Ghent University Academic Bibliography

Advanced

Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies

Marc Twagirumukiza UGent, An Cosijns UGent, Eveline Pringels, Jean Paul Remon UGent, Chris Vervaet UGent and Lucas Van Bortel UGent (2009) AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 81(5). p.776-781
abstract
The objective of this study was to assess the quality of antihypertensive drugs and to investigate the influence of tropical storage conditions. Drug content and in vitro dissolution tests were performed on 10 test formulations (from Rwanda) and 6 reference formulations (from Belgium or France) after purchase and after 6-month storage under long-term (25 +/- 2 degrees C and 60 +/- 5% relative humidity [RH]) and accelerated (40 +/- 2 degrees C and 75 +/- 5% RH) testing conditions. Twenty percent of test formulations were of substandard content at the time of purchase. After 6 months at accelerated testing conditions, 7 of 10 test formulations were substandard in content and 8 were substandard for the combined criteria of drug content and dissolution, whereas no reference drug became substandard. This study shows that, apart from some drugs being already substandard from purchase, accelerated testing conditions (simulating tropical climate) have deleterious effects on the majority of antihypertensive drug formulations found in the Rwandan market.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
COUNTERFEIT, STABILITY, IN-VITRO DISSOLUTION, SUB-SAHARAN AFRICA, VIVO BIOAVAILABILITY, ANTIMALARIAL-DRUGS, STORAGE-CONDITIONS, SUBSTANDARD DRUGS, FAKE DRUGS, GLOBAL BURDEN
journal title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Am. J. Trop. Med. Hyg.
volume
81
issue
5
pages
776 - 781
Web of Science type
Article
Web of Science id
000271956500010
JCR category
TROPICAL MEDICINE
JCR impact factor
2.795 (2009)
JCR rank
3/17 (2009)
JCR quartile
1 (2009)
ISSN
0002-9637
DOI
10.4269/ajtmh.2009.09-0109
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
835273
handle
http://hdl.handle.net/1854/LU-835273
date created
2010-01-22 15:47:51
date last changed
2011-01-11 09:06:47
@article{835273,
  abstract     = {The objective of this study was to assess the quality of antihypertensive drugs and to investigate the influence of tropical storage conditions. Drug content and in vitro dissolution tests were performed on 10 test formulations (from Rwanda) and 6 reference formulations (from Belgium or France) after purchase and after 6-month storage under long-term (25 +/- 2 degrees C and 60 +/- 5\% relative humidity [RH]) and accelerated (40 +/- 2 degrees C and 75 +/- 5\% RH) testing conditions. Twenty percent of test formulations were of substandard content at the time of purchase. After 6 months at accelerated testing conditions, 7 of 10 test formulations were substandard in content and 8 were substandard for the combined criteria of drug content and dissolution, whereas no reference drug became substandard. This study shows that, apart from some drugs being already substandard from purchase, accelerated testing conditions (simulating tropical climate) have deleterious effects on the majority of antihypertensive drug formulations found in the Rwandan market.},
  author       = {Twagirumukiza, Marc and Cosijns, An and Pringels, Eveline and Remon, Jean Paul and Vervaet, Chris and Van Bortel, Lucas},
  issn         = {0002-9637},
  journal      = {AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE},
  keyword      = {COUNTERFEIT,STABILITY,IN-VITRO DISSOLUTION,SUB-SAHARAN AFRICA,VIVO BIOAVAILABILITY,ANTIMALARIAL-DRUGS,STORAGE-CONDITIONS,SUBSTANDARD DRUGS,FAKE DRUGS,GLOBAL BURDEN},
  language     = {eng},
  number       = {5},
  pages        = {776--781},
  title        = {Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies},
  url          = {http://dx.doi.org/10.4269/ajtmh.2009.09-0109},
  volume       = {81},
  year         = {2009},
}

Chicago
Twagirumukiza, Marc, An Cosijns, Eveline Pringels, Jean Paul Remon, Chris Vervaet, and Lucas Van Bortel. 2009. “Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies.” American Journal of Tropical Medicine and Hygiene 81 (5): 776–781.
APA
Twagirumukiza, Marc, Cosijns, A., Pringels, E., Remon, J. P., Vervaet, C., & Van Bortel, L. (2009). Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 81(5), 776–781.
Vancouver
1.
Twagirumukiza M, Cosijns A, Pringels E, Remon JP, Vervaet C, Van Bortel L. Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2009;81(5):776–81.
MLA
Twagirumukiza, Marc, An Cosijns, Eveline Pringels, et al. “Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies.” AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 81.5 (2009): 776–781. Print.