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Association analyses of candidate single nucleotide polymorphisms on reproductive traits in swine

(2010) JOURNAL OF ANIMAL SCIENCE. 88(1). p.1-15
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Abstract
The ability to identify young females with superior reproduction would have a large economic impact on commercial swine production. Previous studies have discovered SNP associated with economically important traits such as litter size, growth rate, and feed intake. The objective of this study was to test for association of candidate SNP with sow prolificacy reproductive traits in gilts of a Landrace-Duroc-Yorkshire composite population. Association analyses regressed additive ( A), dominant ( D), and imprinting ( I) SNP effects on each trait with an animal model. A carnitine palmitoyltransferase 1A SNP and a glycogen synthase 1 SNP were associated with age at puberty (AP; D = 10 d; P = 0.0037 and A = 3.8 d; P = 0.0078, respectively). Four IGF2 SNP were associated with AP as well, having additive or dominant effects (3.2 to 5.8 d; P <= 0.0052). Two mannosidase 2B2 SNP and 2 prolactin receptor (PRLR) SNP were also associated with AP. Solute carrier 22, subfamily member 5 SNP was weakly associated with AP (D = 3.9 d; P < 0.10). Polymorphisms within glycogen synthase 1 and protein kinase AMP-activated, gamma 3 noncatalytic subunit had associations with ovulation rate. Estrogen receptor (ESR) 1, ESR2, PPAR gamma coactivator 1, and IGFBP3 SNP were significantly associated with weaning-to-estrus interval. Two PRLR SNP were associated with total number of piglets born ( A = 0.57 piglets; P = 0.0095 and D = 0.61 piglets; P = 0.0016, respectively). A SNP within PRLR was also associated with number of piglets born alive ( D = 0.61; P = 0.0016). The PPAR. coactivator 1 SNP was associated with total number of piglets born (D = 0.38 piglets; P = 0.0391) and number of piglets born alive (D = 0.53 piglets; P = 0.0032). The SNP within ESR1 ( A = 0.65 piglets; P = 0.0950), ESR2 ( A = -0.33 piglets; P = 0.0176), IGF2 SNP ( A = -0.26 piglets; P = 0.0032), and IGFBP3 SNP ( D = 0.35 piglets; P = 0.0683) were associated with number of piglets born dead. A leptin SNP was associated with mummified fetuses ( D = 0.09 piglets; P = 0.0978). Many of the SNP analyzed in this study are from genes involved in regulation of metabolism, suggesting that there is an important link between physiological events associated with reproduction and energy utilization. Furthermore, these production and growth trait SNP may serve to assist in selection of young females for superior reproductive performance.
Keywords
INTRAMUSCULAR FAT, single nucleotide polymorphism, ADAPTIVE THERMOGENESIS, PORCINE CHROMOSOME-6, reproductive trait, pig, sow longevity, swine, PIG SKELETAL-MUSCLE, LARGE WHITE-PIGS, LITTER SIZE, OVULATION RATE, BACKFAT THICKNESS, PRIMIPAROUS SOWS, GLYCOGEN-CONTENT

