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In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics

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Abstract
An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.
Keywords
silicone encapsulation, gold, gold conductor tracks, 2-D spring pattern, elastic interconnection technology, biocompatible silicone elastomer, in vitro cytotoxicity extraction test, ISO 10 993-1 guidelines, conducting materials, biomedical electronics, biomedical materials, short-term implantable electronics, flexible electronic circuit islands, polymers, prosthetics, integrated circuit interconnections

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Chicago
Brosteaux, Dominique, Evi Lippens, Maria Cornelissen, Etienne Schacht, Riccardo Carta, Philippe Jourand, Robert Puers, et al. 2009. “In Vitro Cytotoxicity Testing and the Application of Elastic Interconnection Technology for Short-term Implantable Electronics.” In EMBC : 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-20, 4880–4883. New York, NY, USA: IEEE.
APA
Brosteaux, D., Lippens, E., Cornelissen, M., Schacht, E., Carta, R., Jourand, P., Puers, R., et al. (2009). In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics. EMBC : 2009 annual international conference of the IEEE Engineering in Medicine and Biology Society, vols 1-20 (pp. 4880–4883). Presented at the 2009 31st Annual international conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2009), New York, NY, USA: IEEE.
Vancouver
1.
Brosteaux D, Lippens E, Cornelissen M, Schacht E, Carta R, Jourand P, et al. In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics. EMBC : 2009 annual international conference of the IEEE Engineering in Medicine and Biology Society, vols 1-20. New York, NY, USA: IEEE; 2009. p. 4880–3.
MLA
Brosteaux, Dominique et al. “In Vitro Cytotoxicity Testing and the Application of Elastic Interconnection Technology for Short-term Implantable Electronics.” EMBC : 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-20. New York, NY, USA: IEEE, 2009. 4880–4883. Print.
@inproceedings{828986,
  abstract     = {An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.},
  author       = {Brosteaux, Dominique and Lippens, Evi and Cornelissen, Maria and Schacht, Etienne and Carta, Riccardo and Jourand, Philippe and Puers, Robert and Axisa, Fabrice and Vervust, Thomas and Bossuyt, Frederick and Vanfleteren, Jan},
  booktitle    = {EMBC : 2009 annual international conference of the IEEE Engineering in Medicine and Biology Society, vols 1-20},
  isbn         = {9781424432950},
  keywords     = {silicone encapsulation,gold,gold conductor tracks,2-D spring pattern,elastic interconnection technology,biocompatible silicone elastomer,in vitro cytotoxicity extraction test,ISO 10 993-1 guidelines,conducting materials,biomedical electronics,biomedical materials,short-term implantable electronics,flexible electronic circuit islands,polymers,prosthetics,integrated circuit interconnections},
  language     = {eng},
  location     = {Minneapolis, MN, USA},
  pages        = {4880--4883},
  publisher    = {IEEE},
  title        = {In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics},
  url          = {http://dx.doi.org/10.1109/IEMBS.2009.5332457},
  year         = {2009},
}

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