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The use of tannins to control Salmonella Typhimurium infections in pigs

Alexander Van Parys UGent, Filip Boyen UGent, Jeroen Dewulf UGent, Freddy Haesebrouck UGent and Frank Pasmans UGent (2010) ZOONOSES AND PUBLIC HEALTH. 57(6). p.423-428
abstract
The aim of this study was to determine whether a hydrolysable tannin extract of sweet chestnut wood (Globatan (R)) has an inhibitory effect on Salmonella Typhimurium survival both in vitro and in vivo in pigs. In a first experiment, the minimal inhibitory concentration of Globatan (R) on 57 Salmonella Typhimurium isolates was determined. For all isolates, an MIC of 160-320 mu g/ml was found. The second in vitro study revealed that Salmonella growth was strongly reduced using Globatan (R) concentrations of 25-50 mu g/ml and nearly completely inhibited at a concentration of 100 mu g/ml Globatan (R). In an in vivo trial, two groups of six piglets, each group receiving feed with or without the addition of Globatan (R) (3 g/kg), were orally inoculated with 107 colony forming units of a Salmonella Typhimurium strain. Globatan (R) had no effect on faecal excretion of Salmonella, and no differences in colonization of the intestines and internal organs were demonstrated in pigs euthanized at 4 days post-inoculation. In conclusion, the hydrolysable tannin extract used in this study showed strong action against Salmonella Typhimurium in vitro but not in vivo.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Salmonella Typhimurium, pigs, in vivo trial, tannins, ANTIMICROBIAL PROPERTIES, INTESTINAL PATHOGENS, BERRY PHENOLICS, FATTY-ACIDS, COLONIZATION, VIRULENCE, BACTERIA, PLANTS, PATTERNS, EXTRACTS
journal title
ZOONOSES AND PUBLIC HEALTH
Zoonoses Public Health
volume
57
issue
6
pages
423 - 428
Web of Science type
Article
Web of Science id
000280995900008
JCR category
VETERINARY SCIENCES
JCR impact factor
2.22 (2010)
JCR rank
12/145 (2010)
JCR quartile
1 (2010)
ISSN
1863-1959
DOI
10.1111/j.1863-2378.2009.01242.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
836630
handle
http://hdl.handle.net/1854/LU-836630
date created
2010-01-25 13:43:22
date last changed
2010-10-07 16:12:56
@article{836630,
  abstract     = {The aim of this study was to determine whether a hydrolysable tannin extract of sweet chestnut wood (Globatan (R)) has an inhibitory effect on Salmonella Typhimurium survival both in vitro and in vivo in pigs. In a first experiment, the minimal inhibitory concentration of Globatan (R) on 57 Salmonella Typhimurium isolates was determined. For all isolates, an MIC of 160-320 mu g/ml was found. The second in vitro study revealed that Salmonella growth was strongly reduced using Globatan (R) concentrations of 25-50 mu g/ml and nearly completely inhibited at a concentration of 100 mu g/ml Globatan (R). In an in vivo trial, two groups of six piglets, each group receiving feed with or without the addition of Globatan (R) (3 g/kg), were orally inoculated with 107 colony forming units of a Salmonella Typhimurium strain. Globatan (R) had no effect on faecal excretion of Salmonella, and no differences in colonization of the intestines and internal organs were demonstrated in pigs euthanized at 4 days post-inoculation. In conclusion, the hydrolysable tannin extract used in this study showed strong action against Salmonella Typhimurium in vitro but not in vivo.},
  author       = {Van Parys, Alexander and Boyen, Filip and Dewulf, Jeroen and Haesebrouck, Freddy and Pasmans, Frank},
  issn         = {1863-1959},
  journal      = {ZOONOSES AND PUBLIC HEALTH},
  keyword      = {Salmonella Typhimurium,pigs,in vivo trial,tannins,ANTIMICROBIAL PROPERTIES,INTESTINAL PATHOGENS,BERRY PHENOLICS,FATTY-ACIDS,COLONIZATION,VIRULENCE,BACTERIA,PLANTS,PATTERNS,EXTRACTS},
  language     = {eng},
  number       = {6},
  pages        = {423--428},
  title        = {The use of tannins to control Salmonella Typhimurium infections in pigs},
  url          = {http://dx.doi.org/10.1111/j.1863-2378.2009.01242.x},
  volume       = {57},
  year         = {2010},
}

Chicago
Van Parys, Alexander, Filip Boyen, Jeroen Dewulf, Freddy Haesebrouck, and Frank Pasmans. 2010. “The Use of Tannins to Control Salmonella Typhimurium Infections in Pigs.” Zoonoses and Public Health 57 (6): 423–428.
APA
Van Parys, A., Boyen, F., Dewulf, J., Haesebrouck, F., & Pasmans, F. (2010). The use of tannins to control Salmonella Typhimurium infections in pigs. ZOONOSES AND PUBLIC HEALTH, 57(6), 423–428.
Vancouver
1.
Van Parys A, Boyen F, Dewulf J, Haesebrouck F, Pasmans F. The use of tannins to control Salmonella Typhimurium infections in pigs. ZOONOSES AND PUBLIC HEALTH. 2010;57(6):423–8.
MLA
Van Parys, Alexander, Filip Boyen, Jeroen Dewulf, et al. “The Use of Tannins to Control Salmonella Typhimurium Infections in Pigs.” ZOONOSES AND PUBLIC HEALTH 57.6 (2010): 423–428. Print.