Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma
- Author
- Seok-Geun Lee, Hyun Y. Jeon, Zhaozhong Su, Joanna E. Richards, Nikollaq Vozhilla, Devanand Sarkar, Tom Van Maerken (UGent) and Paul B. Fisher
- Organization
- Abstract
- Neuroblastoma, derived from neural crest progenitor cells, is the most common extracranial solid tumor of childhood. Astrocyte elevated gene-1 (AEG-1) is a primary mediator of tumor progression and metastasis in several human cancers. In this study, we investigated the potential contribution of AEG-1 in human neuroblastoma pathogenesis. AEG-1 expression was significantly elevated in neuroblastoma patient-derived samples and neuroblastoma cell lines as compared with normal peripheral nerve tissues, normal astrocytes and immortalized melanocytes. Knockdown of AEG-1 by small interfering RNA reduced the tumorigenic properties of highly aggressive neuroblastoma cells. Conversely, over-expression of AEG-1 enhanced proliferation and expression of the transformed state in less aggressive neuroblastoma cells through activation of the phosphatidylinositol 3-kinase-Akt-signaling pathway and stabilization of MYCN. These provocative results indicate that AEG-1 may play a crucial role in the pathogenesis of neuroblastoma and could represent a potential target for therapeutic intervention.
- Keywords
- PI3K, MYCN, neuroblastoma, AEG-1, Akt
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-835714
- MLA
- Lee, Seok-Geun, et al. “Astrocyte Elevated Gene-1 Contributes to the Pathogenesis of Neuroblastoma.” Oncogene, vol. 28, no. 26, 2009, pp. 2476–84, doi:10.1038/onc.2009.93.
- APA
- Lee, S.-G., Jeon, H. Y., Su, Z., Richards, J. E., Vozhilla, N., Sarkar, D., … Fisher, P. B. (2009). Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene, 28(26), 2476–2484. https://doi.org/10.1038/onc.2009.93
- Chicago author-date
- Lee, Seok-Geun, Hyun Y. Jeon, Zhaozhong Su, Joanna E. Richards, Nikollaq Vozhilla, Devanand Sarkar, Tom Van Maerken, and Paul B. Fisher. 2009. “Astrocyte Elevated Gene-1 Contributes to the Pathogenesis of Neuroblastoma.” Oncogene 28 (26): 2476–84. https://doi.org/10.1038/onc.2009.93.
- Chicago author-date (all authors)
- Lee, Seok-Geun, Hyun Y. Jeon, Zhaozhong Su, Joanna E. Richards, Nikollaq Vozhilla, Devanand Sarkar, Tom Van Maerken, and Paul B. Fisher. 2009. “Astrocyte Elevated Gene-1 Contributes to the Pathogenesis of Neuroblastoma.” Oncogene 28 (26): 2476–2484. doi:10.1038/onc.2009.93.
- Vancouver
- 1.Lee S-G, Jeon HY, Su Z, Richards JE, Vozhilla N, Sarkar D, et al. Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma. Oncogene. 2009;28(26):2476–84.
- IEEE
- [1]S.-G. Lee et al., “Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma,” Oncogene, vol. 28, no. 26, pp. 2476–2484, 2009.
@article{835714, abstract = {{Neuroblastoma, derived from neural crest progenitor cells, is the most common extracranial solid tumor of childhood. Astrocyte elevated gene-1 (AEG-1) is a primary mediator of tumor progression and metastasis in several human cancers. In this study, we investigated the potential contribution of AEG-1 in human neuroblastoma pathogenesis. AEG-1 expression was significantly elevated in neuroblastoma patient-derived samples and neuroblastoma cell lines as compared with normal peripheral nerve tissues, normal astrocytes and immortalized melanocytes. Knockdown of AEG-1 by small interfering RNA reduced the tumorigenic properties of highly aggressive neuroblastoma cells. Conversely, over-expression of AEG-1 enhanced proliferation and expression of the transformed state in less aggressive neuroblastoma cells through activation of the phosphatidylinositol 3-kinase-Akt-signaling pathway and stabilization of MYCN. These provocative results indicate that AEG-1 may play a crucial role in the pathogenesis of neuroblastoma and could represent a potential target for therapeutic intervention.}}, author = {{Lee, Seok-Geun and Jeon, Hyun Y. and Su, Zhaozhong and Richards, Joanna E. and Vozhilla, Nikollaq and Sarkar, Devanand and Van Maerken, Tom and Fisher, Paul B.}}, issn = {{0950-9232}}, journal = {{Oncogene}}, keywords = {{PI3K,MYCN,neuroblastoma,AEG-1,Akt}}, language = {{eng}}, number = {{26}}, pages = {{2476--2484}}, title = {{Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma}}, url = {{http://doi.org/10.1038/onc.2009.93}}, volume = {{28}}, year = {{2009}}, }
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