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Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures

Veerle De Herdt UGent, Jan De Waele UGent, Robrecht Raedt UGent, Tine Wyckhuys UGent, RIEM EL TAHRY UGent, Kristl Vonck UGent, Wytse Wadman UGent and Paul Boon UGent (2010) ACTA NEUROLOGICA SCANDINAVICA. 121(4). p.271-276
abstract
Objective – The precise mechanism of action of vagus nerve stimulation (VNS) in suppressing epileptic seizures remains to be elucidated. This study investigates whether VNS modulates cortical excitability by determining the threshold for provoking focal motor seizures by cortical electrical stimulation before and after VNS. Material and methods – Male Wistar rats (n = 8) were implanted with a cuff-electrode around the left vagus nerve and with stimulation electrodes placed bilaterally on the rat motor cortex. Motor seizure threshold (MST) was assessed for each rat before and immediately after 1 h of VNS with standard stimulation parameters, during two to three sessions on different days. Results – An overall significant increase of the MST was observed following 1 h of VNS compared to the baseline value (1420 μA and 1072 μA, respectively; P < 0.01). The effect was reproducible over time with an increase in MST in each experimental session. Conclusions – VNS significantly increases the MST in a cortical stimulation model for motor seizures. These data indicate that VNS is capable of modulating cortical excitability.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
LOCUS-COERULEUS, INCREASES, RAT, NOREPINEPHRINE, ACTIVATION, THERAPY, VAGAL-STIMULATION, REFRACTORY EPILEPSY, DIRECT CORTICAL STIMULATION, INTERICTAL EPILEPTIFORM DISCHARGES, vagus nerve stimulation, seizure threshold, cortical excitability, cortical stimulation
journal title
ACTA NEUROLOGICA SCANDINAVICA
Acta Neurol. Scand.
volume
121
issue
4
pages
271 - 276
Web of Science type
Article
Web of Science id
000275216400009
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.153 (2010)
JCR rank
86/185 (2010)
JCR quartile
2 (2010)
ISSN
0001-6314
DOI
10.1111/j.1600-0404.2009.01223.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
833453
handle
http://hdl.handle.net/1854/LU-833453
date created
2010-01-22 09:12:14
date last changed
2010-04-27 08:54:08
@article{833453,
  abstract     = {Objective -- The precise mechanism of action of vagus nerve stimulation (VNS) in suppressing epileptic seizures remains to be elucidated. This study investigates whether VNS modulates cortical excitability by determining the threshold for provoking focal motor seizures by cortical electrical stimulation before and after VNS.
Material and methods -- Male Wistar rats (n = 8) were implanted with a cuff-electrode around the left vagus nerve and with stimulation electrodes placed bilaterally on the rat motor cortex. Motor seizure threshold (MST) was assessed for each rat before and immediately after 1 h of VNS with standard stimulation parameters, during two to three sessions on different days.
Results -- An overall significant increase of the MST was observed following 1 h of VNS compared to the baseline value (1420 \ensuremath{\mu}A and 1072 \ensuremath{\mu}A, respectively; P {\textlangle} 0.01). The effect was reproducible over time with an increase in MST in each experimental session.
Conclusions -- VNS significantly increases the MST in a cortical stimulation model for motor seizures. These data indicate that VNS is capable of modulating cortical excitability.},
  author       = {De Herdt, Veerle and De Waele, Jan and Raedt, Robrecht and Wyckhuys, Tine and EL TAHRY, RIEM and Vonck, Kristl and Wadman, Wytse and Boon, Paul},
  issn         = {0001-6314},
  journal      = {ACTA NEUROLOGICA SCANDINAVICA},
  keyword      = {LOCUS-COERULEUS,INCREASES,RAT,NOREPINEPHRINE,ACTIVATION,THERAPY,VAGAL-STIMULATION,REFRACTORY EPILEPSY,DIRECT CORTICAL STIMULATION,INTERICTAL EPILEPTIFORM DISCHARGES,vagus nerve stimulation,seizure threshold,cortical excitability,cortical stimulation},
  language     = {eng},
  number       = {4},
  pages        = {271--276},
  title        = {Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures},
  url          = {http://dx.doi.org/10.1111/j.1600-0404.2009.01223.x},
  volume       = {121},
  year         = {2010},
}

Chicago
DE HERDT, VEERLE, Jan De Waele, Robrecht Raedt, Tine Wyckhuys, RIEM EL TAHRY, Kristl Vonck, Wytse Wadman, and Paul Boon. 2010. “Modulation of Seizure Threshold by Vagus Nerve Stimulation in an Animal Model for Motor Seizures.” Acta Neurologica Scandinavica 121 (4): 271–276.
APA
DE HERDT, V., De Waele, J., Raedt, R., Wyckhuys, T., EL TAHRY, R., Vonck, K., Wadman, W., et al. (2010). Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures. ACTA NEUROLOGICA SCANDINAVICA, 121(4), 271–276.
Vancouver
1.
DE HERDT V, De Waele J, Raedt R, Wyckhuys T, EL TAHRY R, Vonck K, et al. Modulation of seizure threshold by vagus nerve stimulation in an animal model for motor seizures. ACTA NEUROLOGICA SCANDINAVICA. 2010;121(4):271–6.
MLA
DE HERDT, VEERLE, Jan De Waele, Robrecht Raedt, et al. “Modulation of Seizure Threshold by Vagus Nerve Stimulation in an Animal Model for Motor Seizures.” ACTA NEUROLOGICA SCANDINAVICA 121.4 (2010): 271–276. Print.