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Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturation

Bruno Lapauw (UGent) , Youri Taes (UGent) , Stefan Goemaere (UGent) , Kaatje Toye (UGent) , Hans-Georg Zmierczak (UGent) and Jean Kaufman (UGent)
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Abstract
Context: Pathophysiology of deficient bone mass acquisition in male idiopathic osteoporosis (IO) remains poorly understood. Objective: Our objective was to investigate volumetric and geometric parameters of the appendicular skeleton, biochemical markers, and anthropometrics in men with IO. Design, Setting, and Participants: Our cross-sectional study included 107 men diagnosed with idiopathic low bone mass, 23 of their adult sons, and 130 age-matched controls. Main Outcome Measures: Body composition and areal bone parameters (dual-energy x-ray absorptiometry) and volumetric and geometric parameters of radius and tibia (peripheral quantitative computed tomography) were assessed. Serum levels of testosterone, estradiol (E-2), and SHBG, and bone turnover markers were measured using immunoassays. Free hormone fractions were calculated. Results: Men with idiopathic low bone mass had lower weight (-9.6%), truncal height (-3.3%), and upper/lower body segment ratio (-2.7%; all P < 0.001) and presented at the radius and tibia lower trabecular (-19.0 and -23.6%, respectively; both P < 0.001) and cortical volumetric bone mineral density (vBMD) (-2.4 and -1.7%; both P < 0.001) and smaller cortical areas (-9.7 and -13.6%; both P < 0.001) and thicknesses (-13.5 and -14.5%, both P < 0.001) due to larger endosteal circumferences (-11.8 and -7.4%, both P < 0.001) than controls. Furthermore, (free) E-2 was lower and SHBG higher (both P < 0.01). Their sons had lower trabecular vBMD (-10.3%, P = 0.036) and a thinner cortex (-8.3%, P = 0.024) at the radius. Conclusion: Bonemass deficits in men with idiopathic low bone mass involve trabecular and cortical bone, resulting from lower vBMD and smaller cortical bone cross-sectional areas and thicknesses. A similar bone phenotype is present in at least part of their sons. The lower E-2, together with characteristics as lower upper/lower body segment ratio, larger endosteal circumferences and lower vBMD, may indicate an estrogen-related factor in the pathogenesis of male IO.
Keywords
VERTEBRAL FRACTURE, BONE-MINERAL DENSITY, PHYSICAL-ACTIVITY, FREE TESTOSTERONE, TURNOVER MARKERS, ESTRADIOL LEVELS, SERUM ESTRADIOL, FEMORAL-NECK, SEX STEROIDS, HORMONE-BINDING GLOBULIN

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Chicago
Lapauw, Bruno, Youri Taes, Stefan Goemaere, Kaatje Toye, Hans-Georg Zmierczak, and Jean Kaufman. 2009. “Anthropometric and Skeletal Phenotype in Men with Idiopathic Osteoporosis and Their Sons Is Consistent with Deficient Estrogen Action During Maturation.” Journal of Clinical Endocrinology & Metabolism 94 (11): 4300–4308.
APA
Lapauw, B., Taes, Y., Goemaere, S., Toye, K., Zmierczak, H.-G., & Kaufman, J. (2009). Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturation. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 94(11), 4300–4308.
Vancouver
1.
Lapauw B, Taes Y, Goemaere S, Toye K, Zmierczak H-G, Kaufman J. Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturation. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2009;94(11):4300–8.
MLA
Lapauw, Bruno, Youri Taes, Stefan Goemaere, et al. “Anthropometric and Skeletal Phenotype in Men with Idiopathic Osteoporosis and Their Sons Is Consistent with Deficient Estrogen Action During Maturation.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 94.11 (2009): 4300–4308. Print.
@article{829490,
  abstract     = {Context: Pathophysiology of deficient bone mass acquisition in male idiopathic osteoporosis (IO) remains poorly understood.
Objective: Our objective was to investigate volumetric and geometric parameters of the appendicular skeleton, biochemical markers, and anthropometrics in men with IO.
Design, Setting, and Participants: Our cross-sectional study included 107 men diagnosed with idiopathic low bone mass, 23 of their adult sons, and 130 age-matched controls.
Main Outcome Measures: Body composition and areal bone parameters (dual-energy x-ray absorptiometry) and volumetric and geometric parameters of radius and tibia (peripheral quantitative computed tomography) were assessed. Serum levels of testosterone, estradiol (E-2), and SHBG, and bone turnover markers were measured using immunoassays. Free hormone fractions were calculated.
Results: Men with idiopathic low bone mass had lower weight (-9.6\%), truncal height (-3.3\%), and upper/lower body segment ratio (-2.7\%; all P {\textlangle} 0.001) and presented at the radius and tibia lower trabecular (-19.0 and -23.6\%, respectively; both P {\textlangle} 0.001) and cortical volumetric bone mineral density (vBMD) (-2.4 and -1.7\%; both P {\textlangle} 0.001) and smaller cortical areas (-9.7 and -13.6\%; both P {\textlangle} 0.001) and thicknesses (-13.5 and -14.5\%, both P {\textlangle} 0.001) due to larger endosteal circumferences (-11.8 and -7.4\%, both P {\textlangle} 0.001) than controls. Furthermore, (free) E-2 was lower and SHBG higher (both P {\textlangle} 0.01). Their sons had lower trabecular vBMD (-10.3\%, P = 0.036) and a thinner cortex (-8.3\%, P = 0.024) at the radius.
Conclusion: Bonemass deficits in men with idiopathic low bone mass involve trabecular and cortical bone, resulting from lower vBMD and smaller cortical bone cross-sectional areas and thicknesses. A similar bone phenotype is present in at least part of their sons. The lower E-2, together with characteristics as lower upper/lower body segment ratio, larger endosteal circumferences and lower vBMD, may indicate an estrogen-related factor in the pathogenesis of male IO.},
  author       = {Lapauw, Bruno and Taes, Youri and Goemaere, Stefan and Toye, Kaatje and Zmierczak, Hans-Georg and Kaufman, Jean},
  issn         = {0021-972X},
  journal      = {JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM},
  keyword      = {VERTEBRAL FRACTURE,BONE-MINERAL DENSITY,PHYSICAL-ACTIVITY,FREE TESTOSTERONE,TURNOVER MARKERS,ESTRADIOL LEVELS,SERUM ESTRADIOL,FEMORAL-NECK,SEX STEROIDS,HORMONE-BINDING GLOBULIN},
  language     = {eng},
  number       = {11},
  pages        = {4300--4308},
  title        = {Anthropometric and skeletal phenotype in men with idiopathic osteoporosis and their sons is consistent with deficient estrogen action during maturation},
  url          = {http://dx.doi.org/10.1210/jc.2009-0568},
  volume       = {94},
  year         = {2009},
}

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