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Studying the function of dendritic cells in mouse models of asthma

Philippe Pouliot UGent, Monique Willart, Hamida Hammad UGent and Bart Lambrecht UGent (2010) Dendritic cell protocols. In Methods Molecular Biology 595. p.331-349
abstract
Dendritic cells (DCs) are known to play a crucial role in the induction of allergic asthma in mouse models. Their antigen presentation capacity, linked to their capacity to prime naïve T cells and polarize them towards a Th1, Th2, Th17 or Treg profile, allows them to efficiently initiate an immune response to allergens. Airway dendritic cells also play a crucial role in the local restimulation of circulating effector T cells upon allergen challenge. Given their important implication in pathogenesis of asthma in mice models, the study of environmental and pharmacologic effects on DCs function is now a blooming field. There is therefore a critical need for a stable, yet flexible animal model to investigate the effects of various environmental factors (endotoxins, pollutants, etc.) or pharmacologic molecules on DCs and subsequently on their role in asthma pathogenesis. This chapter presents an approach using a reliable animal model of asthma that has the advantage to allow interventions on DCs before their use to induce allergic asthma. We also cover some of the endpoint techniques used to assess asthma and the immune reactions involved in its pathogenesis.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
keyword
methods, mouse models, dendritic cells, asthma
book title
Dendritic cell protocols
Methods Mol Biol
series title
Methods Molecular Biology
volume
595
edition
2
pages
331 - 349
publisher
Humana Press
ISBN
978-1-60761-420-3
DOI
10.1007/978-1-60761-421-0_22
language
English
UGent publication?
yes
classification
B2
copyright statement
I have transferred the copyright for this publication to the publisher
id
833668
handle
http://hdl.handle.net/1854/LU-833668
date created
2010-01-22 09:44:05
date last changed
2016-12-19 15:45:33
@incollection{833668,
  abstract     = {Dendritic cells (DCs) are known to play a crucial role in the induction of allergic asthma in mouse models. Their antigen presentation capacity, linked to their capacity to prime na{\"i}ve T cells and polarize them towards a Th1, Th2, Th17 or Treg profile, allows them to efficiently initiate an immune response to allergens. Airway dendritic cells also play a crucial role in the local restimulation of circulating effector T cells upon allergen challenge. Given their important implication in pathogenesis of asthma in mice models, the study of environmental and pharmacologic effects on DCs function is now a blooming field. There is therefore a critical need for a stable, yet flexible animal model to investigate the effects of various environmental factors (endotoxins, pollutants, etc.) or pharmacologic molecules on DCs and subsequently on their role in asthma pathogenesis. This chapter presents an approach using a reliable animal model of asthma that has the advantage to allow interventions on DCs before their use to induce allergic asthma. We also cover some of the endpoint techniques used to assess asthma and the immune reactions involved in its pathogenesis.},
  author       = {Pouliot, Philippe and Willart, Monique and Hammad, Hamida and Lambrecht, Bart},
  booktitle    = {Dendritic cell protocols},
  isbn         = {978-1-60761-420-3},
  keyword      = {methods,mouse models,dendritic cells,asthma},
  language     = {eng},
  pages        = {331--349},
  publisher    = {Humana Press},
  series       = {Methods Molecular Biology},
  title        = {Studying the function of dendritic cells in mouse models of asthma},
  url          = {http://dx.doi.org/10.1007/978-1-60761-421-0\_22},
  volume       = {595},
  year         = {2010},
}

Chicago
Pouliot, Philippe, Monique Willart, Hamida Hammad, and Bart Lambrecht. 2010. “Studying the Function of Dendritic Cells in Mouse Models of Asthma.” In Dendritic Cell Protocols, 595:331–349. 2nd ed. Humana Press.
APA
Pouliot, P., Willart, M., Hammad, H., & Lambrecht, B. (2010). Studying the function of dendritic cells in mouse models of asthma. Dendritic cell protocols (2nd ed., Vol. 595, pp. 331–349). Humana Press.
Vancouver
1.
Pouliot P, Willart M, Hammad H, Lambrecht B. Studying the function of dendritic cells in mouse models of asthma. Dendritic cell protocols. 2nd ed. Humana Press; 2010. p. 331–49.
MLA
Pouliot, Philippe, Monique Willart, Hamida Hammad, et al. “Studying the Function of Dendritic Cells in Mouse Models of Asthma.” Dendritic Cell Protocols. 2nd ed. Vol. 595. Humana Press, 2010. 331–349. Print.