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Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines

An De Weer, Bruce Poppe (UGent) , Sarah Vergult (UGent) , Pieter Van Vlierberghe (UGent) , Marjan Petrick (UGent) , Robrecht De Bock, Yves Benoit, Lucien Noens (UGent) , Anne De Paepe (UGent) , Nadine Van Roy (UGent) , et al.
(2010) PLOS ONE. 5(1).
Author
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Abstract
Chromosomal rearrangements involving the EVI1 proto-oncogene are a recurrent finding in myeloid leukemias and are indicative of a poor prognosis. Rearrangements of the EVI1 locus are often associated with monosomy 7 or cytogenetic detectable deletions of part of 7q. As EVI1 overexpression alone is not sufficient to induce leukemia, loss of a 7q tumour suppressor gene might be a required cooperating event. To test this hypothesis, we performed high-resolution array comparative genomic hybridization analysis of twelve EVI1 overexpressing patients and three EVI1 deregulated cell lines to search for 7q submicroscopic deletions. This analysis lead to the delineation of two critical regions, one of 0.39 Mb on 7q35 containing the CNTNAP2 gene and one of 1.33 Mb on chromosome bands 7q35–q36 comprising nine genes in EVI1 deregulated cell lines. These findings open the way to further studies aimed at identifying the culprit EVI1 implicated tumour suppressor genes on 7q.
Keywords
REARRANGEMENTS, GENE, ESTABLISHMENT, DISORDERS, INACTIVATION, DELETIONS, COMMON, LOCUS

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MLA
De Weer, An, et al. “Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-Q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines.” PLOS ONE, vol. 5, no. 1, 2010, doi:10.1371/journal.pone.0008676.
APA
De Weer, A., Poppe, B., Vergult, S., Van Vlierberghe, P., Petrick, M., De Bock, R., … Speleman, F. (2010). Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines. PLOS ONE, 5(1). https://doi.org/10.1371/journal.pone.0008676
Chicago author-date
De Weer, An, Bruce Poppe, Sarah Vergult, Pieter Van Vlierberghe, Marjan Petrick, Robrecht De Bock, Yves Benoit, et al. 2010. “Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-Q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines.” PLOS ONE 5 (1). https://doi.org/10.1371/journal.pone.0008676.
Chicago author-date (all authors)
De Weer, An, Bruce Poppe, Sarah Vergult, Pieter Van Vlierberghe, Marjan Petrick, Robrecht De Bock, Yves Benoit, Lucien Noens, Anne De Paepe, Nadine Van Roy, Björn Menten, and Franki Speleman. 2010. “Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-Q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines.” PLOS ONE 5 (1). doi:10.1371/journal.pone.0008676.
Vancouver
1.
De Weer A, Poppe B, Vergult S, Van Vlierberghe P, Petrick M, De Bock R, et al. Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines. PLOS ONE. 2010;5(1).
IEEE
[1]
A. De Weer et al., “Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines,” PLOS ONE, vol. 5, no. 1, 2010.
@article{837449,
  abstract     = {{Chromosomal rearrangements involving the EVI1 proto-oncogene are a recurrent finding in myeloid leukemias and are indicative of a poor prognosis. Rearrangements of the EVI1 locus are often associated with monosomy 7 or cytogenetic detectable deletions of part of 7q. As EVI1 overexpression alone is not sufficient to induce leukemia, loss of a 7q tumour suppressor gene might be a required cooperating event. To test this hypothesis, we performed high-resolution array comparative genomic hybridization analysis of twelve EVI1 overexpressing patients and three EVI1 deregulated cell lines to search for 7q submicroscopic deletions. This analysis lead to the delineation of two critical regions, one of 0.39 Mb on 7q35 containing the CNTNAP2 gene and one of 1.33 Mb on chromosome bands 7q35–q36 comprising nine genes in EVI1 deregulated cell lines. These findings open the way to further studies aimed at identifying the culprit EVI1 implicated tumour suppressor genes on 7q.}},
  articleno    = {{e8676}},
  author       = {{De Weer, An and Poppe, Bruce and Vergult, Sarah and Van Vlierberghe, Pieter and Petrick, Marjan and De Bock, Robrecht and Benoit, Yves and Noens, Lucien and De Paepe, Anne and Van Roy, Nadine and Menten, Björn and Speleman, Franki}},
  issn         = {{1932-6203}},
  journal      = {{PLOS ONE}},
  keywords     = {{REARRANGEMENTS,GENE,ESTABLISHMENT,DISORDERS,INACTIVATION,DELETIONS,COMMON,LOCUS}},
  language     = {{eng}},
  number       = {{1}},
  title        = {{Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines}},
  url          = {{http://doi.org/10.1371/journal.pone.0008676}},
  volume       = {{5}},
  year         = {{2010}},
}

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