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Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy

(2009) BRITISH JOURNAL OF OPHTHALMOLOGY. 93(11). p.1539-1545
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Organization
Abstract
Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated. Methods: TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding (> 1 week) retinal detachment (n = 29), fresh (< 1 week) retinal detachment (n = 17), macular holes (n = 20) or diabetic retinopathy (n = 11). Vitreous samples were taken at the start of every vitrectomy procedure. For reference values, cadaver specimens (n = 73) were used. Results: Reference values for vitreous TTR (median 18 mg/l; IQR 4 to 24 mg/l) comprised 2.2% of reference values for vitreous protein levels (median 538 mg/l; IQR 269 to 987 mg/l). Vitreous TTR values of patients were comparable in all disorders. Vitreous TTR values were higher in phakic (median 22.5 mg/l; IQR 10 to 27 mg/l) than in pseudophakic patients (median 12 mg/l; IQR 8 to 19 mg/l; p = 0.06). Postoperative change in visual acuity correlated well with vitreous TTR values found peroperatively (r(s) = 0.408; p = 0.012). Both change in visual acuity and lens status were the only variables which proved to explain the variance of TTR (multiple correlation coefficient: 0.494; phakic status: t = 2.767; p = 0.0084; and change in visual acuity t = 2.924: p = 0.0056). Conclusion: Vitreous fluid concentrations of TTR can be regarded as a biochemical marker for retinal function.
Keywords
SECRETION, RETINOL-BINDING-PROTEIN, PIGMENT EPITHELIUM, MOLECULAR-BIOLOGY, THYROID-HORMONE, RISK-FACTORS, IRBP, CELL, AMYLOIDOSIS, EXPRESSION

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MLA
Van Aken, Elisabeth et al. “Transthyretin Levels in the Vitreous Correlate with Change in Visual Acuity After Vitrectomy.” BRITISH JOURNAL OF OPHTHALMOLOGY 93.11 (2009): 1539–1545. Print.
APA
Van Aken, E., De Letter, E., Veckeneer, M., Derycke, L., van Enschot, T., Geers, I., Delanghe, S., et al. (2009). Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy. BRITISH JOURNAL OF OPHTHALMOLOGY, 93(11), 1539–1545.
Chicago author-date
Van Aken, Elisabeth, Els De Letter, M Veckeneer, Lara Derycke, T van Enschot, I Geers, S Delanghe, and Joris Delanghe. 2009. “Transthyretin Levels in the Vitreous Correlate with Change in Visual Acuity After Vitrectomy.” British Journal of Ophthalmology 93 (11): 1539–1545.
Chicago author-date (all authors)
Van Aken, Elisabeth, Els De Letter, M Veckeneer, Lara Derycke, T van Enschot, I Geers, S Delanghe, and Joris Delanghe. 2009. “Transthyretin Levels in the Vitreous Correlate with Change in Visual Acuity After Vitrectomy.” British Journal of Ophthalmology 93 (11): 1539–1545.
Vancouver
1.
Van Aken E, De Letter E, Veckeneer M, Derycke L, van Enschot T, Geers I, et al. Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy. BRITISH JOURNAL OF OPHTHALMOLOGY. 2009;93(11):1539–45.
IEEE
[1]
E. Van Aken et al., “Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy,” BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 93, no. 11, pp. 1539–1545, 2009.
@article{833773,
  abstract     = {Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated.
Methods: TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding (> 1 week) retinal detachment (n = 29), fresh (< 1 week) retinal detachment (n = 17), macular holes (n = 20) or diabetic retinopathy (n = 11). Vitreous samples were taken at the start of every vitrectomy procedure. For reference values, cadaver specimens (n = 73) were used.
Results: Reference values for vitreous TTR (median 18 mg/l; IQR 4 to 24 mg/l) comprised 2.2% of reference values for vitreous protein levels (median 538 mg/l; IQR 269 to 987 mg/l). Vitreous TTR values of patients were comparable in all disorders. Vitreous TTR values were higher in phakic (median 22.5 mg/l; IQR 10 to 27 mg/l) than in pseudophakic patients (median 12 mg/l; IQR 8 to 19 mg/l; p = 0.06). Postoperative change in visual acuity correlated well with vitreous TTR values found peroperatively (r(s) = 0.408; p = 0.012). Both change in visual acuity and lens status were the only variables which proved to explain the variance of TTR (multiple correlation coefficient: 0.494; phakic status: t = 2.767; p = 0.0084; and change in visual acuity t = 2.924: p = 0.0056).
Conclusion: Vitreous fluid concentrations of TTR can be regarded as a biochemical marker for retinal function.},
  author       = {Van Aken, Elisabeth and De Letter, Els and Veckeneer, M and Derycke, Lara and van Enschot, T and Geers, I and Delanghe, S and Delanghe, Joris},
  issn         = {0007-1161},
  journal      = {BRITISH JOURNAL OF OPHTHALMOLOGY},
  keywords     = {SECRETION,RETINOL-BINDING-PROTEIN,PIGMENT EPITHELIUM,MOLECULAR-BIOLOGY,THYROID-HORMONE,RISK-FACTORS,IRBP,CELL,AMYLOIDOSIS,EXPRESSION},
  language     = {eng},
  number       = {11},
  pages        = {1539--1545},
  title        = {Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy},
  url          = {http://dx.doi.org/10.1136/bjo.2009.158048},
  volume       = {93},
  year         = {2009},
}

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