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Highly active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) in the cross-coupling of Grignard reagents with aryl chlorides

(2009) ORGANOMETALLICS. 28(9). p.2915-2919
Author
Organization
Abstract
Cross-coupling reactions of Grignard reagents with functionalized aryl, heteroaryl, and sterically hindered aryl chlorides are reported. A protocol disclosing the coupling of a wide range of substrates using complexes of the type [Pd(mu-Cl)(Cl)(NHC)](2) (NHC = N-heterocyclic carbene) as precatalysts (at low catalyst loading) under mild conditions is presented. The system allows for the synthesis of highly sterically hindered products, including tri- and tetra-ortho-substituted biaryls.
Keywords
RESTRICTED FLEXIBILITY, PALLADIUM CATALYSTS, KUMADA REACTION, BR/MG EXCHANGE, BOND FORMATION, C-C, LIGANDS, COMPLEXES, ALCOHOLS, BROMIDES

Citation

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MLA
Hartmann, Caroline E, Steven Nolan, and Catherine Cazin. “Highly Active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic Carbene) in the Cross-coupling of Grignard Reagents with Aryl Chlorides.” ORGANOMETALLICS 28.9 (2009): 2915–2919. Print.
APA
Hartmann, C. E., Nolan, S., & Cazin, C. (2009). Highly active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) in the cross-coupling of Grignard reagents with aryl chlorides. ORGANOMETALLICS, 28(9), 2915–2919.
Chicago author-date
Hartmann, Caroline E, Steven Nolan, and Catherine Cazin. 2009. “Highly Active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic Carbene) in the Cross-coupling of Grignard Reagents with Aryl Chlorides.” Organometallics 28 (9): 2915–2919.
Chicago author-date (all authors)
Hartmann, Caroline E, Steven Nolan, and Catherine Cazin. 2009. “Highly Active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic Carbene) in the Cross-coupling of Grignard Reagents with Aryl Chlorides.” Organometallics 28 (9): 2915–2919.
Vancouver
1.
Hartmann CE, Nolan S, Cazin C. Highly active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) in the cross-coupling of Grignard reagents with aryl chlorides. ORGANOMETALLICS. 2009;28(9):2915–9.
IEEE
[1]
C. E. Hartmann, S. Nolan, and C. Cazin, “Highly active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) in the cross-coupling of Grignard reagents with aryl chlorides,” ORGANOMETALLICS, vol. 28, no. 9, pp. 2915–2919, 2009.
@article{8169427,
  abstract     = {Cross-coupling reactions of Grignard reagents with functionalized aryl, heteroaryl, and sterically hindered aryl chlorides are reported. A protocol disclosing the coupling of a wide range of substrates using complexes of the type [Pd(mu-Cl)(Cl)(NHC)](2) (NHC = N-heterocyclic carbene) as precatalysts (at low catalyst loading) under mild conditions is presented. The system allows for the synthesis of highly sterically hindered products, including tri- and tetra-ortho-substituted biaryls.},
  author       = {Hartmann, Caroline E and Nolan, Steven and Cazin, Catherine},
  issn         = {0276-7333},
  journal      = {ORGANOMETALLICS},
  keywords     = {RESTRICTED FLEXIBILITY,PALLADIUM CATALYSTS,KUMADA REACTION,BR/MG EXCHANGE,BOND FORMATION,C-C,LIGANDS,COMPLEXES,ALCOHOLS,BROMIDES},
  language     = {eng},
  number       = {9},
  pages        = {2915--2919},
  title        = {Highly active [Pd(µ-Cl)(Cl)(NHC)]2 (NHC = N-heterocyclic carbene) in the cross-coupling of Grignard reagents with aryl chlorides},
  url          = {http://dx.doi.org/10.1021/om900072f},
  volume       = {28},
  year         = {2009},
}

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