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Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles

(2009) CANCER INVESTIGATION. 27(8). p.857-868
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Abstract
Pinpointing critical regions of recurrent loss may help localize tumor suppressor genes. To determine the regions of loss on chromosome 3p in neuroblastoma, we performed loss of heterozygosity analysis using 16 microsatellite markers in a series of 65 primary tumors and 29 neuroblastoma cell lines. In this study, we report the results and discuss the technical hurdles that we encountered during data generation and interpretation that are of relevance for current studies or tests employing microsatellites. To provide functional support for the implication of 3p tumor suppressor genes in this childhood malignancy, we performed a microcell-mediated chromosome 3 transfer in neuroblastoma cells.
Keywords
SUBGROUPS, PATTERNS, LOSSES, Microcell-mediated chromosome transfer, Microsatellite, Neuroblastoma, Chromosome 3p, Loss of heterozygosity, 11Q, RESOLUTION, AMPLIFICATION, DELETION, CGH ANALYSIS, TUMOR-SUPPRESSOR GENES, COMPARATIVE GENOMIC HYBRIDIZATION

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Chicago
Hoebeeck, Jasmien, Bram De Wilde, Evi Michels, Valerie Combaret, Nurten Yigit, Els De Smet, Nadine Van Roy, et al. 2009. “Chromosome 3p Microsatellite Allelotyping in Neuroblastoma: a Report on the Technical Hurdles.” Cancer Investigation 27 (8): 857–868.
APA
Hoebeeck, J., De Wilde, B., Michels, E., Combaret, V., Yigit, N., De Smet, E., Van Roy, N., et al. (2009). Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles. CANCER INVESTIGATION, 27(8), 857–868.
Vancouver
1.
Hoebeeck J, De Wilde B, Michels E, Combaret V, Yigit N, De Smet E, et al. Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles. CANCER INVESTIGATION. 2009;27(8):857–68.
MLA
Hoebeeck, Jasmien, Bram De Wilde, Evi Michels, et al. “Chromosome 3p Microsatellite Allelotyping in Neuroblastoma: a Report on the Technical Hurdles.” CANCER INVESTIGATION 27.8 (2009): 857–868. Print.
@article{837255,
  abstract     = {Pinpointing critical regions of recurrent loss may help localize tumor suppressor genes. To determine the regions of loss on chromosome 3p in neuroblastoma, we performed loss of heterozygosity analysis using 16 microsatellite markers in a series of 65 primary tumors and 29 neuroblastoma cell lines. In this study, we report the results and discuss the technical hurdles that we encountered during data generation and interpretation that are of relevance for current studies or tests employing microsatellites. To provide functional support for the implication of 3p tumor suppressor genes in this childhood malignancy, we performed a microcell-mediated chromosome 3 transfer in neuroblastoma cells.},
  author       = {Hoebeeck, Jasmien and De Wilde, Bram and Michels, Evi and Combaret, Valerie and Yigit, Nurten and De Smet, Els and Van Roy, Nadine and Stanbridge, Eric and Ru, Ning and Laureys, Genevieve and De Paepe, Anne and Speleman, Franki and Vandesompele, Jo},
  issn         = {0735-7907},
  journal      = {CANCER INVESTIGATION},
  keyword      = {SUBGROUPS,PATTERNS,LOSSES,Microcell-mediated chromosome transfer,Microsatellite,Neuroblastoma,Chromosome 3p,Loss of heterozygosity,11Q,RESOLUTION,AMPLIFICATION,DELETION,CGH ANALYSIS,TUMOR-SUPPRESSOR GENES,COMPARATIVE GENOMIC HYBRIDIZATION},
  language     = {eng},
  number       = {8},
  pages        = {857--868},
  title        = {Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles},
  url          = {http://dx.doi.org/10.1080/07357900902769731},
  volume       = {27},
  year         = {2009},
}

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