Ghent University Academic Bibliography

Advanced

Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy

Elisabeth Van Aken UGent, Els De Letter UGent, M Veckeneer, LARA DERYCKE UGent, T van Enschot, I Geers, S Delanghe and Joris Delanghe UGent (2009) BRITISH JOURNAL OF OPHTHALMOLOGY. 93(11). p.1539-1545
abstract
Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated. Methods: TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding (> 1 week) retinal detachment (n = 29), fresh (< 1 week) retinal detachment (n = 17), macular holes (n = 20) or diabetic retinopathy (n = 11). Vitreous samples were taken at the start of every vitrectomy procedure. For reference values, cadaver specimens (n = 73) were used. Results: Reference values for vitreous TTR (median 18 mg/l; IQR 4 to 24 mg/l) comprised 2.2% of reference values for vitreous protein levels (median 538 mg/l; IQR 269 to 987 mg/l). Vitreous TTR values of patients were comparable in all disorders. Vitreous TTR values were higher in phakic (median 22.5 mg/l; IQR 10 to 27 mg/l) than in pseudophakic patients (median 12 mg/l; IQR 8 to 19 mg/l; p = 0.06). Postoperative change in visual acuity correlated well with vitreous TTR values found peroperatively (r(s) = 0.408; p = 0.012). Both change in visual acuity and lens status were the only variables which proved to explain the variance of TTR (multiple correlation coefficient: 0.494; phakic status: t = 2.767; p = 0.0084; and change in visual acuity t = 2.924: p = 0.0056). Conclusion: Vitreous fluid concentrations of TTR can be regarded as a biochemical marker for retinal function.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SECRETION, RETINOL-BINDING-PROTEIN, PIGMENT EPITHELIUM, MOLECULAR-BIOLOGY, THYROID-HORMONE, RISK-FACTORS, IRBP, CELL, AMYLOIDOSIS, EXPRESSION
journal title
BRITISH JOURNAL OF OPHTHALMOLOGY
Br. J. Ophthalmol.
volume
93
issue
11
pages
1539 - 1545
Web of Science type
Article
Web of Science id
000271091900027
JCR category
OPHTHALMOLOGY
JCR impact factor
2.917 (2009)
JCR rank
9/49 (2009)
JCR quartile
1 (2009)
ISSN
0007-1161
DOI
10.1136/bjo.2009.158048
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
833773
handle
http://hdl.handle.net/1854/LU-833773
date created
2010-01-22 10:25:34
date last changed
2015-06-17 11:20:29
@article{833773,
  abstract     = {Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated.
Methods: TTR was measured using immunonephelometry in a group of patients (n = 77) in longstanding ({\textrangle} 1 week) retinal detachment (n = 29), fresh ({\textlangle} 1 week) retinal detachment (n = 17), macular holes (n = 20) or diabetic retinopathy (n = 11). Vitreous samples were taken at the start of every vitrectomy procedure. For reference values, cadaver specimens (n = 73) were used.
Results: Reference values for vitreous TTR (median 18 mg/l; IQR 4 to 24 mg/l) comprised 2.2\% of reference values for vitreous protein levels (median 538 mg/l; IQR 269 to 987 mg/l). Vitreous TTR values of patients were comparable in all disorders. Vitreous TTR values were higher in phakic (median 22.5 mg/l; IQR 10 to 27 mg/l) than in pseudophakic patients (median 12 mg/l; IQR 8 to 19 mg/l; p = 0.06). Postoperative change in visual acuity correlated well with vitreous TTR values found peroperatively (r(s) = 0.408; p = 0.012). Both change in visual acuity and lens status were the only variables which proved to explain the variance of TTR (multiple correlation coefficient: 0.494; phakic status: t = 2.767; p = 0.0084; and change in visual acuity t = 2.924: p = 0.0056).
Conclusion: Vitreous fluid concentrations of TTR can be regarded as a biochemical marker for retinal function.},
  author       = {Van Aken, Elisabeth and De Letter, Els and Veckeneer, M and DERYCKE, LARA and van Enschot, T and Geers, I and Delanghe, S and Delanghe, Joris},
  issn         = {0007-1161},
  journal      = {BRITISH JOURNAL OF OPHTHALMOLOGY},
  keyword      = {SECRETION,RETINOL-BINDING-PROTEIN,PIGMENT EPITHELIUM,MOLECULAR-BIOLOGY,THYROID-HORMONE,RISK-FACTORS,IRBP,CELL,AMYLOIDOSIS,EXPRESSION},
  language     = {eng},
  number       = {11},
  pages        = {1539--1545},
  title        = {Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy},
  url          = {http://dx.doi.org/10.1136/bjo.2009.158048},
  volume       = {93},
  year         = {2009},
}

Chicago
Van Aken, Elisabeth, Els De Letter, M Veckeneer, LARA DERYCKE, T van Enschot, I Geers, S Delanghe, and Joris Delanghe. 2009. “Transthyretin Levels in the Vitreous Correlate with Change in Visual Acuity After Vitrectomy.” British Journal of Ophthalmology 93 (11): 1539–1545.
APA
Van Aken, Elisabeth, De Letter, E., Veckeneer, M., DERYCKE, L., van Enschot, T., Geers, I., Delanghe, S., et al. (2009). Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy. BRITISH JOURNAL OF OPHTHALMOLOGY, 93(11), 1539–1545.
Vancouver
1.
Van Aken E, De Letter E, Veckeneer M, DERYCKE L, van Enschot T, Geers I, et al. Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy. BRITISH JOURNAL OF OPHTHALMOLOGY. 2009;93(11):1539–45.
MLA
Van Aken, Elisabeth, Els De Letter, M Veckeneer, et al. “Transthyretin Levels in the Vitreous Correlate with Change in Visual Acuity After Vitrectomy.” BRITISH JOURNAL OF OPHTHALMOLOGY 93.11 (2009): 1539–1545. Print.