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Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection

Douglas D Bannerman, Hayley R Springer, Max Paape UGent, Adam CW Kauf and Jesse P Goff (2008) JOURNAL OF DAIRY RESEARCH. 75(3). p.291-301
abstract
Mastitis is one of the most prevalent diseases of cattle. Various studies have reported breed-dependent differences in the risk for developing this disease. Among two major breeds, Jersey cows have been identified as having a lower prevalence of mastitis than Holstein cows. It is well established that the nature of the initial innate immune response to infection influences the ability of the host to clear harmful bacterial pathogens. Whether differences in the innate immune response to intramammary infections explain, in part, the differential prevalence of mastitis in Holstein and Jersey cows remains unknown. The objective of the current study was to evaluate several parameters of the innate immune response of Holstein and Jersey cows to intramammary infection with Staphylococcus aureus, a common mastitis-inducing pathogen. To control for non-breed related factors that could influence these parameters, all cows were of the same parity, in similar stages of milk production, housed and managed under identical conditions, and experimentally infected and sampled in parallel. The following parameters of the innate immune response were evaluated: acute phase protein synthesis of serum amyloid A and lipopolysaccharide-binding protein; total and differential circulating white blood cell counts; milk somatic cell counts; mammary vascular permeability; milk N-acetyl-beta-D-glucosaminidase (NAGase) activity; and production of the cytokines, interferon (IFN)-gamma, interleukin (IL)-12, tumour growth factor(TGF)-alpha, and TGF-beta 1. The temporal response of all of these parameters following infection was similar between Holstein and Jersey cows. Further, with the exception of changes in circulating neutrophils and NAGase activity, the overall magnitude of these parameters were also comparable. Together, these data demonstrate that the innate immune response of Holstein and Jersey cows to Staph. aureus intramammary infection remains highly conserved despite previously reported differences in mastitis prevalence, as well as genotypic and phenotypic traits, that exist between the two breeds.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
mastitis, BETA-D-GLUCOSAMINIDASE, innate immunity, dairy cow, cytokines, breed, GROWTH-FACTOR-ALPHA, TUMOR-NECROSIS-FACTOR, SOMATIC-CELL COUNTS, CLINICAL MASTITIS, DAIRY-COWS, ESCHERICHIA-COLI, TGF-BETA, BOVINE-MILK, SUBCLINICAL MASTITIS
journal title
JOURNAL OF DAIRY RESEARCH
J. Dairy Res.
volume
75
issue
3
pages
291 - 301
Web of Science type
Article
Web of Science id
000258968900006
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
1.437 (2008)
JCR rank
13/45 (2008)
JCR quartile
2 (2008)
ISSN
0022-0299
DOI
10.1017/S0022029908003427
language
English
UGent publication?
no
classification
A1
id
820352
handle
http://hdl.handle.net/1854/LU-820352
date created
2010-01-07 14:21:37
date last changed
2010-01-20 14:25:47
@article{820352,
  abstract     = {Mastitis is one of the most prevalent diseases of cattle. Various studies have reported breed-dependent differences in the risk for developing this disease. Among two major breeds, Jersey cows have been identified as having a lower prevalence of mastitis than Holstein cows. It is well established that the nature of the initial innate immune response to infection influences the ability of the host to clear harmful bacterial pathogens. Whether differences in the innate immune response to intramammary infections explain, in part, the differential prevalence of mastitis in Holstein and Jersey cows remains unknown. The objective of the current study was to evaluate several parameters of the innate immune response of Holstein and Jersey cows to intramammary infection with Staphylococcus aureus, a common mastitis-inducing pathogen. To control for non-breed related factors that could influence these parameters, all cows were of the same parity, in similar stages of milk production, housed and managed under identical conditions, and experimentally infected and sampled in parallel. The following parameters of the innate immune response were evaluated: acute phase protein synthesis of serum amyloid A and lipopolysaccharide-binding protein; total and differential circulating white blood cell counts; milk somatic cell counts; mammary vascular permeability; milk N-acetyl-beta-D-glucosaminidase (NAGase) activity; and production of the cytokines, interferon (IFN)-gamma, interleukin (IL)-12, tumour growth factor(TGF)-alpha, and TGF-beta 1. The temporal response of all of these parameters following infection was similar between Holstein and Jersey cows. Further, with the exception of changes in circulating neutrophils and NAGase activity, the overall magnitude of these parameters were also comparable. Together, these data demonstrate that the innate immune response of Holstein and Jersey cows to Staph. aureus intramammary infection remains highly conserved despite previously reported differences in mastitis prevalence, as well as genotypic and phenotypic traits, that exist between the two breeds.},
  author       = {Bannerman, Douglas D and Springer, Hayley R and Paape, Max and Kauf, Adam CW and Goff, Jesse P},
  issn         = {0022-0299},
  journal      = {JOURNAL OF DAIRY RESEARCH},
  keyword      = {mastitis,BETA-D-GLUCOSAMINIDASE,innate immunity,dairy cow,cytokines,breed,GROWTH-FACTOR-ALPHA,TUMOR-NECROSIS-FACTOR,SOMATIC-CELL COUNTS,CLINICAL MASTITIS,DAIRY-COWS,ESCHERICHIA-COLI,TGF-BETA,BOVINE-MILK,SUBCLINICAL MASTITIS},
  language     = {eng},
  number       = {3},
  pages        = {291--301},
  title        = {Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection},
  url          = {http://dx.doi.org/10.1017/S0022029908003427},
  volume       = {75},
  year         = {2008},
}

Chicago
Bannerman, Douglas D, Hayley R Springer, Max Paape, Adam CW Kauf, and Jesse P Goff. 2008. “Evaluation of Breed-dependent Differences in the Innate Immune Responses of Holstein and Jersey Cows to Staphylococcus Aureus Intramammary Infection.” Journal of Dairy Research 75 (3): 291–301.
APA
Bannerman, D. D., Springer, H. R., Paape, M., Kauf, A. C., & Goff, J. P. (2008). Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection. JOURNAL OF DAIRY RESEARCH, 75(3), 291–301.
Vancouver
1.
Bannerman DD, Springer HR, Paape M, Kauf AC, Goff JP. Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection. JOURNAL OF DAIRY RESEARCH. 2008;75(3):291–301.
MLA
Bannerman, Douglas D, Hayley R Springer, Max Paape, et al. “Evaluation of Breed-dependent Differences in the Innate Immune Responses of Holstein and Jersey Cows to Staphylococcus Aureus Intramammary Infection.” JOURNAL OF DAIRY RESEARCH 75.3 (2008): 291–301. Print.