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Ischemic stroke and hyperhomocysteinemia: truth or myth?

ANNELIES TERWECOREN (UGent) , ELKE STEEN (UGent) , Dominique Benoit (UGent) , Paul Boon (UGent) and Dimitri Hemelsoet (UGent)
(2009) ACTA NEUROLOGICA BELGICA. 109(3). p.181-188
Author
Organization
Abstract
Hyperhomocysteinemia is generally acknowledged as a treatable risk factor for atherotrombotic diseases, but a causal relationship between both is not Yet definitively established. Hyperhomocysteinemia originates from a deviation in the methionine-homocysteine metabolism including disturbances of enzymes, vitamin deficiencies and different other factors. Observational studies, genetic polymorphism studies and several meta-analyses implicate already a causal relation between homocysteine and cerebrovascular diseases. It is useful to determine homocysteine levels for stroke who present no clue for vascular disease and thrombosis, who have an ischemic stroke at a young age and who have a family history of premature atherosclerosis. Because of the low cost and safety of the therapy, the American Heart and Stroke Association advises to treat patients with a stroke and hyperhomocysteinemia daily with 0,4 mg folic acid, 2,4 mu g vitamin 1312 and 1, 7 mg vitamin B6. A significant benefit in secondary prevention is not yet proven. The results of larger follow-up trials have to be published.
Keywords
VITAMIN INTERVENTION, EFFICACY ANALYSIS, PREVENTION TRIAL, CARDIOVASCULAR EVENTS, MYOCARDIAL-INFARCTION, RANDOMIZED CONTROLLED-TRIAL, vitamin therapy, secondary prevention, ischemic stroke, methionine-homocysteine metabolism, Hyperhomocysteinemia, RISK, FOLIC-ACID, HOMOCYSTEINE, DISEASE

Citation

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Chicago
TERWECOREN, ANNELIES, ELKE STEEN, Dominique Benoit, Paul Boon, and DIMITRI HEMELSOET. 2009. “Ischemic Stroke and Hyperhomocysteinemia: Truth or Myth?” Acta Neurologica Belgica 109 (3): 181–188.
APA
TERWECOREN, A., STEEN, E., Benoit, D., Boon, P., & HEMELSOET, D. (2009). Ischemic stroke and hyperhomocysteinemia: truth or myth? ACTA NEUROLOGICA BELGICA, 109(3), 181–188.
Vancouver
1.
TERWECOREN A, STEEN E, Benoit D, Boon P, HEMELSOET D. Ischemic stroke and hyperhomocysteinemia: truth or myth? ACTA NEUROLOGICA BELGICA. 2009;109(3):181–8.
MLA
TERWECOREN, ANNELIES, ELKE STEEN, Dominique Benoit, et al. “Ischemic Stroke and Hyperhomocysteinemia: Truth or Myth?” ACTA NEUROLOGICA BELGICA 109.3 (2009): 181–188. Print.
@article{829160,
  abstract     = {Hyperhomocysteinemia is generally acknowledged as a treatable risk factor for atherotrombotic diseases, but a causal relationship between both is not Yet definitively established. Hyperhomocysteinemia originates from a deviation in the methionine-homocysteine metabolism including disturbances of enzymes, vitamin deficiencies and different other factors. Observational studies, genetic polymorphism studies and several meta-analyses implicate already a causal relation between homocysteine and cerebrovascular diseases.
It is useful to determine homocysteine levels for stroke who present no clue for vascular disease and thrombosis, who have an ischemic stroke at a young age and who have a family history of premature atherosclerosis. Because of the low cost and safety of the therapy, the American Heart and Stroke Association advises to treat patients with a stroke and hyperhomocysteinemia daily with 0,4 mg folic acid, 2,4 mu g vitamin 1312 and 1, 7 mg vitamin B6. A significant benefit in secondary prevention is not yet proven. The results of larger follow-up trials have to be published.},
  author       = {TERWECOREN, ANNELIES and STEEN, ELKE and Benoit, Dominique and Boon, Paul and Hemelsoet, Dimitri},
  issn         = {0300-9009},
  journal      = {ACTA NEUROLOGICA BELGICA},
  keyword      = {VITAMIN INTERVENTION,EFFICACY ANALYSIS,PREVENTION TRIAL,CARDIOVASCULAR EVENTS,MYOCARDIAL-INFARCTION,RANDOMIZED CONTROLLED-TRIAL,vitamin therapy,secondary prevention,ischemic stroke,methionine-homocysteine metabolism,Hyperhomocysteinemia,RISK,FOLIC-ACID,HOMOCYSTEINE,DISEASE},
  language     = {eng},
  number       = {3},
  pages        = {181--188},
  title        = {Ischemic stroke and hyperhomocysteinemia: truth or myth?},
  volume       = {109},
  year         = {2009},
}

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