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Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder

Christien GW de Jong, Séverine Van De Voorde UGent, Herbert Roeyers UGent, Ruth Raymaekers UGent, Albert J Allen, Simone Knijff, HELENE VERHELST UGent, Alfons H Temmink, Leo ME Smit and Rob Rodriques-Pereira, et al. (2009) JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 19(6). p.699-707
abstract
Objective: The effects of a promising pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), atomoxetine, were studied on executive functions in both ADHD and reading disorder (RD) because earlier research demonstrated an overlap in executive functioning deficits in both disorders. In addition, the effects of atomoxetine were explored on lexical decision. Methods: Sixteen children with ADHD, 20 children with ADHD + RD, 21 children with RD, and 26 normal controls were enrolled in a randomized placebo-controlled crossover study. Children were measured on visuospatial working memory, inhibition, and lexical decision on the day of randomization and following two 28-day medication periods. Results: Children with ADHD + RD showed improved visuospatial working memory performance and, to a lesser extent, improved inhibition following atomoxetine treatment compared to placebo. No differential effects of atomoxetine were found for lexical decision in comparison to placebo. In addition, no effects of atomoxetine were demonstrated in the ADHD and RD groups. Conclusion: Atomoxetine improved visuospatial working memory and to a lesser degree inhibition in children with ADHD + RD, which suggests differential developmental pathways for co-morbid ADHD + RD as compared to ADHD and RD alone.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RESPONSE-INHIBITION, DISABILITY, DEFICIT HYPERACTIVITY DISORDER, WORKING-MEMORY, CHILDREN, PERFORMANCE, METAANALYSIS, ADULTS, EFFICACY, TASK
journal title
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
J. Child Adolesc. Psychopharmacol.
volume
19
issue
6
pages
9 pages
Web of Science type
Article
Web of Science id
000273053600011
JCR category
PEDIATRICS
JCR impact factor
2.59 (2009)
JCR rank
15/94 (2009)
JCR quartile
1 (2009)
ISSN
1044-5463
DOI
10.1089/cap.2009.0029
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
837750
handle
http://hdl.handle.net/1854/LU-837750
date created
2010-01-25 17:13:11
date last changed
2010-02-01 11:52:58
@article{837750,
  abstract     = {Objective: The effects of a promising pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), atomoxetine, were studied on executive functions in both ADHD and reading disorder (RD) because earlier research demonstrated an overlap in executive functioning deficits in both disorders. In addition, the effects of atomoxetine were explored on lexical decision.
Methods: Sixteen children with ADHD, 20 children with ADHD + RD, 21 children with RD, and 26 normal controls were enrolled in a randomized placebo-controlled crossover study. Children were measured on visuospatial working memory, inhibition, and lexical decision on the day of randomization and following two 28-day medication periods.
Results: Children with ADHD + RD showed improved visuospatial working memory performance and, to a lesser extent, improved inhibition following atomoxetine treatment compared to placebo. No differential effects of atomoxetine were found for lexical decision in comparison to placebo. In addition, no effects of atomoxetine were demonstrated in the ADHD and RD groups.
Conclusion: Atomoxetine improved visuospatial working memory and to a lesser degree inhibition in children with ADHD + RD, which suggests differential developmental pathways for co-morbid ADHD + RD as compared to ADHD and RD alone.},
  author       = {de Jong, Christien GW and Van De Voorde, S{\'e}verine and Roeyers, Herbert and Raymaekers, Ruth and Allen, Albert J and Knijff, Simone and VERHELST, HELENE and Temmink, Alfons H and Smit, Leo ME and Rodriques-Pereira, Rob and Vandenberghe, Dirk and van Welsen, Inge and ter Schuren, Liesbeth and Al-Hakim, Mazim and Amin, Azad and Vlasveld, Laurens and Oosterlaan, Jaap and Sergeant, Joseph A},
  issn         = {1044-5463},
  journal      = {JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY},
  keyword      = {RESPONSE-INHIBITION,DISABILITY,DEFICIT HYPERACTIVITY DISORDER,WORKING-MEMORY,CHILDREN,PERFORMANCE,METAANALYSIS,ADULTS,EFFICACY,TASK},
  language     = {eng},
  number       = {6},
  pages        = {699--707},
  title        = {Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder},
  url          = {http://dx.doi.org/10.1089/cap.2009.0029},
  volume       = {19},
  year         = {2009},
}

Chicago
de Jong, Christien GW, Séverine Van De Voorde, Herbert Roeyers, Ruth Raymaekers, Albert J Allen, Simone Knijff, HELENE VERHELST, et al. 2009. “Differential Effects of Atomoxetine on Executive Functioning and Lexical Decision in Attention-deficit/hyperactivity Disorder and Reading Disorder.” Journal of Child and Adolescent Psychopharmacology 19 (6): 699–707.
APA
de Jong, C. G., Van De Voorde, S., Roeyers, H., Raymaekers, R., Allen, A. J., Knijff, S., VERHELST, H., et al. (2009). Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 19(6), 699–707.
Vancouver
1.
de Jong CG, Van De Voorde S, Roeyers H, Raymaekers R, Allen AJ, Knijff S, et al. Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 2009;19(6):699–707.
MLA
de Jong, Christien GW, Séverine Van De Voorde, Herbert Roeyers, et al. “Differential Effects of Atomoxetine on Executive Functioning and Lexical Decision in Attention-deficit/hyperactivity Disorder and Reading Disorder.” JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY 19.6 (2009): 699–707. Print.