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Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures

Veerle De Herdt (UGent) , Jan De Waele (UGent) , Robrecht Raedt (UGent) , Tine Wyckhuys (UGent) , RIEM EL TAHRY (UGent) , Kristl Vonck (UGent) , Wytse Wadman (UGent) and Paul Boon (UGent)
(2010) ACTA NEUROLOGICA SCANDINAVICA. 121(4). p.271-276
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Abstract
Objective – The precise mechanism of action of vagus nerve stimulation (VNS) in suppressing epileptic seizures remains to be elucidated. This study investigates whether VNS modulates cortical excitability by determining the threshold for provoking focal motor seizures by cortical electrical stimulation before and after VNS. Material and methods – Male Wistar rats (n = 8) were implanted with a cuff-electrode around the left vagus nerve and with stimulation electrodes placed bilaterally on the rat motor cortex. Motor seizure threshold (MST) was assessed for each rat before and immediately after 1 h of VNS with standard stimulation parameters, during two to three sessions on different days. Results – An overall significant increase of the MST was observed following 1 h of VNS compared to the baseline value (1420 μA and 1072 μA, respectively; P < 0.01). The effect was reproducible over time with an increase in MST in each experimental session. Conclusions – VNS significantly increases the MST in a cortical stimulation model for motor seizures. These data indicate that VNS is capable of modulating cortical excitability.
Keywords
LOCUS-COERULEUS, INCREASES, RAT, NOREPINEPHRINE, ACTIVATION, THERAPY, VAGAL-STIMULATION, REFRACTORY EPILEPSY, DIRECT CORTICAL STIMULATION, INTERICTAL EPILEPTIFORM DISCHARGES, vagus nerve stimulation, seizure threshold, cortical excitability, cortical stimulation

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Chicago
De Herdt, Veerle, Jan De Waele, Robrecht Raedt, Tine Wyckhuys, RIEM EL TAHRY, Kristl Vonck, Wytse Wadman, and Paul Boon. 2010. “Modulation of Seizure Threshold by Vagus Nerve Stimulation in an Animal Model for Motor Seizures.” Acta Neurologica Scandinavica 121 (4): 271–276.
APA
De Herdt, V., De Waele, J., Raedt, R., Wyckhuys, T., EL TAHRY, R., Vonck, K., Wadman, W., et al. (2010). Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures. ACTA NEUROLOGICA SCANDINAVICA, 121(4), 271–276.
Vancouver
1.
De Herdt V, De Waele J, Raedt R, Wyckhuys T, EL TAHRY R, Vonck K, et al. Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures. ACTA NEUROLOGICA SCANDINAVICA. 2010;121(4):271–6.
MLA
De Herdt, Veerle, Jan De Waele, Robrecht Raedt, et al. “Modulation of Seizure Threshold by Vagus Nerve Stimulation in an Animal Model for Motor Seizures.” ACTA NEUROLOGICA SCANDINAVICA 121.4 (2010): 271–276. Print.
@article{833453,
  abstract     = {Objective -- The precise mechanism of action of vagus nerve stimulation (VNS) in suppressing epileptic seizures remains to be elucidated. This study investigates whether VNS modulates cortical excitability by determining the threshold for provoking focal motor seizures by cortical electrical stimulation before and after VNS.
Material and methods -- Male Wistar rats (n = 8) were implanted with a cuff-electrode around the left vagus nerve and with stimulation electrodes placed bilaterally on the rat motor cortex. Motor seizure threshold (MST) was assessed for each rat before and immediately after 1 h of VNS with standard stimulation parameters, during two to three sessions on different days.
Results -- An overall significant increase of the MST was observed following 1 h of VNS compared to the baseline value (1420 \ensuremath{\mu}A and 1072 \ensuremath{\mu}A, respectively; P {\textlangle} 0.01). The effect was reproducible over time with an increase in MST in each experimental session.
Conclusions -- VNS significantly increases the MST in a cortical stimulation model for motor seizures. These data indicate that VNS is capable of modulating cortical excitability.},
  author       = {De Herdt, Veerle and De Waele, Jan and Raedt, Robrecht and Wyckhuys, Tine and EL TAHRY, RIEM and Vonck, Kristl and Wadman, Wytse and Boon, Paul},
  issn         = {0001-6314},
  journal      = {ACTA NEUROLOGICA SCANDINAVICA},
  language     = {eng},
  number       = {4},
  pages        = {271--276},
  title        = {Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures},
  url          = {http://dx.doi.org/10.1111/j.1600-0404.2009.01223.x},
  volume       = {121},
  year         = {2010},
}

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