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Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles

Jasmien Hoebeeck UGent, BRAM DE WILDE UGent, Evi Michels UGent, Valerie Combaret, Nurten Yigit UGent, Els De Smet UGent, Nadine Van Roy UGent, Eric Stanbridge, Ning Ru and Genevieve Laureys UGent, et al. (2009) CANCER INVESTIGATION. 27(8). p.857-868
abstract
Pinpointing critical regions of recurrent loss may help localize tumor suppressor genes. To determine the regions of loss on chromosome 3p in neuroblastoma, we performed loss of heterozygosity analysis using 16 microsatellite markers in a series of 65 primary tumors and 29 neuroblastoma cell lines. In this study, we report the results and discuss the technical hurdles that we encountered during data generation and interpretation that are of relevance for current studies or tests employing microsatellites. To provide functional support for the implication of 3p tumor suppressor genes in this childhood malignancy, we performed a microcell-mediated chromosome 3 transfer in neuroblastoma cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PATTERNS, SUBGROUPS, LOSSES, Microcell-mediated chromosome transfer, Microsatellite, Neuroblastoma, Chromosome 3p, Loss of heterozygosity, 11Q, RESOLUTION, AMPLIFICATION, DELETION, CGH ANALYSIS, TUMOR-SUPPRESSOR GENES, COMPARATIVE GENOMIC HYBRIDIZATION
journal title
CANCER INVESTIGATION
Cancer Invest.
volume
27
issue
8
pages
857 - 868
Web of Science type
Article
Web of Science id
000269542600008
JCR category
ONCOLOGY
JCR impact factor
2.105 (2009)
JCR rank
96/163 (2009)
JCR quartile
3 (2009)
ISSN
0735-7907
DOI
10.1080/07357900902769731
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
837255
handle
http://hdl.handle.net/1854/LU-837255
date created
2010-01-25 15:16:13
date last changed
2011-03-31 15:18:53
@article{837255,
  abstract     = {Pinpointing critical regions of recurrent loss may help localize tumor suppressor genes. To determine the regions of loss on chromosome 3p in neuroblastoma, we performed loss of heterozygosity analysis using 16 microsatellite markers in a series of 65 primary tumors and 29 neuroblastoma cell lines. In this study, we report the results and discuss the technical hurdles that we encountered during data generation and interpretation that are of relevance for current studies or tests employing microsatellites. To provide functional support for the implication of 3p tumor suppressor genes in this childhood malignancy, we performed a microcell-mediated chromosome 3 transfer in neuroblastoma cells.},
  author       = {Hoebeeck, Jasmien and DE WILDE, BRAM and Michels, Evi and Combaret, Valerie and Yigit, Nurten and De Smet, Els and Van Roy, Nadine and Stanbridge, Eric and Ru, Ning and Laureys, Genevieve and De Paepe, Anne and Speleman, Franki and Vandesompele, Jo},
  issn         = {0735-7907},
  journal      = {CANCER INVESTIGATION},
  keyword      = {PATTERNS,SUBGROUPS,LOSSES,Microcell-mediated chromosome transfer,Microsatellite,Neuroblastoma,Chromosome 3p,Loss of heterozygosity,11Q,RESOLUTION,AMPLIFICATION,DELETION,CGH ANALYSIS,TUMOR-SUPPRESSOR GENES,COMPARATIVE GENOMIC HYBRIDIZATION},
  language     = {eng},
  number       = {8},
  pages        = {857--868},
  title        = {Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles},
  url          = {http://dx.doi.org/10.1080/07357900902769731},
  volume       = {27},
  year         = {2009},
}

Chicago
Hoebeeck, Jasmien, BRAM DE WILDE, Evi Michels, Valerie Combaret, Nurten Yigit, Els De Smet, Nadine Van Roy, et al. 2009. “Chromosome 3p Microsatellite Allelotyping in Neuroblastoma: a Report on the Technical Hurdles.” Cancer Investigation 27 (8): 857–868.
APA
Hoebeeck, J., DE WILDE, B., Michels, E., Combaret, V., Yigit, N., De Smet, E., Van Roy, N., et al. (2009). Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles. CANCER INVESTIGATION, 27(8), 857–868.
Vancouver
1.
Hoebeeck J, DE WILDE B, Michels E, Combaret V, Yigit N, De Smet E, et al. Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles. CANCER INVESTIGATION. 2009;27(8):857–68.
MLA
Hoebeeck, Jasmien, BRAM DE WILDE, Evi Michels, et al. “Chromosome 3p Microsatellite Allelotyping in Neuroblastoma: a Report on the Technical Hurdles.” CANCER INVESTIGATION 27.8 (2009): 857–868. Print.