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Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; project no: 261357; 2010-2015

(2016) ALLERGY. 71(11). p.1513-1525
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Abstract
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
Keywords
polysensitization, rhinitis, multimorbidity, IgE, asthma, CHRONIC RESPIRATORY-DISEASES, EUROPEAN INNOVATION PARTNERSHIP, BIRTH COHORT, CHILDHOOD ASTHMA, ATOPIC-DERMATITIS, IMMUNOLOGICAL REACTIVITY, IGE SENSITIZATION, IMMUNE-RESPONSES, IMMUNOGLOBULIN-E, INTEGRATED CARE

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Citation

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Chicago
Bousquet, J, JM Anto, M Akdis, C Auffray, T Keil, I Momas, DS Postma, et al. 2016. “Paving the Way of Systems Biology and Precision Medicine in Allergic Diseases: The MeDALL Success Story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015.” Allergy 71 (11): 1513–1525.
APA
Bousquet, J, Anto, J., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D., et al. (2016). Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; project no: 261357; 2010-2015. ALLERGY, 71(11), 1513–1525.
Vancouver
1.
Bousquet J, Anto J, Akdis M, Auffray C, Keil T, Momas I, et al. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; project no: 261357; 2010-2015. ALLERGY. 2016;71(11):1513–25.
MLA
Bousquet, J, JM Anto, M Akdis, et al. “Paving the Way of Systems Biology and Precision Medicine in Allergic Diseases: The MeDALL Success Story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015.” ALLERGY 71.11 (2016): 1513–1525. Print.
@article{8173350,
  abstract     = {MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.},
  author       = {Bousquet, J and Anto, JM and Akdis, M and Auffray, C and Keil, T and Momas, I and Postma, DS and Valenta, R and Wickman, M and Cambon-Thomsen, A and Haahtela, T and Lambrecht, Bart and Carlsen, KCL and Koppelman, GH and Sunyer, J and Zuberbier, T and Annesi-Maesano, I and Arno, A and Bindslev-Jensen, C and De Carlo, G and Forastiere, F and Heinrich, J and Kowalski, ML and Maier, D and Melen, E and Palkonen, S and Smit, HA and Standl, M and Wright, J and Asarnoj, A and Benet, M and Ballardini, N and Garcia-Aymerich, J and Gehring, U and Guerra, S and Hohman, C and Kull, I and Lupinek, C and Pinart, M and Skrindo, I and Westman, M and Smagghe, D and Akdis, C and Albang, R and Anastasova, V and Anderson, N and Bachert, Claus and Ballereau, S and Ballester, F and Basagana, X and Bedbrook, A and Bergstrom, A and von Berg, A and Brunekreef, B and Burte, E and Carlsen, KH and Chatzi, L and Coquet, Jonathan and Curin, M and Demoly, P and Eller, E and Fantini, MP and Gerhard, B and Hammad, Hamida and von Hertzen, L and Hovland, V and Jacquemin, B and Just, J and Keller, T and Kerkhof, M and Kiss, R and Kogevinas, M and Koletzko, S and Lau, S and Lehmann, I and Lemonnier, N and McEachan, R and Makela, M and Mestres, J and Minina, E and Mowinckel, P and Nadif, R and Nawijn, M and Oddie, S and Pellet, J and Pin, I and Porta, D and Ranciere, F and Rial-Sebbag, A and Saeys, Yvan and Schuijs, Martijn and Siroux, V and Tischer, CG and Torrent, M and Varraso, R and De Vocht, J and Wenger, K and Wieser, S and Xu, C},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {polysensitization,rhinitis,multimorbidity,IgE,asthma,CHRONIC RESPIRATORY-DISEASES,EUROPEAN INNOVATION PARTNERSHIP,BIRTH COHORT,CHILDHOOD ASTHMA,ATOPIC-DERMATITIS,IMMUNOLOGICAL REACTIVITY,IGE SENSITIZATION,IMMUNE-RESPONSES,IMMUNOGLOBULIN-E,INTEGRATED CARE},
  language     = {eng},
  number       = {11},
  pages        = {1513--1525},
  title        = {Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; project no: 261357; 2010-2015},
  url          = {http://dx.doi.org/10.1111/all.12880},
  volume       = {71},
  year         = {2016},
}

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