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Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma

Seok-Geun Lee, Hyun Y. Jeon, Zhaozhong Su, Joanna E. Richards, Nikollaq Vozhilla, Devanand Sarkar, Tom Van Maerken UGent and Paul B. Fisher (2009) Oncogene. 28(26). p.2476-2484
abstract
Neuroblastoma, derived from neural crest progenitor cells, is the most common extracranial solid tumor of childhood. Astrocyte elevated gene-1 (AEG-1) is a primary mediator of tumor progression and metastasis in several human cancers. In this study, we investigated the potential contribution of AEG-1 in human neuroblastoma pathogenesis. AEG-1 expression was significantly elevated in neuroblastoma patient-derived samples and neuroblastoma cell lines as compared with normal peripheral nerve tissues, normal astrocytes and immortalized melanocytes. Knockdown of AEG-1 by small interfering RNA reduced the tumorigenic properties of highly aggressive neuroblastoma cells. Conversely, over-expression of AEG-1 enhanced proliferation and expression of the transformed state in less aggressive neuroblastoma cells through activation of the phosphatidylinositol 3-kinase-Akt-signaling pathway and stabilization of MYCN. These provocative results indicate that AEG-1 may play a crucial role in the pathogenesis of neuroblastoma and could represent a potential target for therapeutic intervention.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PI3K, MYCN, neuroblastoma, AEG-1, Akt
journal title
Oncogene
volume
28
issue
26
pages
2476 - 2484
Web of Science type
Article
Web of Science id
000267601400006
JCR category
ONCOLOGY
JCR impact factor
7.135 (2009)
JCR rank
14/163 (2009)
JCR quartile
1 (2009)
ISSN
0950-9232
DOI
10.1038/onc.2009.93
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
835714
handle
http://hdl.handle.net/1854/LU-835714
date created
2010-01-23 21:29:34
date last changed
2015-06-17 11:20:34
@article{835714,
  abstract     = {Neuroblastoma, derived from neural crest progenitor cells, is the most common extracranial solid tumor of childhood. Astrocyte elevated gene-1 (AEG-1) is a primary mediator of tumor progression and metastasis in several human cancers. In this study, we investigated the potential contribution of AEG-1 in human neuroblastoma pathogenesis. AEG-1 expression was significantly elevated in neuroblastoma patient-derived samples and neuroblastoma cell lines as compared with normal peripheral nerve tissues, normal astrocytes and immortalized melanocytes. Knockdown of AEG-1 by small interfering RNA reduced the tumorigenic properties of highly aggressive neuroblastoma cells. Conversely, over-expression of AEG-1 enhanced proliferation and expression of the transformed state in less aggressive neuroblastoma cells through activation of the phosphatidylinositol 3-kinase-Akt-signaling pathway and stabilization of MYCN. These provocative results indicate that AEG-1 may play a crucial role in the pathogenesis of neuroblastoma and could represent a potential target for therapeutic intervention.},
  author       = {Lee, Seok-Geun and Jeon, Hyun Y. and Su, Zhaozhong and Richards, Joanna E. and Vozhilla, Nikollaq and Sarkar, Devanand and Van Maerken, Tom and Fisher, Paul B.},
  issn         = {0950-9232},
  journal      = {Oncogene},
  keyword      = {PI3K,MYCN,neuroblastoma,AEG-1,Akt},
  language     = {eng},
  number       = {26},
  pages        = {2476--2484},
  title        = {Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma},
  url          = {http://dx.doi.org/10.1038/onc.2009.93},
  volume       = {28},
  year         = {2009},
}

Chicago
Lee, Seok-Geun, Hyun Y. Jeon, Zhaozhong Su, Joanna E. Richards, Nikollaq Vozhilla, Devanand Sarkar, Tom Van Maerken, and Paul B. Fisher. 2009. “Astrocyte Elevated Gene-1 Contributes to the Pathogenesis of Neuroblastoma.” Oncogene 28 (26): 2476–2484.
APA
Lee, S.-G., Jeon, H. Y., Su, Z., Richards, J. E., Vozhilla, N., Sarkar, D., Van Maerken, T., et al. (2009). Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene, 28(26), 2476–2484.
Vancouver
1.
Lee S-G, Jeon HY, Su Z, Richards JE, Vozhilla N, Sarkar D, et al. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene. 2009;28(26):2476–84.
MLA
Lee, Seok-Geun, Hyun Y. Jeon, Zhaozhong Su, et al. “Astrocyte Elevated Gene-1 Contributes to the Pathogenesis of Neuroblastoma.” Oncogene 28.26 (2009): 2476–2484. Print.