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Florfenicol pharmacokinetics in lactating cows after intravenous, intramuscular and intramammary administration

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Abstract
Pharmacokinetics of florfenicol 30% injectable solution was determined in lactating cows after intravenous, intramammary and intramuscular administration, Serum concentration-time data generated in the present study were analysed by non-compartmental methods based on statistical moment theory. Florfenicol half-life was 176 min, mean residence time 129 min, volume of distribution at steady-state 0.35 L/kg, and total body clearance 2.7 mL/min kg after intravenous administration at 20 mg/kg. The absorption after intramuscular administration appeared slow and the kinetic parameters and the serum concentration vs, time curve were characteristic of absorption rate-dependent elimination, The absorption after intramammary administration of florfenicol at 20 mg/kg was good (53.9%) and resulted in serum concentrations with apparent clinical significance, The intramammary administration resulted in serum florfenicol concentrations that were significantly higher than the respective serum concentrations following intravenous administration 4 h after administration and thereafter. Florfenicol absorption was faster from the mammary gland than from the muscle, The maximum serum concentrations (C-max) were 6.9 mu g/mL at 360 min after intramammary administration and 2.3 mu g/mL at 180 min after intramuscular administration, The bioavailability of florfenicol was 54% and 38% after intramammary and intramuscular administration, respectively, The C-max in milk was 5.4 mu g/mL at 180 min after intravenous and 1.6 mu g/mL at 600 min after intramuscular administration
Keywords
ABSORPTION TIME

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Chicago
Soback, S, Max Paape, R Filep, and KJ Varma. 1995. “Florfenicol Pharmacokinetics in Lactating Cows After Intravenous, Intramuscular and Intramammary Administration.” Journal of Veterinary Pharmacology and Therapeutics 18 (6): 413–417.
APA
Soback, S., Paape, M., Filep, R., & Varma, K. (1995). Florfenicol pharmacokinetics in lactating cows after intravenous, intramuscular and intramammary administration. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 18(6), 413–417.
Vancouver
1.
Soback S, Paape M, Filep R, Varma K. Florfenicol pharmacokinetics in lactating cows after intravenous, intramuscular and intramammary administration. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. 1995;18(6):413–7.
MLA
Soback, S, Max Paape, R Filep, et al. “Florfenicol Pharmacokinetics in Lactating Cows After Intravenous, Intramuscular and Intramammary Administration.” JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 18.6 (1995): 413–417. Print.
@article{820999,
  abstract     = {Pharmacokinetics of florfenicol 30\% injectable solution was determined in lactating cows after intravenous, intramammary and intramuscular administration, Serum concentration-time data generated in the present study were analysed by non-compartmental methods based on statistical moment theory. Florfenicol half-life was 176 min, mean residence time 129 min, volume of distribution at steady-state 0.35 L/kg, and total body clearance 2.7 mL/min kg after intravenous administration at 20 mg/kg. The absorption after intramuscular administration appeared slow and the kinetic parameters and the serum concentration vs, time curve were characteristic of absorption rate-dependent elimination, The absorption after intramammary administration of florfenicol at 20 mg/kg was good (53.9\%) and resulted in serum concentrations with apparent clinical significance, The intramammary administration resulted in serum florfenicol concentrations that were significantly higher than the respective serum concentrations following intravenous administration 4 h after administration and thereafter. Florfenicol absorption was faster from the mammary gland than from the muscle, The maximum serum concentrations (C-max) were 6.9 mu g/mL at 360 min after intramammary administration and 2.3 mu g/mL at 180 min after intramuscular administration, The bioavailability of florfenicol was 54\% and 38\% after intramammary and intramuscular administration, respectively, The C-max in milk was 5.4 mu g/mL at 180 min after intravenous and 1.6 mu g/mL at 600 min after intramuscular administration},
  author       = {Soback, S and Paape, Max and Filep, R and Varma, KJ},
  issn         = {0140-7783},
  journal      = {JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS},
  keyword      = {ABSORPTION TIME},
  language     = {eng},
  number       = {6},
  pages        = {413--417},
  title        = {Florfenicol pharmacokinetics in lactating cows after intravenous, intramuscular and intramammary administration},
  volume       = {18},
  year         = {1995},
}