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Lumen enhancement influences absolute noncalcific plaque density on multislice computed tomography coronary angiography: ex-vivo validation and in-vivo demonstration

Filippo Cademartiri, Giuseppe Runza, Alessandro Palumbo, Erica Maffei, Claudia Martini, Eugene P McFadden, Pamela Somers UGent, Michiel Knaapen, Stefan Verheye and Annick Weustink, et al. (2010) Journal of cardiovascular medicine (Hagerstown, Md.). 11(5). p.337-344
abstract
AIM: The purpose of this study was to define the in-vitro and in-vivo effects of intracoronary enhancement on the absolute density values of coronary plaques during multislice computed tomography. METHODS: We studied seven ex-vivo left coronary artery specimens surrounded by olive oil and filled with isotonic saline and four solutions with decreasing dilutions of contrast material: control (isotonic saline), 1/200, 1/80, 1/50, and 1/20. The multislice computed tomography protocol was: slice/collimation 32 x 2 x 0.6 mm and rotation time 330 ms. The attenuation (Hounsfield units) value of atherosclerotic plaques was measured for each dilution in lumen, plaque (noncalcified coronary wall thickening), calcium, and surrounding oil. In-vivo assessment was performed in 12 patients (nine men; mean age 58.7 +/- 9.9 years) who underwent two subsequent multislice computed tomography scans (arterial and delayed) after intravenous administration of a single bolus of contrast material. The attenuation values of lumen and plaques during arterial and delayed computed tomography were compared. The results were compared with one-way analysis of variance and correlated with Pearson's test. RESULTS: Mean lumen (45 +/- 38-669 +/- 151 HU) and plaque (11 +/- 35-101 +/- 72 HU) attenuation differed significantly (P < 0.001) among the different dilutions. The attenuation of lumen and plaque of coronary plaques showed moderate correlation (r = 0.54, P < 0.001). The mean attenuation value in vivo for the arterial and delayed phase scans differed significantly (P < 0.001) for lumen (325 +/- 70 and 174 +/- 46 HU, respectively) and plaque (138 +/- 71 and 100 +/- 52 HU, respectively). CONCLUSION: Coronary plaque attenuation values are significantly modified by differences in lumen contrast densities both ex vivo and in vivo. This should be taken into account when considering the distinction between lipid and fibrous plaques.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
Journal of cardiovascular medicine (Hagerstown, Md.)
J Cardiovasc Med (Hagerstown)
volume
11
issue
5
pages
337 - 344
publisher
Lippincott Williams & Wilkins
place of publication
United States
Web of Science type
article
Web of Science id
000276836600003
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
0.786 (2010)
JCR rank
97/114 (2010)
JCR quartile
4 (2010)
ISSN
1558-2035
1558-2027
DOI
10.2459/JCM.0b013e3283312400
language
English
UGent publication?
no
classification
A1
id
835937
handle
http://hdl.handle.net/1854/LU-835937
date created
2010-01-24 13:47:24
date last changed
2010-06-22 15:20:10
@article{835937,
  abstract     = {AIM: The purpose of this study was to define the in-vitro and in-vivo effects of intracoronary enhancement on the absolute density values of coronary plaques during multislice computed tomography. METHODS: We studied seven ex-vivo left coronary artery specimens surrounded by olive oil and filled with isotonic saline and four solutions with decreasing dilutions of contrast material: control (isotonic saline), 1/200, 1/80, 1/50, and 1/20. The multislice computed tomography protocol was: slice/collimation 32 x 2 x 0.6 mm and rotation time 330 ms. The attenuation (Hounsfield units) value of atherosclerotic plaques was measured for each dilution in lumen, plaque (noncalcified coronary wall thickening), calcium, and surrounding oil. In-vivo assessment was performed in 12 patients (nine men; mean age 58.7 +/- 9.9 years) who underwent two subsequent multislice computed tomography scans (arterial and delayed) after intravenous administration of a single bolus of contrast material. The attenuation values of lumen and plaques during arterial and delayed computed tomography were compared. The results were compared with one-way analysis of variance and correlated with Pearson's test. RESULTS: Mean lumen (45 +/- 38-669 +/- 151 HU) and plaque (11 +/- 35-101 +/- 72 HU) attenuation differed significantly (P {\textlangle} 0.001) among the different dilutions. The attenuation of lumen and plaque of coronary plaques showed moderate correlation (r = 0.54, P {\textlangle} 0.001). The mean attenuation value in vivo for the arterial and delayed phase scans differed significantly (P {\textlangle} 0.001) for lumen (325 +/- 70 and 174 +/- 46 HU, respectively) and plaque (138 +/- 71 and 100 +/- 52 HU, respectively). CONCLUSION: Coronary plaque attenuation values are significantly modified by differences in lumen contrast densities both ex vivo and in vivo. This should be taken into account when considering the distinction between lipid and fibrous plaques.},
  author       = {Cademartiri, Filippo and Runza, Giuseppe and Palumbo, Alessandro and Maffei, Erica  and Martini, Claudia and McFadden, Eugene P and Somers, Pamela and Knaapen, Michiel and Verheye, Stefan and Weustink, Annick and Mollet, Nico and de Feyter, Pim  and Hamers, Ronald and Bruining, Nico},
  issn         = {1558-2035},
  journal      = {Journal of cardiovascular medicine (Hagerstown, Md.)},
  language     = {eng},
  number       = {5},
  pages        = {337--344},
  publisher    = {Lippincott Williams \& Wilkins},
  title        = {Lumen enhancement influences absolute noncalcific plaque density on multislice computed tomography coronary angiography: ex-vivo validation and in-vivo demonstration},
  url          = {http://dx.doi.org/10.2459/JCM.0b013e3283312400},
  volume       = {11},
  year         = {2010},
}

Chicago
Cademartiri, Filippo, Giuseppe Runza, Alessandro Palumbo, Erica Maffei, Claudia Martini, Eugene P McFadden, Pamela Somers, et al. 2010. “Lumen Enhancement Influences Absolute Noncalcific Plaque Density on Multislice Computed Tomography Coronary Angiography: Ex-vivo Validation and In-vivo Demonstration.” Journal of Cardiovascular Medicine (Hagerstown, Md.) 11 (5): 337–344.
APA
Cademartiri, F., Runza, G., Palumbo, A., Maffei, E., Martini, C., McFadden, E. P., Somers, P., et al. (2010). Lumen enhancement influences absolute noncalcific plaque density on multislice computed tomography coronary angiography: ex-vivo validation and in-vivo demonstration. Journal of cardiovascular medicine (Hagerstown, Md.), 11(5), 337–344.
Vancouver
1.
Cademartiri F, Runza G, Palumbo A, Maffei E, Martini C, McFadden EP, et al. Lumen enhancement influences absolute noncalcific plaque density on multislice computed tomography coronary angiography: ex-vivo validation and in-vivo demonstration. Journal of cardiovascular medicine (Hagerstown, Md.). United States: Lippincott Williams & Wilkins; 2010;11(5):337–44.
MLA
Cademartiri, Filippo, Giuseppe Runza, Alessandro Palumbo, et al. “Lumen Enhancement Influences Absolute Noncalcific Plaque Density on Multislice Computed Tomography Coronary Angiography: Ex-vivo Validation and In-vivo Demonstration.” Journal of cardiovascular medicine (Hagerstown, Md.) 11.5 (2010): 337–344. Print.