Advanced search
1 file | 776.44 KB

Sequence learning in Parkinson's disease : focusing on action dynamics and the role of dopaminergic medication

(2016) NEUROPSYCHOLOGIA . 93. p.30-39
Author
Organization
Abstract
Previous studies on movement sequence learning in Parkinson's disease (PD) have produced mixed results. A possible explanation for the inconsistent findings is that some studies have taken dopaminergic medication into account while others have not. Additionally, in previous studies the response modalities did not allow for an investigation of the action dynamics of sequential movements as they unfold over time. In the current study we investigated sequence learning in PD by specifically considering the role of medication status in a sequence learning task where mouse movements were performed. The focus on mouse movements allowed us to examine the action dynamics of sequential movement in terms of initiation time, movement time, movement accuracy, and velocity. PD patients performed the sequence learning task once on their regular medication, and once after overnight withdrawal from their medication. Results showed that sequence learning as reflected in initiation times was impaired when PD patients performed the task ON medication compared to OFF medication. In contrast, sequence learning as reflected in the accuracy of movement trajectories was enhanced when performing the task ON compared to OFF medication. Our findings suggest that while medication enhances execution processes of movement sequence learning, it may at the same time impair planning processes that precede actual execution. Overall, the current study extends earlier findings on movement sequence learning in PD by differentiating between various components of performance, and further refines previous dopamine overdose effects in sequence learning.
Keywords
Motor control, sequence learning, Parkinson

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 776.44 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Ruitenberg, Marit, Wout Duthoo, Patrick Santens, Rachael Seidler, Wim Notebaert, and Elger Abrahamse. 2016. “Sequence Learning in Parkinson’s Disease : Focusing on Action Dynamics and the Role of Dopaminergic Medication.” Neuropsychologia  93: 30–39.
APA
Ruitenberg, Marit, Duthoo, W., Santens, P., Seidler, R., Notebaert, W., & Abrahamse, E. (2016). Sequence learning in Parkinson’s disease : focusing on action dynamics and the role of dopaminergic medication. NEUROPSYCHOLOGIA  , 93, 30–39.
Vancouver
1.
Ruitenberg M, Duthoo W, Santens P, Seidler R, Notebaert W, Abrahamse E. Sequence learning in Parkinson’s disease : focusing on action dynamics and the role of dopaminergic medication. NEUROPSYCHOLOGIA  . 2016;93:30–9.
MLA
Ruitenberg, Marit, Wout Duthoo, Patrick Santens, et al. “Sequence Learning in Parkinson’s Disease : Focusing on Action Dynamics and the Role of Dopaminergic Medication.” NEUROPSYCHOLOGIA  93 (2016): 30–39. Print.
@article{8201673,
  abstract     = {Previous studies on movement sequence learning in Parkinson's disease (PD) have produced mixed results. A possible explanation for the inconsistent findings is that some studies have taken dopaminergic medication into account while others have not. Additionally, in previous studies the response modalities did not allow for an investigation of the action dynamics of sequential movements as they unfold over time. In the current study we investigated sequence learning in PD by specifically considering the role of medication status in a sequence learning task where mouse movements were performed. The focus on mouse movements allowed us to examine the action dynamics of sequential movement in terms of initiation time, movement time, movement accuracy, and velocity. PD patients performed the sequence learning task once on their regular medication, and once after overnight withdrawal from their medication. Results showed that sequence learning as reflected in initiation times was impaired when PD patients performed the task ON medication compared to OFF medication. In contrast, sequence learning as reflected in the accuracy of movement trajectories was enhanced when performing the task ON compared to OFF medication. Our findings suggest that while medication enhances execution processes of movement sequence learning, it may at the same time impair planning processes that precede actual execution. Overall, the current study extends earlier findings on movement sequence learning in PD by differentiating between various components of performance, and further refines previous dopamine overdose effects in sequence learning.},
  author       = {Ruitenberg, Marit and Duthoo, Wout  and Santens, Patrick and Seidler, Rachael and Notebaert, Wim and Abrahamse, Elger},
  issn         = {0028-3932 },
  journal      = {NEUROPSYCHOLOGIA                                                },
  language     = {eng},
  pages        = {30--39},
  title        = {Sequence learning in Parkinson's disease : focusing on action dynamics and the role of dopaminergic medication},
  url          = {http://dx.doi.org/10.1016/j.neuropsychologia.2016.09.027},
  volume       = {93},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: