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Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension

Christophe Van Steenkiste UGent, Anja Geerts UGent, Eline Vanheule UGent, Hans Van Vlierberghe UGent, Filip De Vos UGent, Kim Olievier UGent, Christophe Casteleyn UGent, Debby Laukens UGent, MARTINE DE VOS UGent and Jean-Marie Stassen, et al. (2009) GASTROENTEROLOGY. 137(6). p.2112-2124
abstract
BACKGROUND & AIMS: Portal hypertension is responsible for the major complications associated with cirrhosis. Angiogenesis has been associated with the pathophysiology of portal hypertension. We investigated the role of placental growth factor (PlGF) and tested the effects of monoclonal antibodies against PlGF (alpha PlGF) in a mouse model of portal hypertension. METHODS: Using a mouse model of prehepatic portal hypertension, we measured PIGF levels in the mesenteric tissue at different time points. We used knockout mice and alpha PlGF to determine the role of PlGF in the splanchnic hyperdynamic system and portosystemic collateral formation, examining its effects before and after portal hypertension was induced. RESULTS: PlGF was significantly up-regulated in the mesenteric tissue of mice with portal hypertension. Compared with wild-type animals, the vascular density in the mesentery was reduced in PlGF knockout hypertensive mice, preventing collateral formation and attenuation of mesenteric artery flow without affecting portal pressure. In the prevention study, alpha PlGF showed similar findings as in the knockout study. in mice with portal hypertension, administration of alpha PlGF resulted in a 32% decrease in portal pressure, compared with mice given immunoglobulin G(1) (control). CONCLUSIONS: Pathologic angiogenesis in the mesenteric tissues of mice with portal hypertension is mediated by PlGF. Blocking PlGF could be an effective strategy for reducing collateral formation and lowering portal pressure; further research into the effects in cirrhosis is warranted.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
GASTROENTEROLOGY
Gastroenterology
volume
137
issue
6
pages
2112 - 2124
publisher
W B SAUNDERS CO-ELSEVIER INC
place of publication
PHILADELPHIA
Web of Science type
Article
Web of Science id
000272539900036
JCR category
GASTROENTEROLOGY & HEPATOLOGY
JCR impact factor
12.899 (2009)
JCR rank
1/64 (2009)
JCR quartile
1 (2009)
ISSN
0016-5085
DOI
10.1053/j.gastro.2009.08.068
language
English
UGent publication?
yes
classification
A1
id
833859
handle
http://hdl.handle.net/1854/LU-833859
date created
2010-01-22 10:45:00
date last changed
2010-01-22 15:42:43
@article{833859,
  abstract     = {BACKGROUND \& AIMS: Portal hypertension is responsible for the major complications associated with cirrhosis. Angiogenesis has been associated with the pathophysiology of portal hypertension. We investigated the role of placental growth factor (PlGF) and tested the effects of monoclonal antibodies against PlGF (alpha PlGF) in a mouse model of portal hypertension. METHODS: Using a mouse model of prehepatic portal hypertension, we measured PIGF levels in the mesenteric tissue at different time points. We used knockout mice and alpha PlGF to determine the role of PlGF in the splanchnic hyperdynamic system and portosystemic collateral formation, examining its effects before and after portal hypertension was induced. RESULTS: PlGF was significantly up-regulated in the mesenteric tissue of mice with portal hypertension. Compared with wild-type animals, the vascular density in the mesentery was reduced in PlGF knockout hypertensive mice, preventing collateral formation and attenuation of mesenteric artery flow without affecting portal pressure. In the prevention study, alpha PlGF showed similar findings as in the knockout study. in mice with portal hypertension, administration of alpha PlGF resulted in a 32\% decrease in portal pressure, compared with mice given immunoglobulin G(1) (control). CONCLUSIONS: Pathologic angiogenesis in the mesenteric tissues of mice with portal hypertension is mediated by PlGF. Blocking PlGF could be an effective strategy for reducing collateral formation and lowering portal pressure; further research into the effects in cirrhosis is warranted.},
  author       = {Van Steenkiste, Christophe and Geerts, Anja and Vanheule, Eline and Van Vlierberghe, Hans and De Vos, Filip and Olievier, Kim and Casteleyn, Christophe and Laukens, Debby and DE VOS, MARTINE and Stassen, Jean-Marie and Carmeliet, Peter and Colle, Isabelle},
  issn         = {0016-5085},
  journal      = {GASTROENTEROLOGY},
  language     = {eng},
  number       = {6},
  pages        = {2112--2124},
  publisher    = {W B SAUNDERS CO-ELSEVIER INC},
  title        = {Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension},
  url          = {http://dx.doi.org/10.1053/j.gastro.2009.08.068},
  volume       = {137},
  year         = {2009},
}

Chicago
Van Steenkiste, Christophe, Anja Geerts, Eline Vanheule, Hans Van Vlierberghe, Filip De Vos, Kim Olievier, Christophe Casteleyn, et al. 2009. “Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension.” Gastroenterology 137 (6): 2112–2124.
APA
Van Steenkiste, C., Geerts, A., Vanheule, E., Van Vlierberghe, H., De Vos, F., Olievier, K., Casteleyn, C., et al. (2009). Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension. GASTROENTEROLOGY, 137(6), 2112–2124.
Vancouver
1.
Van Steenkiste C, Geerts A, Vanheule E, Van Vlierberghe H, De Vos F, Olievier K, et al. Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension. GASTROENTEROLOGY. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC; 2009;137(6):2112–24.
MLA
Van Steenkiste, Christophe, Anja Geerts, Eline Vanheule, et al. “Role of Placental Growth Factor in Mesenteric Neoangiogenesis in a Mouse Model of Portal Hypertension.” GASTROENTEROLOGY 137.6 (2009): 2112–2124. Print.