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Inflammasomes: caspase-1-activating platforms with critical roles in host defense

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Abstract
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections. Inflammasome activation induces inflammation through secretion of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18 and through extracellular release of the alarmin high mobility group box 1. Moreover, caspase-1 activation by inflammasomes counters bacterial replication and induces pyroptosis, a specialized cell death program that removes infected immune cells as part of the host defense system. It is thus not surprising that bacterial and viral pathogens evolved virulence factors targeting inflammasome activation and activity. Here, we provide an overview of the distinct inflammasome complexes that are activated in a pathogen-specific manner and discuss the diverse strategies employed by viruses and bacteria to modulate inflammasome function.
Keywords
NOD-like receptors, inflammasome, pathogen, interleukin, pyroptosis, infection, caspase-1

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Citation

Please use this url to cite or link to this publication:

Chicago
Vande Walle, Lieselotte, and Mohamed Lamkanfi. 2011. “Inflammasomes: Caspase-1-activating Platforms with Critical Roles in Host Defense.” Frontiers in Microbiology 2.
APA
Vande Walle, L., & Lamkanfi, M. (2011). Inflammasomes: caspase-1-activating platforms with critical roles in host defense. FRONTIERS IN MICROBIOLOGY, 2.
Vancouver
1.
Vande Walle L, Lamkanfi M. Inflammasomes: caspase-1-activating platforms with critical roles in host defense. FRONTIERS IN MICROBIOLOGY. 2011;2.
MLA
Vande Walle, Lieselotte, and Mohamed Lamkanfi. “Inflammasomes: Caspase-1-activating Platforms with Critical Roles in Host Defense.” FRONTIERS IN MICROBIOLOGY 2 (2011): n. pag. Print.
@article{8173111,
  abstract     = {Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections. Inflammasome activation induces inflammation through secretion of the pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18 and through extracellular release of the alarmin high mobility group box 1. Moreover, caspase-1 activation by inflammasomes counters bacterial replication and induces pyroptosis, a specialized cell death program that removes infected immune cells as part of the host defense system. It is thus not surprising that bacterial and viral pathogens evolved virulence factors targeting inflammasome activation and activity. Here, we provide an overview of the distinct inflammasome complexes that are activated in a pathogen-specific manner and discuss the diverse strategies employed by viruses and bacteria to modulate inflammasome function.},
  articleno    = {3},
  author       = {Vande Walle, Lieselotte and Lamkanfi, Mohamed},
  issn         = {1664-302X},
  journal      = {FRONTIERS IN MICROBIOLOGY},
  keyword      = {NOD-like receptors,inflammasome,pathogen,interleukin,pyroptosis,infection,caspase-1},
  language     = {eng},
  pages        = {6},
  title        = {Inflammasomes: caspase-1-activating platforms with critical roles in host defense},
  url          = {http://dx.doi.org/10.3389/fmicb.2011.00003},
  volume       = {2},
  year         = {2011},
}

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