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The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: the domestic cat (Felis catus)

Adronie Verbrugghe UGent, Myriam Hesta UGent, Stephanie Van Weyenberg UGent, Georgios Papadopoulos UGent, Kris Gommeren UGent, Sylvie Daminet UGent, Tim Bosmans UGent, Ingeborgh Polis UGent, Johan Buyse and Geert Janssens UGent (2010) BRITISH JOURNAL OF NUTRITION. 104(2). p.214-221
abstract
The present study assessed the effect of separate reduction of each enemy-delivering nutrient - protein, fat and carbohydrate - on glucose tolerance and insulin response in a strict carnivore: the domestic cat (Felis cants). Three isoenergetic, home-made diets with the following energetic distribution, low protein (LP): protein 28 % of metabolisable energy; fat 43 %; nitrogen-free extract 29%; low fat: 47, 27 and 25 %; low carbohydrate (LC): 45, 48 and 7 %, were tested in a 3 x 3 Latin square design. Nine healthy normal-weight cats were randomly assigned to each of the diets in a random order at intervals of 3 weeks. At the end of each testing period, intravenous glucose tolerance tests were performed. Plasma glucose concentrations and area under the glucose curve showed no differences. Area under the insulin curve was lower when cats were fed the LP diet, and the second insulin peak tended to be delayed when the LC diet was fed. In contrast to other studies, in which energy sources were elevated instead of being reduced, the present trial contradicts the often suggested negative impact of carbohydrates on insulin sensitivity in carnivores, and shows that reducing the dietary carbohydrate content below common amounts for commercial foods evokes an insulin-resistant state, which can be explained by the cats' strict carnivorous nature. It even points to a negative effect of protein on insulin sensitivity, a finding that corresponds with the highly gluconeogenic nature of amino acids in strict carnivores.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Carnivores, Carbohydrates, Cats, Energy sources, Insulin resistance, LOW-CARBOHYDRATE DIET, CLINICALLY NORMAL CATS, HIGH-FAT DIET, DIABETES-MELLITUS, REFERENCE VALUES, OVERWEIGHT CATS, NORMAL-WEIGHT, RISK-FACTORS, HIGH-PROTEIN, BODY-WEIGHT
journal title
BRITISH JOURNAL OF NUTRITION
Br. J. Nutr.
volume
104
issue
2
pages
214 - 221
Web of Science type
Article
Web of Science id
000280448900009
JCR category
NUTRITION & DIETETICS
JCR impact factor
3.072 (2010)
JCR rank
19/70 (2010)
JCR quartile
2 (2010)
ISSN
0007-1145
DOI
10.1017/S0007114510000358
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
828928
handle
http://hdl.handle.net/1854/LU-828928
date created
2010-01-15 15:43:21
date last changed
2011-07-07 14:25:01
@article{828928,
  abstract     = {The present study assessed the effect of separate reduction of each enemy-delivering nutrient - protein, fat and carbohydrate - on glucose tolerance and insulin response in a strict carnivore: the domestic cat (Felis cants). Three isoenergetic, home-made diets with the following energetic distribution, low protein (LP): protein 28 \% of metabolisable energy; fat 43 \%; nitrogen-free extract 29\%; low fat: 47, 27 and 25 \%; low carbohydrate (LC): 45, 48 and 7 \%, were tested in a 3 x 3 Latin square design. Nine healthy normal-weight cats were randomly assigned to each of the diets in a random order at intervals of 3 weeks. At the end of each testing period, intravenous glucose tolerance tests were performed. Plasma glucose concentrations and area under the glucose curve showed no differences. Area under the insulin curve was lower when cats were fed the LP diet, and the second insulin peak tended to be delayed when the LC diet was fed. In contrast to other studies, in which energy sources were elevated instead of being reduced, the present trial contradicts the often suggested negative impact of carbohydrates on insulin sensitivity in carnivores, and shows that reducing the dietary carbohydrate content below common amounts for commercial foods evokes an insulin-resistant state, which can be explained by the cats' strict carnivorous nature. It even points to a negative effect of protein on insulin sensitivity, a finding that corresponds with the highly gluconeogenic nature of amino acids in strict carnivores.},
  author       = {Verbrugghe, Adronie and Hesta, Myriam and Van Weyenberg, Stephanie and Papadopoulos, Georgios and Gommeren, Kris and Daminet, Sylvie and Bosmans, Tim and Polis, Ingeborgh and Buyse, Johan and Janssens, Geert},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keyword      = {Carnivores,Carbohydrates,Cats,Energy sources,Insulin resistance,LOW-CARBOHYDRATE DIET,CLINICALLY NORMAL CATS,HIGH-FAT DIET,DIABETES-MELLITUS,REFERENCE VALUES,OVERWEIGHT CATS,NORMAL-WEIGHT,RISK-FACTORS,HIGH-PROTEIN,BODY-WEIGHT},
  language     = {eng},
  number       = {2},
  pages        = {214--221},
  title        = {The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: the domestic cat (Felis catus)},
  url          = {http://dx.doi.org/10.1017/S0007114510000358},
  volume       = {104},
  year         = {2010},
}

Chicago
Verbrugghe, Adronie, Myriam Hesta, Stephanie Van Weyenberg, Georgios Papadopoulos, Kris Gommeren, Sylvie Daminet, Tim Bosmans, Ingeborgh Polis, Johan Buyse, and Geert Janssens. 2010. “The Glucose and Insulin Response to Isoenergetic Reduction of Dietary Energy Sources in a True Carnivore: The Domestic Cat (Felis Catus).” British Journal of Nutrition 104 (2): 214–221.
APA
Verbrugghe, A., Hesta, M., Van Weyenberg, S., Papadopoulos, G., Gommeren, K., Daminet, S., Bosmans, T., et al. (2010). The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: the domestic cat (Felis catus). BRITISH JOURNAL OF NUTRITION, 104(2), 214–221.
Vancouver
1.
Verbrugghe A, Hesta M, Van Weyenberg S, Papadopoulos G, Gommeren K, Daminet S, et al. The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: the domestic cat (Felis catus). BRITISH JOURNAL OF NUTRITION. 2010;104(2):214–21.
MLA
Verbrugghe, Adronie, Myriam Hesta, Stephanie Van Weyenberg, et al. “The Glucose and Insulin Response to Isoenergetic Reduction of Dietary Energy Sources in a True Carnivore: The Domestic Cat (Felis Catus).” BRITISH JOURNAL OF NUTRITION 104.2 (2010): 214–221. Print.