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Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder

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Abstract
Objective: The effects of a promising pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), atomoxetine, were studied on executive functions in both ADHD and reading disorder (RD) because earlier research demonstrated an overlap in executive functioning deficits in both disorders. In addition, the effects of atomoxetine were explored on lexical decision. Methods: Sixteen children with ADHD, 20 children with ADHD + RD, 21 children with RD, and 26 normal controls were enrolled in a randomized placebo-controlled crossover study. Children were measured on visuospatial working memory, inhibition, and lexical decision on the day of randomization and following two 28-day medication periods. Results: Children with ADHD + RD showed improved visuospatial working memory performance and, to a lesser extent, improved inhibition following atomoxetine treatment compared to placebo. No differential effects of atomoxetine were found for lexical decision in comparison to placebo. In addition, no effects of atomoxetine were demonstrated in the ADHD and RD groups. Conclusion: Atomoxetine improved visuospatial working memory and to a lesser degree inhibition in children with ADHD + RD, which suggests differential developmental pathways for co-morbid ADHD + RD as compared to ADHD and RD alone.
Keywords
DISABILITY, RESPONSE-INHIBITION, DEFICIT HYPERACTIVITY DISORDER, WORKING-MEMORY, CHILDREN, PERFORMANCE, METAANALYSIS, ADULTS, EFFICACY, TASK

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Chicago
de Jong, Christien GW, Séverine Van De Voorde, Herbert Roeyers, Ruth Raymaekers, Albert J Allen, Simone Knijff, HELENE VERHELST, et al. 2009. “Differential Effects of Atomoxetine on Executive Functioning and Lexical Decision in Attention-deficit/hyperactivity Disorder and Reading Disorder.” Journal of Child and Adolescent Psychopharmacology 19 (6): 699–707.
APA
de Jong, C. G., Van De Voorde, S., Roeyers, H., Raymaekers, R., Allen, A. J., Knijff, S., VERHELST, H., et al. (2009). Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 19(6), 699–707.
Vancouver
1.
de Jong CG, Van De Voorde S, Roeyers H, Raymaekers R, Allen AJ, Knijff S, et al. Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder. JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY. 2009;19(6):699–707.
MLA
de Jong, Christien GW, Séverine Van De Voorde, Herbert Roeyers, et al. “Differential Effects of Atomoxetine on Executive Functioning and Lexical Decision in Attention-deficit/hyperactivity Disorder and Reading Disorder.” JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY 19.6 (2009): 699–707. Print.
@article{837750,
  abstract     = {Objective: The effects of a promising pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), atomoxetine, were studied on executive functions in both ADHD and reading disorder (RD) because earlier research demonstrated an overlap in executive functioning deficits in both disorders. In addition, the effects of atomoxetine were explored on lexical decision.
Methods: Sixteen children with ADHD, 20 children with ADHD + RD, 21 children with RD, and 26 normal controls were enrolled in a randomized placebo-controlled crossover study. Children were measured on visuospatial working memory, inhibition, and lexical decision on the day of randomization and following two 28-day medication periods.
Results: Children with ADHD + RD showed improved visuospatial working memory performance and, to a lesser extent, improved inhibition following atomoxetine treatment compared to placebo. No differential effects of atomoxetine were found for lexical decision in comparison to placebo. In addition, no effects of atomoxetine were demonstrated in the ADHD and RD groups.
Conclusion: Atomoxetine improved visuospatial working memory and to a lesser degree inhibition in children with ADHD + RD, which suggests differential developmental pathways for co-morbid ADHD + RD as compared to ADHD and RD alone.},
  author       = {de Jong, Christien GW and Van De Voorde, S{\'e}verine and Roeyers, Herbert and Raymaekers, Ruth and Allen, Albert J and Knijff, Simone and VERHELST, HELENE and Temmink, Alfons H and Smit, Leo ME and Rodriques-Pereira, Rob and Vandenberghe, Dirk and van Welsen, Inge and ter Schuren, Liesbeth and Al-Hakim, Mazim and Amin, Azad and Vlasveld, Laurens and Oosterlaan, Jaap and Sergeant, Joseph A},
  issn         = {1044-5463},
  journal      = {JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY},
  keyword      = {DISABILITY,RESPONSE-INHIBITION,DEFICIT HYPERACTIVITY DISORDER,WORKING-MEMORY,CHILDREN,PERFORMANCE,METAANALYSIS,ADULTS,EFFICACY,TASK},
  language     = {eng},
  number       = {6},
  pages        = {699--707},
  title        = {Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder},
  url          = {http://dx.doi.org/10.1089/cap.2009.0029},
  volume       = {19},
  year         = {2009},
}

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