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Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

Mathieu Vinken, Tatyana Doktorova UGent, Elke Decrock UGent, Luc Leybaert UGent, Tamara Vanhaecke and Vera Rogiers UGent (2009) CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 44(4). p.201-222
abstract
Direct communication between hepatocytes, mediated by gap junctions, constitutes a major regulatory platform in the control of liver homeostasis, ranging from hepatocellular proliferation to hepatocyte cell death. Inherent to this pivotal task, gap junction functionality is frequently disrupted upon impairment of the homeostatic balance, as occurs during liver toxicity and carcinogenicity. In the present paper, the deleterious effects of a number of chemical and biological toxic compounds on hepatic gap junctions are discussed, including environmental pollutants, biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. Particular attention is paid to the molecular mechanisms that underlie the abrogation of gap junction functionality. Since hepatic gap junctions are specifically targeted by tumor promoters and epigenetic carcinogens, both in vivo and in vitro, inhibition of gap junction functionality is considered as a suitable indicator for the detection of nongenotoxic hepatocarcinogenicity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
journal title
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Crit. Rev. Biochem. Mol. Biol.
volume
44
issue
4
pages
201 - 222
Web of Science type
Review
Web of Science id
000269259500004
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
10.216 (2009)
JCR rank
16/281 (2009)
JCR quartile
1 (2009)
ISSN
1040-9238
DOI
10.1080/10409230903061215
language
English
UGent publication?
yes
classification
A1
id
837573
handle
http://hdl.handle.net/1854/LU-837573
date created
2010-01-25 16:35:18
date last changed
2010-01-29 13:21:08
@article{837573,
  abstract     = {Direct communication between hepatocytes, mediated by gap junctions, constitutes a major regulatory platform in the control of liver homeostasis, ranging from hepatocellular proliferation to hepatocyte cell death. Inherent to this pivotal task, gap junction functionality is frequently disrupted upon impairment of the homeostatic balance, as occurs during liver toxicity and carcinogenicity. In the present paper, the deleterious effects of a number of chemical and biological toxic compounds on hepatic gap junctions are discussed, including environmental pollutants, biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. Particular attention is paid to the molecular mechanisms that underlie the abrogation of gap junction functionality. Since hepatic gap junctions are specifically targeted by tumor promoters and epigenetic carcinogens, both in vivo and in vitro, inhibition of gap junction functionality is considered as a suitable indicator for the detection of nongenotoxic hepatocarcinogenicity.},
  author       = {Vinken, Mathieu and Doktorova, Tatyana and Decrock, Elke and Leybaert, Luc and Vanhaecke, Tamara and Rogiers, Vera},
  issn         = {1040-9238},
  journal      = {CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY},
  language     = {eng},
  number       = {4},
  pages        = {201--222},
  title        = {Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity},
  url          = {http://dx.doi.org/10.1080/10409230903061215},
  volume       = {44},
  year         = {2009},
}

Chicago
Vinken, Mathieu, Tatyana Doktorova, Elke Decrock, Luc Leybaert, Tamara Vanhaecke, and Vera Rogiers. 2009. “Gap Junctional Intercellular Communication as a Target for Liver Toxicity and Carcinogenicity.” Critical Reviews in Biochemistry and Molecular Biology 44 (4): 201–222.
APA
Vinken, M., Doktorova, T., Decrock, E., Leybaert, L., Vanhaecke, T., & Rogiers, V. (2009). Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 44(4), 201–222.
Vancouver
1.
Vinken M, Doktorova T, Decrock E, Leybaert L, Vanhaecke T, Rogiers V. Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2009;44(4):201–22.
MLA
Vinken, Mathieu, Tatyana Doktorova, Elke Decrock, et al. “Gap Junctional Intercellular Communication as a Target for Liver Toxicity and Carcinogenicity.” CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 44.4 (2009): 201–222. Print.