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Highly active well-defined palladium precatalysts for the efficient amination of aryl chlorides

(2011) ORGANOMETALLICS. 30(16). p.4432-4436
Author
Organization
Abstract
The efficient preparation of [Pd(Amphos)(cinnamyl)Cl)] and [Pd(Amphos)(TFA)(kappa(2)-N,C-C6H4-CH2-NMe2)] (Amphos = 4-(di-tert-butylphosphino)-N,N-dimethylaniline and TFA = trifluoroacetate), two new well-defined palladium precatalysts, is reported. These complexes prove highly active in the Buchwald-Hartwig amination reaction, allowing the coupling of a wide range of (hetero)aryl chlorides, including unactivated, neutral, and sterically hindered substrates, with a wide range of amines, including primary and secondary amines. Finally, the catalytic systems have proven efficient at low catalyst loadings ranging from 0.1 to 0.3 mol %.
Keywords
N-HETEROCYCLIC CARBENE, CROSS-COUPLING REACTIONS, TEMPERATURE SUZUKI-MIYAURA, LONG-LIVED CATALYSTS, BUCHWALD-HARTWIG, (NHC)PD(ALLYL)CL NHC, BOND FORMATION, RECYCLABLE CATALYSTS, ARYLBORONIC ACIDS, C-N

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Chicago
Chartoire, Anthony, Mathieu Lesieur, Alexandra MZ Slawin, Steven Nolan, and Catherine Cazin. 2011. “Highly Active Well-defined Palladium Precatalysts for the Efficient Amination of Aryl Chlorides.” Organometallics 30 (16): 4432–4436.
APA
Chartoire, A., Lesieur, M., Slawin, A. M., Nolan, S., & Cazin, C. (2011). Highly active well-defined palladium precatalysts for the efficient amination of aryl chlorides. ORGANOMETALLICS, 30(16), 4432–4436.
Vancouver
1.
Chartoire A, Lesieur M, Slawin AM, Nolan S, Cazin C. Highly active well-defined palladium precatalysts for the efficient amination of aryl chlorides. ORGANOMETALLICS. 2011;30(16):4432–6.
MLA
Chartoire, Anthony et al. “Highly Active Well-defined Palladium Precatalysts for the Efficient Amination of Aryl Chlorides.” ORGANOMETALLICS 30.16 (2011): 4432–4436. Print.
@article{8169015,
  abstract     = {The efficient preparation of [Pd(Amphos)(cinnamyl)Cl)] and [Pd(Amphos)(TFA)(kappa(2)-N,C-C6H4-CH2-NMe2)] (Amphos = 4-(di-tert-butylphosphino)-N,N-dimethylaniline and TFA = trifluoroacetate), two new well-defined palladium precatalysts, is reported. These complexes prove highly active in the Buchwald-Hartwig amination reaction, allowing the coupling of a wide range of (hetero)aryl chlorides, including unactivated, neutral, and sterically hindered substrates, with a wide range of amines, including primary and secondary amines. Finally, the catalytic systems have proven efficient at low catalyst loadings ranging from 0.1 to 0.3 mol %.},
  author       = {Chartoire, Anthony and Lesieur, Mathieu and Slawin, Alexandra MZ and Nolan, Steven and Cazin, Catherine},
  issn         = {0276-7333},
  journal      = {ORGANOMETALLICS},
  keywords     = {N-HETEROCYCLIC CARBENE,CROSS-COUPLING REACTIONS,TEMPERATURE SUZUKI-MIYAURA,LONG-LIVED CATALYSTS,BUCHWALD-HARTWIG,(NHC)PD(ALLYL)CL NHC,BOND FORMATION,RECYCLABLE CATALYSTS,ARYLBORONIC ACIDS,C-N},
  language     = {eng},
  number       = {16},
  pages        = {4432--4436},
  title        = {Highly active well-defined palladium precatalysts for the efficient amination of aryl chlorides},
  url          = {http://dx.doi.org/10.1021/om2005222},
  volume       = {30},
  year         = {2011},
}

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