Citation

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MLA
Rempel, LA, DJ Nonneman, TH Wise, et al. “Association Analyses of Candidate Single Nucleotide Polymorphisms on Reproductive Traits in Swine.” JOURNAL OF ANIMAL SCIENCE 88.1 (2010): 1–15. Print.
APA
Rempel, L., Nonneman, D., Wise, T., Erkens, T., Peelman, L., & Rohrer, G. A. (2010). Association analyses of candidate single nucleotide polymorphisms on reproductive traits in swine. JOURNAL OF ANIMAL SCIENCE, 88(1), 1–15.
Chicago author-date
Rempel, LA, DJ Nonneman, TH Wise, Tim Erkens, Luc Peelman, and Gary A Rohrer. 2010. “Association Analyses of Candidate Single Nucleotide Polymorphisms on Reproductive Traits in Swine.” Journal of Animal Science 88 (1): 1–15.
Chicago author-date (all authors)
Rempel, LA, DJ Nonneman, TH Wise, Tim Erkens, Luc Peelman, and Gary A Rohrer. 2010. “Association Analyses of Candidate Single Nucleotide Polymorphisms on Reproductive Traits in Swine.” Journal of Animal Science 88 (1): 1–15.
Vancouver
1.
Rempel L, Nonneman D, Wise T, Erkens T, Peelman L, Rohrer GA. Association analyses of candidate single nucleotide polymorphisms on reproductive traits in swine. JOURNAL OF ANIMAL SCIENCE. 2010;88(1):1–15.
IEEE
[1]
L. Rempel, D. Nonneman, T. Wise, T. Erkens, L. Peelman, and G. A. Rohrer, “Association analyses of candidate single nucleotide polymorphisms on reproductive traits in swine,” JOURNAL OF ANIMAL SCIENCE, vol. 88, no. 1, pp. 1–15, 2010.
@article{818023,
  abstract     = {The ability to identify young females with superior reproduction would have a large economic impact on commercial swine production. Previous studies have discovered SNP associated with economically important traits such as litter size, growth rate, and feed intake. The objective of this study was to test for association of candidate SNP with sow prolificacy reproductive traits in gilts of a Landrace-Duroc-Yorkshire composite population. Association analyses regressed additive ( A), dominant ( D), and imprinting ( I) SNP effects on each trait with an animal model. A carnitine palmitoyltransferase 1A SNP and a glycogen synthase 1 SNP were associated with age at puberty (AP; D = 10 d; P = 0.0037 and A = 3.8 d; P = 0.0078, respectively). Four IGF2 SNP were associated with AP as well, having additive or dominant effects (3.2 to 5.8 d; P <= 0.0052). Two mannosidase 2B2 SNP and 2 prolactin receptor (PRLR) SNP were also associated with AP. Solute carrier 22, subfamily member 5 SNP was weakly associated with AP (D = 3.9 d; P < 0.10). Polymorphisms within glycogen synthase 1 and protein kinase AMP-activated, gamma 3 noncatalytic subunit had associations with ovulation rate. Estrogen receptor (ESR) 1, ESR2, PPAR gamma coactivator 1, and IGFBP3 SNP were significantly associated with weaning-to-estrus interval. Two PRLR SNP were associated with total number of piglets born ( A = 0.57 piglets; P = 0.0095 and D = 0.61 piglets; P = 0.0016, respectively). A SNP within PRLR was also associated with number of piglets born alive ( D = 0.61; P = 0.0016). The PPAR. coactivator 1 SNP was associated with total number of piglets born (D = 0.38 piglets; P = 0.0391) and number of piglets born alive (D = 0.53 piglets; P = 0.0032). The SNP within ESR1 ( A = 0.65 piglets; P = 0.0950), ESR2 ( A = -0.33 piglets; P = 0.0176), IGF2 SNP ( A = -0.26 piglets; P = 0.0032), and IGFBP3 SNP ( D = 0.35 piglets; P = 0.0683) were associated with number of piglets born dead. A leptin SNP was associated with mummified fetuses ( D = 0.09 piglets; P = 0.0978). Many of the SNP analyzed in this study are from genes involved in regulation of metabolism, suggesting that there is an important link between physiological events associated with reproduction and energy utilization. Furthermore, these production and growth trait SNP may serve to assist in selection of young females for superior reproductive performance.},
  author       = {Rempel, LA and Nonneman, DJ and Wise, TH and Erkens, Tim and Peelman, Luc and Rohrer, Gary A},
  issn         = {0021-8812},
  journal      = {JOURNAL OF ANIMAL SCIENCE},
  keywords     = {INTRAMUSCULAR FAT,single nucleotide polymorphism,ADAPTIVE THERMOGENESIS,PORCINE CHROMOSOME-6,reproductive trait,pig,sow longevity,swine,PIG SKELETAL-MUSCLE,LARGE WHITE-PIGS,LITTER SIZE,OVULATION RATE,BACKFAT THICKNESS,PRIMIPAROUS SOWS,GLYCOGEN-CONTENT},
  language     = {eng},
  number       = {1},
  pages        = {1--15},
  title        = {Association analyses of candidate single nucleotide polymorphisms on reproductive traits in swine},
  url          = {http://dx.doi.org/10.2527/jas.2009-1985},
  volume       = {88},
  year         = {2010},
}

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