinate dimer (ECD). Eighteen dogs with pathological anxiety were compared with 18 normally behaving reference dogs. We found, in the group of dogs with anxiety disorders, lower perfusion in the left frontal cortex (p = 0.003), in the subcortical region (p = 0.007) and increased perfusion in the right (p = 0.05) temporal cortex. Taken together, our rCBF findings are suggestive for a dysfunction of the prefrontal cortex and the limbic system in canine anxiety disorders.},
  author       = {Vermeire, Simon and Audenaert, Kurt and Dobbeleir, Andr{\'e} and De Meester, Rudy and Vandermeulen, Eva and Waelbers, Tim and Peremans, Kathelijne},
  issn         = {1931-7557},
  journal      = {BRAIN IMAGING AND BEHAVIOR},
  keyword      = {Dog,PHOTON-EMISSION-TOMOGRAPHY,rCBF,Brain perfusion,SPECT,Anxiety disorders,SCHIZOPHRENIA,PTSD,SOCIAL PHOBIA,HEALTHY CONTROLS,RECEPTOR-BINDING,PANIC DISORDER,BRAIN PERFUSION,POSTTRAUMATIC-STRESS-DISORDER,MEDIAL PREFRONTAL CORTEX},
  language     = {eng},
  number       = {4},
  pages        = {342--349},
  title        = {Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT},
  url          = {http://dx.doi.org/10.1007/s11682-009-9076-1},
  volume       = {3},
  year         = {2009},
}

Chicago
Vermeire, Simon, Kurt Audenaert, André Dobbeleir, Rudy De Meester, Eva Vandermeulen, Tim Waelbers, and Kathelijne Peremans. 2009. “Regional Cerebral Blood Flow Changes in Dogs with Anxiety Disorders, Measured with SPECT.” Brain Imaging and Behavior 3 (4): 342–349.
APA
Vermeire, Simon, Audenaert, K., Dobbeleir, A., De Meester, R., Vandermeulen, E., Waelbers, T., & Peremans, K. (2009). Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT. BRAIN IMAGING AND BEHAVIOR, 3(4), 342–349.
Vancouver
1.
Vermeire S, Audenaert K, Dobbeleir A, De Meester R, Vandermeulen E, Waelbers T, et al. Regional cerebral blood flow changes in dogs with anxiety disorders, measured with SPECT. BRAIN IMAGING AND BEHAVIOR. 2009;3(4):342–9.
MLA
Vermeire, Simon, Kurt Audenaert, André Dobbeleir, et al. “Regional Cerebral Blood Flow Changes in Dogs with Anxiety Disorders, Measured with SPECT.” BRAIN IMAGING AND BEHAVIOR 3.4 (2009): 342–349. Print.