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Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines

An De Weer UGent, Bruce Poppe UGent, Sarah Vergult UGent, Pieter Van Vlierberghe UGent, Marjan Petrick UGent, Robrecht De Bock, Yves Benoit UGent, Lucien Noens UGent, Anne De Paepe UGent and Nadine Van Roy UGent, et al. (2010) PLOS ONE. 5(1).
abstract
Chromosomal rearrangements involving the EVI1 proto-oncogene are a recurrent finding in myeloid leukemias and are indicative of a poor prognosis. Rearrangements of the EVI1 locus are often associated with monosomy 7 or cytogenetic detectable deletions of part of 7q. As EVI1 overexpression alone is not sufficient to induce leukemia, loss of a 7q tumour suppressor gene might be a required cooperating event. To test this hypothesis, we performed high-resolution array comparative genomic hybridization analysis of twelve EVI1 overexpressing patients and three EVI1 deregulated cell lines to search for 7q submicroscopic deletions. This analysis lead to the delineation of two critical regions, one of 0.39 Mb on 7q35 containing the CNTNAP2 gene and one of 1.33 Mb on chromosome bands 7q35–q36 comprising nine genes in EVI1 deregulated cell lines. These findings open the way to further studies aimed at identifying the culprit EVI1 implicated tumour suppressor genes on 7q.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
REARRANGEMENTS, GENE, ESTABLISHMENT, DISORDERS, INACTIVATION, DELETIONS, COMMON, LOCUS
journal title
PLOS ONE
Plos One
volume
5
issue
1
article_number
e8676
Web of Science type
Article
Web of Science id
000273554600028
JCR category
BIOLOGY
JCR impact factor
4.411 (2010)
JCR rank
12/84 (2010)
JCR quartile
1 (2010)
ISSN
1932-6203
DOI
10.1371/journal.pone.0008676
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
837449
handle
http://hdl.handle.net/1854/LU-837449
date created
2010-01-25 16:04:38
date last changed
2011-11-25 13:27:37
@article{837449,
  abstract     = {Chromosomal rearrangements involving the EVI1 proto-oncogene are a recurrent finding in myeloid leukemias and are indicative of a poor prognosis. Rearrangements of the EVI1 locus are often associated with monosomy 7 or cytogenetic detectable deletions of part of 7q. As EVI1 overexpression alone is not sufficient to induce leukemia, loss of a 7q tumour suppressor gene might be a required cooperating event. To test this hypothesis, we performed high-resolution array comparative genomic hybridization analysis of twelve EVI1 overexpressing patients and three EVI1 deregulated cell lines to search for 7q submicroscopic deletions. This analysis lead to the delineation of two critical regions, one of 0.39 Mb on 7q35 containing the CNTNAP2 gene and one of 1.33 Mb on chromosome bands 7q35--q36 comprising nine genes in EVI1 deregulated cell lines. These findings open the way to further studies aimed at identifying the culprit EVI1 implicated tumour suppressor genes on 7q.},
  articleno    = {e8676},
  author       = {De Weer, An and Poppe, Bruce and Vergult, Sarah and Van Vlierberghe, Pieter and Petrick, Marjan and De Bock, Robrecht and Benoit, Yves and Noens, Lucien and De Paepe, Anne and Van Roy, Nadine and Menten, Bj{\"o}rn and Speleman, Franki},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {REARRANGEMENTS,GENE,ESTABLISHMENT,DISORDERS,INACTIVATION,DELETIONS,COMMON,LOCUS},
  language     = {eng},
  number       = {1},
  title        = {Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines},
  url          = {http://dx.doi.org/10.1371/journal.pone.0008676},
  volume       = {5},
  year         = {2010},
}

Chicago
De Weer, An, Bruce Poppe, Sarah Vergult, Pieter Van Vlierberghe, Marjan Petrick, Robrecht De Bock, Yves Benoit, et al. 2010. “Identification of Two Critically Deleted Regions Within Chromosome Segment 7q35-q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines.” Plos One 5 (1).
APA
De Weer, An, Poppe, B., Vergult, S., Van Vlierberghe, P., Petrick, M., De Bock, R., Benoit, Y., et al. (2010). Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines. PLOS ONE, 5(1).
Vancouver
1.
De Weer A, Poppe B, Vergult S, Van Vlierberghe P, Petrick M, De Bock R, et al. Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines. PLOS ONE. 2010;5(1).
MLA
De Weer, An, Bruce Poppe, Sarah Vergult, et al. “Identification of Two Critically Deleted Regions Within Chromosome Segment 7q35-q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines.” PLOS ONE 5.1 (2010): n. pag. Print.