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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) IMMUNITY. 30(4). p.566-575
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Abstract
Virus-induced interlukin-1 beta (IL-1 beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome resulting in caspase-1 activation. Here, we demonstrated that NIrp3(-/-) and Casp1(-/-) mice were more susceptible than wildtype mice after infection with a pathogenic influenza A virus. This enhanced morbidity correlated with decreased neutrophil and monocyte recruitment and reduced cytokine and chemokine production. Despite the effect on innate immunity, cryopyrin-deficiency was not associated with any obvious defect in virus control or on the later emergence of the adaptive response. Early epithelial necrosis was, however, more severe in the infected mutants, with extensive collagen deposition leading to later respiratory compromise. These findings reveal a function of the cryopyrin inflammasome in healing responses. Thus, cryopyrin and caspase-1 are central to both innate immunity and to moderating lung pathology in influenza pneumonia.
Keywords
T-CELLS, INFECTION, RIG-I, LUNG INJURY, DOUBLE-STRANDED-RNA, IL-1-BETA-CONVERTING ENZYME, ANTIVIRAL RESPONSES, ADAPTIVE IMMUNITY, MICE DEFICIENT, HUMAN MACROPHAGES

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Citation

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MLA
Thomas, PG, et al. “The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1.” IMMUNITY, vol. 30, no. 4, CELL PRESS, 2009, pp. 566–75, doi:10.1016/j.immuni.2009.02.006.
APA
Thomas, P., Dash, P., Aldridge, J., Ellebedy, A., Reynolds, C., Funk, A., … Kanneganti, T. (2009). The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1. IMMUNITY, 30(4), 566–575. https://doi.org/10.1016/j.immuni.2009.02.006
Chicago author-date
Thomas, PG, P Dash, JR Aldridge, AH Ellebedy, C Reynolds, AJ Funk, WJ Martin, et al. 2009. “The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1.” IMMUNITY 30 (4): 566–75. https://doi.org/10.1016/j.immuni.2009.02.006.
Chicago author-date (all authors)
Thomas, PG, P Dash, JR Aldridge, AH Ellebedy, C Reynolds, AJ Funk, WJ Martin, Mohamed Lamkanfi, RJ Webby, KL Boyd, PC Doherty, and TD Kanneganti. 2009. “The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1.” IMMUNITY 30 (4): 566–575. doi:10.1016/j.immuni.2009.02.006.
Vancouver
1.
Thomas P, Dash P, Aldridge J, Ellebedy A, Reynolds C, Funk A, et al. The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1. IMMUNITY. 2009;30(4):566–75.
IEEE
[1]
P. Thomas et al., “The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1,” IMMUNITY, vol. 30, no. 4, pp. 566–575, 2009.
@article{836828,
  abstract     = {{Virus-induced interlukin-1 beta (IL-1 beta) and IL-18 production in macrophages are mediated via caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome resulting in caspase-1 activation. Here, we demonstrated that NIrp3(-/-) and Casp1(-/-) mice were more susceptible than wildtype mice after infection with a pathogenic influenza A virus. This enhanced morbidity correlated with decreased neutrophil and monocyte recruitment and reduced cytokine and chemokine production. Despite the effect on innate immunity, cryopyrin-deficiency was not associated with any obvious defect in virus control or on the later emergence of the adaptive response. Early epithelial necrosis was, however, more severe in the infected mutants, with extensive collagen deposition leading to later respiratory compromise. These findings reveal a function of the cryopyrin inflammasome in healing responses. Thus, cryopyrin and caspase-1 are central to both innate immunity and to moderating lung pathology in influenza pneumonia.}},
  author       = {{Thomas, PG and Dash, P and Aldridge, JR and Ellebedy, AH and Reynolds, C and Funk, AJ and Martin, WJ and Lamkanfi, Mohamed and Webby, RJ and Boyd, KL and Doherty, PC and Kanneganti, TD}},
  issn         = {{1074-7613}},
  journal      = {{IMMUNITY}},
  keywords     = {{T-CELLS,INFECTION,RIG-I,LUNG INJURY,DOUBLE-STRANDED-RNA,IL-1-BETA-CONVERTING ENZYME,ANTIVIRAL RESPONSES,ADAPTIVE IMMUNITY,MICE DEFICIENT,HUMAN MACROPHAGES}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{566--575}},
  publisher    = {{CELL PRESS}},
  title        = {{The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1}},
  url          = {{http://doi.org/10.1016/j.immuni.2009.02.006}},
  volume       = {{30}},
  year         = {{2009}},
}

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