Advanced search
1 file | 3.53 MB

Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier

(2016) BIOMATERIALS SCIENCE. 4(9). p.1318-1327
Author
Organization
Abstract
Functionalised nanomaterials are gaining popularity for use as drug delivery vehicles and, in particular, mucus penetrating nanoparticles may improve drug bioavailability via the oral route. To date, few polymers have been investigated for their muco-penetration, and the effects of systematic structural changes to polymer architectures on the penetration and diffusion of functionalised nanomaterials through mucosal tissue have not been reported. We investigated the influence of poly(2-oxazoline) alkyl side chain length on nanoparticle diffusion; poly(2-methyl-2-oxazoline), poly(2-ethyl-2-oxazoline), and poly (2-n-propyl-2-oxazoline) were grafted onto the surface of thiolated silica nanoparticles and characterised by FT-IR, Raman and NMR spectroscopy, thermogravimetric analysis, and small angle neutron scattering. Diffusion coefficients were determined in water and in a mucin dispersion (using Nanoparticle Tracking Analysis), and penetration through a mucosal barrier was assessed using an ex vivo fluorescence technique. The addition of a single methylene group in the side chain significantly altered the penetration and diffusion of the materials in both mucin dispersions and mucosal tissue. Nanoparticles functionalised with poly(2-methyl-2-oxazoline) were significantly more diffusive than particles with poly(2-ethyl-2-oxazoline) while particles with poly(2-n-propyl-2-oxazoline) showed no significant increase compared to the unfunctionalised particles. These data show that variations in the polymer structure can radically alter their diffusive properties with clear implications for the future design of mucus penetrating systems.
Keywords
DRUG-DELIVERY, POLY(2-OXAZOLINE)S, HUMAN CERVICOVAGINAL MUCUS, MUCUS-PENETRATING NANOPARTICLES, MUCOADHESION, ORGANOSILICA NANOPARTICLES, AQUEOUS-SOLUTIONS, SURFACE, CHEMISTRY, ACID)

Downloads

  • Biomater-Sci 2016 4 1318-1327.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 3.53 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Mansfield, Edward DH, Victor Retamero De La Rosa, Radoslaw M Kowalczyk, Isabelle Grillo, Richard Hoogenboom, Katy Sillence, Patrick Hole, Adrian C Williams, and Vitaliy V Khutoryanskiy. 2016. “Side Chain Variations Radically Alter the Diffusion of Poly(2-alkyl-2-oxazoline) Functionalised Nanoparticles Through a Mucosal Barrier.” Biomaterials Science 4 (9): 1318–1327.
APA
Mansfield, E. D., Retamero De La Rosa, V., Kowalczyk, R. M., Grillo, I., Hoogenboom, R., Sillence, K., Hole, P., et al. (2016). Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier. BIOMATERIALS SCIENCE, 4(9), 1318–1327.
Vancouver
1.
Mansfield ED, Retamero De La Rosa V, Kowalczyk RM, Grillo I, Hoogenboom R, Sillence K, et al. Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier. BIOMATERIALS SCIENCE. 2016;4(9):1318–27.
MLA
Mansfield, Edward DH, Victor Retamero De La Rosa, Radoslaw M Kowalczyk, et al. “Side Chain Variations Radically Alter the Diffusion of Poly(2-alkyl-2-oxazoline) Functionalised Nanoparticles Through a Mucosal Barrier.” BIOMATERIALS SCIENCE 4.9 (2016): 1318–1327. Print.
@article{8201412,
  abstract     = {Functionalised nanomaterials are gaining popularity for use as drug delivery vehicles and, in particular, mucus penetrating nanoparticles may improve drug bioavailability via the oral route. To date, few polymers have been investigated for their muco-penetration, and the effects of systematic structural changes to polymer architectures on the penetration and diffusion of functionalised nanomaterials through mucosal tissue have not been reported. We investigated the influence of poly(2-oxazoline) alkyl side chain length on nanoparticle diffusion; poly(2-methyl-2-oxazoline), poly(2-ethyl-2-oxazoline), and poly (2-n-propyl-2-oxazoline) were grafted onto the surface of thiolated silica nanoparticles and characterised by FT-IR, Raman and NMR spectroscopy, thermogravimetric analysis, and small angle neutron scattering. Diffusion coefficients were determined in water and in a mucin dispersion (using Nanoparticle Tracking Analysis), and penetration through a mucosal barrier was assessed using an ex vivo fluorescence technique. The addition of a single methylene group in the side chain significantly altered the penetration and diffusion of the materials in both mucin dispersions and mucosal tissue. Nanoparticles functionalised with poly(2-methyl-2-oxazoline) were significantly more diffusive than particles with poly(2-ethyl-2-oxazoline) while particles with poly(2-n-propyl-2-oxazoline) showed no significant increase compared to the unfunctionalised particles. These data show that variations in the polymer structure can radically alter their diffusive properties with clear implications for the future design of mucus penetrating systems.},
  author       = {Mansfield, Edward DH and Retamero De La Rosa, Victor and Kowalczyk, Radoslaw M and Grillo, Isabelle and Hoogenboom, Richard and Sillence, Katy and Hole, Patrick and Williams, Adrian C and Khutoryanskiy, Vitaliy V},
  issn         = {2047-4830},
  journal      = {BIOMATERIALS SCIENCE},
  keyword      = {DRUG-DELIVERY,POLY(2-OXAZOLINE)S,HUMAN CERVICOVAGINAL MUCUS,MUCUS-PENETRATING NANOPARTICLES,MUCOADHESION,ORGANOSILICA NANOPARTICLES,AQUEOUS-SOLUTIONS,SURFACE,CHEMISTRY,ACID)},
  language     = {eng},
  number       = {9},
  pages        = {1318--1327},
  title        = {Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier},
  url          = {http://dx.doi.org/10.1039/c6bm00375c},
  volume       = {4},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: